Patents by Inventor Jiasheng DIAO

Jiasheng DIAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMODIMERIC BISPECIFIC ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20210371526
    Abstract: Provided is a tetravalent homodimeric bispecific antibody molecule simultaneously targeting an immune effector cell antigen CD3 and a tumor-associated antigen, wherein the bispecific antibody molecule contains, in order from N-terminus to C-terminus, a first single chain Fv, a second single chain Fv and a Fc fragment; wherein the first single chain Fv can specifically bind to the tumor-associated antigen, the second single chain Fv can specifically bind to CD3, and the first and the second single chain Fvs are connected by a linker peptide, while the second single chain Fv and the Fc fragment are directly connected or connected by a linker peptide; and the Fc fragment does not have effector functions such as CDC, ADCC and ADCP.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 2, 2021
    Inventors: Qiang Li, Xinlu Ma, Shixiang Jia, Yuan Yan, Yuhua Zhang, Li Zhou, Rilong Sun, Xueyuan Cui, Lingju Yu, Yujie Yan, Yingying Jin, Yao Xiong, Yuanli Li, Si Chen, Xuemei Liu, Jiasheng Diao
  • SELECTIVE INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L
    Publication number: 20140100184
    Abstract: Structure and mechanism based design was used to design potent ribose containing inhibitors of DOT1L with IC50 values as low as 38 nM. These ribose containing inhibitors exhibit only weak or no activities against four other representative histone lysine and arginine methyltransferases, G9a, SUV39H1, PRMT1 and CARM1.
    Type: Application
    Filed: August 30, 2013
    Publication date: April 10, 2014
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Yongcheng SONG, Pinhong CHEN, Jiasheng DIAO, Gang CHENG, Lisheng DENG, Justin L. ANGLIN, Venkataram B.V. PRASAD, Yang YAO