Abstract: An array substrate, a display panel, and a display device. The array substrate includes a display area, a fan-out area, a bonding area, the fan-out area and the bonding area being arranged at a side of the display area along a first direction, the bonding area being arranged at a side of the fan-out area away from the display area, a substrate, a plurality of signal leads arranged on the substrate and located in the bonding area, and a plurality of pads configured to be electrically connected to a driver integrated circuit. The plurality of pads are stacked on the plurality of signal leads in a one-to-one correspondence and are electrically connected to the plurality of signal leads correspondingly.

Abstract: A display panel includes a substrate; multiple first electrode signal lines formed on the substrate; and multiple isolation columns located on a side of the multiple first electrode signal lines facing away from the substrate. The display panel includes multiple pixel regions and multiple partition regions, each of the multiple pixel regions is internally provided with a respective one of the multiple isolation columns, each of the multiple isolation columns is internally provided with multiple pixel openings, and each of the multiple pixel openings is internally provided with a first electrode and a light-emitting function layer located on a side of the first electrode facing away from the substrate, the first electrode is electrically connected to a corresponding one of the multiple first electrode signal lines, and the multiple partition regions are used for partitioning a second electrode between two adjacent pixel regions.

Abstract: A touch panel, a display panel, and a display device. The touch panel includes: a substrate; an electrode layer disposed on the substrate. The electrode layer includes a plurality of second electrodes and a plurality of first electrodes arranged to intersect with the second electrodes; and an insulating layer. The second electrodes and the first electrodes are insulated by the insulating layer, and the insulating layer includes an inorganic material layer and an organic material layer. The inorganic material layer is provided with openings at least corresponding to intersections of the second electrodes and the first electrodes, and a part of the organic material layer fills in the openings.

Abstract: A touch panel, a display panel, and a display device. The touch panel includes: a substrate; an electrode layer disposed on the substrate. The electrode layer includes a plurality of second electrodes and a plurality of first electrodes arranged to intersect with the second electrodes; and an insulating layer. The second electrodes and the first electrodes are insulated by the insulating layer, and the insulating layer includes an inorganic material layer and an organic material layer. The inorganic material layer is provided with openings at least corresponding to intersections of the second electrodes and the first electrodes, and a part of the organic material layer fills in the openings.

Abstract: The invention discloses an OCT probe used for human open lumen system, comprising a probe protector, a probe body, an oily liquid, a metal coil, a probe guard tip and a light-guided optical fiber; the probe body is match mounted will the metal coil, and the metal coil is mounted on the rear end of the probe body; the light-guided optical fiber is fixed inside the probe body; the probe guard tip is sleeved on the probe body, the probe protector is sleeved on the probe guard tip and sleeved on the metal coil; the oily liquid is filled between the probe guard tip and the probe protector, and between the metal coil and the probe protector. The invention effectively remedy for the defect that the image is unclear by filling the oily liquid between the probe protector and the probe body.

Abstract: A display panel includes a substrate; multiple first electrode signal lines formed on the substrate; and multiple isolation columns located on a side of the multiple first electrode signal lines facing away from the substrate. The display panel includes multiple pixel regions and multiple partition regions, each of the multiple pixel regions is internally provided with a respective one of the multiple isolation columns, each of the multiple isolation columns are internally provided with multiple pixel openings, and each of the multiple pixel openings is internally provided with a first electrode and a light-emitting function layer located on a side of the first electrode facing away from the substrate, the first electrode is electrically connected to a corresponding one of the multiple first electrode signal lines, and the multiple partition regions are used for partitioning a second electrode between two adjacent pixel regions.

Abstract: Systems and methods for controlling automated systems, such as robots and other devices/resources, using integer programming and column generation techniques, are provided. The system retrieves location and movement data corresponding to at least one automated system, and processes the location and movement data using an integer linear programming algorithm. The system also optimizes the integer linear programming algorithm using a column generation algorithm, and solves a pricing problem associated with generating routes for the at least one automated system. Then, the system generates a route based on outputs of the integer linear programming algorithm, the column generation algorithm, and solving of the pricing problem, and transmits the route to the at least one automated system, the at least one automated system executing the route to control a location or a movement of the at least one automated system.

Abstract: A building earthquake resistance structure includes an integrally connected roof support frame, used for supporting a roof of a building independently from walls of the building; a plurality of support columns, fixedly connected to the roof support frame; an annular trench, arranged in the ground around the building; an annular damping frame, arranged within the annular trench, lower ends of the support columns being fixedly connected to the annular damping frame; a plurality of dampers, arranged between a bottom portion of the annular trench and the annular damping frame. An earthquake resistance method for the building earthquake resistance structure prevents damage caused by the roof collapsing during an earthquake by supporting the roof of the existing building in the ground via the support columns. The building earthquake resistance structure is easy to construct and suitable for transforming traditional old buildings.

Abstract: A building earthquake resistance structure includes an integrally connected roof support frame, used for supporting a roof of a building independently from walls of the building; a plurality of support columns, fixedly connected to the roof support frame; an annular trench, arranged in the ground around the building; an annular damping came, arranged within the annular trench, lower ends of the support columns being fixedly connected to the annular damping frame; a plurality of dampers, arranged between a bottom portion of the annular trench and the annular damping frame. An earthquake resistance method for the building earthquake resistance structure prevents damage caused by the roof collapsing during an earthquake by supporting the roof of the existing building in the ground via the support columns. The building earthquake resistance structure is easy to construct and suitable for transforming traditional old buildings.

Abstract: The present invention provides an OCT catheter for the respiratory tract. An optical fiber connecting part is connected to an optical fiber, a guide wire assembly is sleeved outside the optical fiber connected to an optical fiber interface, an end of the guide wire assembly is sleeved inside the optical fiber interface connected to an optical fiber coupler, the optical fiber coupler is sleeved inside a connector sleeved inside a fixing head, an end of the fixing head is sleeved inside a sealing assembly, and the guide wire assembly sequentially passes through the connector, the fixing head and the sealing assembly. The OCT catheter is connected to the SC-type optical fiber interface through the SC-SC optical fiber coupler of a driving module. By adopting a guide wire with a small diameter, the medical OCT catheter can be applied to higher-generation bronchi, thereby expanding the application range.

Abstract: The present disclosure relates to novel crystalline forms of an androgen receptor antagonist drug (ODM-201 represented by formula (I)), preparation method thereof and use thereof. The crystalline form B or the crystalline form C of ODM-201 provided by the present disclosure has low hygroscopicity, good stability, high solubility, excellent flowability, optimal particle size with uniform distribution, which provides a new choice for the preparation of drugs containing ODM-201 and is of great value for drug development.

Abstract: The present disclosure relates to a novel crystalline form E of Tafamidis meglumine, process for preparation and use thereof. When compared with prior crystalline forms, the novel crystalline form of the present disclosure has the advantages of simple process and low hygroscopicity, which provides a new and better choice for the development of Tafamidis meglumine drug product and is of great significance.

Abstract: The present disclosure relates to crystalline Form 1, Form 2, Form 3 of Ponesimod, a selective S1P1 receptor modulator, and preparation methods thereof. The X-ray powder diffraction pattern of Form 1 shows characteristic peaks at 2theta values of 18.1°±0.2°, 14.6°±0.2°, 11.3°±0.2°; the X-ray powder diffraction pattern of Form 2 shows characteristic peaks at 2theta values of 3.8°±0.2°, 10.8°±0.2°, 6.1°±0.2°; the X-ray powder diffraction pattern of Form 3 shows characteristic peaks at 2theta values of 12.2°±0.2°, 6.2°±0.2°, 5.6°±0.2°. The crystalline forms in present disclosure not only have better stability but also have higher solubility compared with the prior art forms, they are more suitable for the formulation development of Ponesimod.

Abstract: The present disclosure relates to crystalline Form 1, Form 2, Form 3 of Ponesimod, a selective S1P1 receptor modulator, and preparation methods thereof. The X-ray powder diffraction pattern of Form 1 shows characteristic peaks at 2theta values of 18.1°±0.2°, 14.6°±0.2°, 11.3°±0.2°; the X-ray powder diffraction pattern of Form 2 shows characteristic peaks at 2theta values of 3.8°±0.2°, 10.8°±0.2°, 6.1°±0.2°; the X-ray powder diffraction pattern of Form 3 shows characteristic peaks at 2theta values of 12.2°±0.2°, 6.2°±0.2°, 5.6°±0.2°. The crystalline forms in present disclosure not only have better stability but also have higher solubility compared with the prior art forms, they are more suitable for the formulation development of Ponesimod.

Abstract: The invention discloses an OCT probe used for human open lumen system, comprising a probe protector, a probe body, an oily liquid, a metal coil, a probe guard tip and a light-guided optical fiber; the probe body is match mounted will the metal coil, and the metal coil is mounted on the rear end of the probe body; the light-guided optical fiber is fixed inside the probe body; the probe guard tip is sleeved on the probe body, the probe protector is sleeved on the probe guard tip and sleeved on the metal coil; the oily liquid is filled between the probe guard tip and the probe protector, and between the metal coil and the probe protector. The invention effectively remedy for the defect that the image is unclear by filling the oily liquid between the probe protector and the probe body.

Abstract: The present disclosure relates to a novel crystalline form E of Tafamidis meglumine, process for preparation and use thereof. When compared with prior crystalline forms, the novel crystalline form of the present disclosure has the advantages of simple process and low hygroscopicity, which provides a new and better choice for the development of Tafamidis meglumine drug product and is of great significance.

Abstract: The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-car boxylic acid dimethylamide(compound I), its salts, and process for preparation thereof. Crystalline forms in the present invention have good stability, low hygroscopicity, good processability, easy treatability and other favorable properties. In addition, the process is simple, low cost, and has an important value for future optimization and development of the drug.

Abstract: Novel crystalline Forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3?-methyl-T-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.

Abstract: Novel crystalline Forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3?-methyl-T-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.

Abstract: The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-car boxylic acid dimethylamide(compound I), its salts, and process for preparation thereof. Crystalline forms in the present invention have good stability, low hygroscopicity, good processability, easy treatability and other favorable properties. In addition, the process is simple, low cost, and has an important value for future optimization and development of the drug.