Abstract: Provided herein is injectable and/or sprayable, in situ polymerizable collagen-based compositions for sustained delivery of therapeutics (active agents, such as drugs, proteins, and other therapeutic agents). The compositions comprise (i) a neutral collagen solution, which is injectable or sprayable and capable of converting into a fibrous collagen mass or gel upon contacting with a physiological fluid or solution, or water; and (ii) a biologically or pharmaceutically active agent in the neutral collagen solution. The compositions are in the form of clear, transparent viscous solutions that instantaneously undergo gelation and polymerization when contacted by physiological fluids or solutions or water. The collagen solutions can be manipulated to provide various rates of sustained delivery of therapeutics.

Abstract: The present disclosure describes a composition for cartilage defects or deficiencies repair, augmentation or treatment comprising an injectable, in situ polymerizable collagen composition and chondrocytes or stem cells in the collagen composition. The present disclosure also relates to methods for repairing or augmenting or treating cartilage defects or deficiencies using the composition and the preparation method of the composition.

Abstract: The present invention describes neutral pH soluble collagen-glycosaminoglycan compositions and methods for augmenting soft tissue defects using the compositions. Soft tissue defects include dermal wrinkles and dermal folds, dermal contour unevenness and laxity and subdermal volume deficiencies. The compositions may also be used for and promoting cellular growth and stimulating tissue regeneration.

Abstract: The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

Abstract: The present disclosure describes a composition for cartilage defects or deficiencies repair, augmentation or treatment comprising an injectable, in situ polymerizable collagen composition and chondrocytes or stem cells in the collagen composition. The present disclosure also relates to methods for repairing or augmenting or treating cartilage defects or deficiencies using the composition and the preparation method of the composition.

Abstract: Proived herein are derivatized or rapidly polymerizing collagen compositions for tissue augmentation containing non-resorbable or slowly resorbable polymers. Also provided are methods for the preparation of the compositions, and methods for augmenting soft tissue utilizing the compositions.

Abstract: Provided herein are hyaluronic acid compositions comprising hyaluronic acid or modified hyaluronic acid or crosslinked hyaluronic acid and slowly resorbable particles, spheres and granules. Also provided are methods for augmenting soft tissue utilizing the compositions.