Abstract: The present disclosure relates to IL 12 receptor agonists with improved therapeutic profiles.

Abstract: A sulfinate glycosyl donor of formula I and a method for preparing same as well as use thereof in preparing a glycoside compound including a thioglycoside compound and a carbon glycoside compound are provided. The sulfinate glycosyl donor has a special sulfinate structure. When the sulfinate glycosyl donor is used as a raw material to prepare the glycoside compound, an additional initiator does not need to be added, such that the production cost is saved, the generation of byproducts is reduced, and the glycoside compound with a purity greater than 98% is obtained. The sulfinate glycosyl donor can be used in the preparation of the glycoside compound such as the thioglycoside compound and the carbon glycoside compound.

Abstract: A method for the glycosylation modification of proteins and/or polypeptides uses glycosyl sulfinate as a raw material. The method for glycosylation and modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups.

Abstract: In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: An electrode plate includes a current collector and a tab. The current collector includes a coated region coated with an active substance layer and an uncoated region not coated with the active substance layer. In a width direction of the current collector, the uncoated region does not surpass the coated region. The tab is connected to the uncoated region.

Abstract: The present application provides a layer-built tab, which includes a plurality of metal pieces and adhesives, the metal pieces being stacked and bonded by the adhesives. The metal pieces are stacked and spaced apart from each other, which increases the heat dissipation area of the tab while supporting a large current flow, the heat dissipation capability of the tab is improved. An electrode plate, a battery core, and a battery including the layer-built tab are also disclosed.

Abstract: A battery not employing soldered joints includes a package case and a first electrode plate disposed in the package case. The first electrode plate includes a current collector for connecting to an active material layer, and the current collector is provided with a plurality of first tab pieces. The first tab pieces are stacked and fixedly connected to form a first tab unit, and the first tab unit extends out of the package case. The disclosed battery reduces the space occupied by the tab unit by directly arranging the tab unit on the current collector of the first electrode plate without soldering an additional tab unit thereto. Energy density of the battery is thus increased.