Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: A femoral neck measuring method includes: measuring an affected limb after a femoral stem prosthesis is installed through an optical localization probe, and calculating an actual length of the femoral neck needed by the affected limb according to an osteotomy surface of the affected limb determined after the femoral stem prosthesis is installed; determining a femoral ball prosthesis and a femoral neck prosthesis to be selected according to the calculated actual length of the femoral neck and a length of a femoral neck of a healthy limb measured before surgery; and measuring a length of the affected limb after the femoral ball prosthesis and the femoral neck prosthesis are implanted, and restraining a length difference between the healthy limb and the affected limb by adjusting a length of the femoral neck of the affected limb.

Abstract: Embodiments of the disclosure provide a method and apparatus for upgrading a system version of a system. The method can include: acquiring, using circuitry, from a first storage space a current system version identification corresponding to a current system version; acquiring, using circuitry, from a second storage space a backup system version identification corresponding to a backup system version; comparing, using circuitry, the current system version identification with the backup system version identification; and configuring the system based on the comparison.

Abstract: A structure and method for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area, belonging to the field of ecological restoration technologies. The structure for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area provided by the present invention includes an ecological water-harvesting pond, ecological intercepting ditches, an improved soil layer laid on the surface of a to-be-restored slope region and a soil restoration ecological network disposed on the improved soil layer. The improved soil layer, the ecological water-harvesting pond and the ecological intercepting ditches are each provided with a combined plant synusia system.

Abstract: The present invention provides a method for establishing a characteristic atlas of whole immune cells in lungs of mice with acute lung injury, including: extraction of the whole immune cells in lung; labeling of antibody with specific metal isotope for mass cytometry; staining the immune cells with the detection antibody; and mass cytometer analysis. The present invention is capable of isolating whole immune cells with high yield and viability on the basis of ensuring cell purity, greater than that of the conventional grinding method. The present invention binds stable metal isotopes to antibodies, while mass spectrometry flow channels are designed based on the principle of minimal channel interference to achieve a comprehensive description on the classification and function of whole immune cells in lung of the mouse with up to 43 markers simultaneously; dynamic alterations in the whole immune cells in lung of the mouse can also be observed.

Abstract: The present disclosure includes an affective interaction apparatus, comprising an affective interaction computing module including a user intention computing processor to receive emotion-related data and an emotion state of a user; and identify a user intention based on the emotion-related data and the emotion state, the user intention including an affective intention and/or an interaction intention, the affective intention corresponding to the emotion state and including an affective need of the emotion state, the interaction intention including one or more transaction intentions.

Abstract: Direct growth methods for preparing diamond-assisted heat-dissipation silicon carbide substrates of GaN-HEMTs are disclosed. In an embodiment, the direct growth method includes the following steps: (1) etching holes in a surface of a silicon carbide substrate to produce a silicon carbide wafer; (2) ultrasonic cleaning the produced silicon carbide wafer; (3) establishing an auxiliary nucleation point on a surface of the silicon carbide wafer; (4) depositing a diamond layer; (5) removing the portion of the diamond layer on the upper surface while retaining the portion of the diamond layer in the holes; (6) ultrasonic cleaning; and (7) depositing diamond in the holes on the silicon carbide wafer until the holes are fully filled.

Abstract: The present disclosure includes an affective interaction apparatus, comprising an affective interaction computing module including a user intention computing processor to receive emotion-related data and an emotion state of a user; and identify a user intention based on the emotion-related data and the emotion state, the user intention including an affective intention and/or an interaction intention, the affective intention corresponding to the emotion state and including an affective need of the emotion state, the interaction intention including one or more transaction intentions.

Abstract: A structure and method for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area, belonging to the field of ecological restoration technologies. The structure for three-dimensional restoration of slope soil in an abandoned ion-absorbed rare earth mining area provided by the present invention includes an ecological water-harvesting pond, ecological intercepting ditches, an improved soil layer laid on the surface of a to-be-restored slope region and a soil restoration ecological network disposed on the improved soil layer. The improved soil layer, the ecological water-harvesting pond and the ecological intercepting ditches are each provided with a combined plant synusia system.

Abstract: Direct growth methods for preparing diamond-assisted heat-dissipation silicon carbide substrates of GaN-HEMTs are disclosed. In an embodiment, the direct growth method includes the following steps: (1) etching holes in a surface of a silicon carbide substrate to produce a silicon carbide wafer; (2) ultrasonic cleaning the produced silicon carbide wafer; (3) establishing an auxiliary nucleation point on a surface of the silicon carbide wafer; (4) depositing a diamond layer; (5) removing the portion of the diamond layer on the upper surface while retaining the portion of the diamond layer in the holes; (6) ultrasonic cleaning; and (7) depositing diamond in the holes on the silicon carbide wafer until the holes are fully filled.

Abstract: An APB (Advanced Peripheral Bus) bus-based I2C (Inter-Integrated Circuit) communication device is provided. The device comprises: an APB interface module (1), an I2C bus interface module (2), an encryption module (3), a decryption module (4), and a control module (5), wherein the encryption module (3) receives plaintext data and a key from a master via the APB interface module (1), generates, when enabled, ciphertext data according to the plaintext data and the key, and sends the ciphertext data to a slave via the I2C bus interface module (2); the decryption module (4)receives the ciphertext data from the slave via the I2C bus interface module (2) and receives a key from the master via the APB interface module (1), generates, when enabled, plaintext data according to the ciphertext data and the key, and sends the plaintext data to the master via the APB interface module (1). The device can improve the security of data transmission.

Abstract: Embodiments of the disclosure provide a method and apparatus for upgrading a system version of a system. The method can include: acquiring, using circuitry, from a first storage space a current system version identification corresponding to a current system version; acquiring, using circuitry, from a second storage space a backup system version identification corresponding to a backup system version; comparing, using circuitry, the current system version identification with the backup system version identification; and configuring the system based on the comparison.

Abstract: The present invention provides a pixel circuit comprising a pinned photodiode, at least one first transfer gate for electrically connecting the pinned photodiode to at least one storage node and at least one further transfer gate. The at least one further gate can connect the at least one storage node with at least one floating diffusion node. At least one merging switch is included for allowing connection between the at least one floating diffusion node with one or more capacitor nodes, which can accept charge that exceeds the maximum storage capacity of the storage node.

Abstract: The present invention provides a pixel circuit comprising a pinned photodiode, at least one first transfer gate for electrically connecting the pinned photodiode to at least one storage node and at least one further transfer gate. The at least one further gate can connect the at least one storage node with at least one floating diffusion node. At least one merging switch is included for allowing connection between the at least one floating diffusion node with one or more capacitor nodes, which can accept charge that exceeds the maximum storage capacity of the storage node.

Abstract: A communication processing method and apparatus, and a terminal are provided. The method includes: receiving a communication request including a called user identifier and sent by a calling user; searching, according to the called user identifier, for all terminals corresponding to the called user identifier, where the all terminals include a terminal which has logged in by using the called user identifier and does not log in currently; and sending the communication request to all communicable terminals of the all terminals. In the embodiments of the present invention, after receiving a communication request sent by a calling user, an application server can send the communication request to all communicable terminals. Therefore, a terminal which logged in previously but does not log in currently is also enabled to receive the communication request sent by the calling user, so as to optimize user experience.