Abstract: Provided is an oligonucleotide primer with an acyclic nucleoside structure for initial capping, which has a molecular structural formula of m7UNGpppA2?omepG, and has higher mRNA in vitro transcription efficiency, higher capping efficiency, lower immunogenicity and higher protein translation efficiency.

Abstract: In a multi-intent search dialog, according to an embodiment of the invention, a human user and a computerized personal assistant incrementally exchange information to support achievement of multiple tasks of the human user. These multiple tasks can interact, and choices made by the user can be revised, during the course of the dialog. Those revisions can, in turn, lead to modifications in the ongoing specification of other tasks. The approach is a plan-based one in which a dialog between the two agents is viewed as a collaboration involving the tasks under discussion. Based on this approach, there is provided a computer-implemented method and a computerized collaborative dialog manager system for managing a dialog between a computerized personal assistant and a human user.

Abstract: An implantable medical device is capable of delivering therapeutic output to a patient. A controller, programmable by a medical professional, is operatively coupled to the implantable medical device to, in part, program the therapeutic output to be delivered to the patient. The controller has an interface allowing the medical professional to graphically select an amount of the therapeutic output to be delivered to the patient in at least one of a series of discrete timer intervals. The graphic selection may be aided by the use of a light pen or other pointing device to sketch the infusion pattern. Computer programs using algorithms may be utilized to translate the information inputted through the light pen into an infusion program.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that allows a user to troubleshoot a catheter connected to the fluid delivery device by measuring a pressure associated with the catheter. A processor may compare the measured pressure waveform to a previously-acquired waveform or the user interface may display the measured pressure waveform for the user to compare the displayed pressure waveform to a previously-acquired baseline waveform. The comparison between the two waveforms may be based on the pressure decay time. A historical log of measured pressure decays associated with the catheter may be maintained by the programmer device or the implantable fluid delivery device and displayed for the user to determine whether the performance of the catheter is deteriorating.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that allows a user to troubleshoot a catheter connected to the fluid delivery device by measuring a pressure associated with the catheter. A processor may compare the measured pressure waveform to a previously-acquired waveform or the user interface may display the measured pressure waveform for the user to compare the displayed pressure waveform to a previously-acquired baseline waveform. The comparison between the two waveforms may be based on the pressure decay time. A historical log of measured pressure decays associated with the catheter may be maintained by the programmer device or the implantable fluid delivery device and displayed for the user to determine whether the performance of the catheter is deteriorating.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that allows a user to troubleshoot a catheter connected to the fluid delivery device by measuring a pressure associated with the catheter. A processor may compare the measured pressure waveform to a previously-acquired waveform or the user interface may display the measured pressure waveform for the user to compare the displayed pressure waveform to a previously-acquired baseline waveform. The comparison between the two waveforms may be based on the pressure decay time. A historical log of measured pressure decays associated with the catheter may be maintained by the programmer device or the implantable fluid delivery device and displayed for the user to determine whether the performance of the catheter is deteriorating.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that displays a representation of a portion of the implantable fluid delivery device and displays an indication of a location of fluid within the implantable fluid delivery device during a delivery phase, e.g., a priming or bridging phase. The user interface may display a representation of progress of the delivery phase. The user interface may display the indication of the location of the fluid within internal tubing of the implantable fluid delivery device or within a catheter of the implantable fluid delivery device. The programmer device may display the representation of the progress of the delivery phase as a simulation of the delivery phase or during the actual delivery phase of the implantable fluid delivery device. A user may therefore observe a location of fluid corresponding to progress of the delivery phase.

Abstract: A fluid delivery system comprises a pump configured to deliver a therapeutic agent to a patient, a memory storing a therapy program defining the delivery of the therapeutic agent to the patient by the pump and a default infusion schedule based on the therapy program, and a processor configured to control the pump to deliver the therapeutic agent to the patient according to the therapy program, to determine an error condition that prevents the pump from continuing to deliver therapy according to the therapy program, and, upon determination of the error condition, to control the pump to deliver the therapeutic agent to the patient according to the default infusion schedule.

Abstract: An implantable medical device is capable of delivering the therapeutic output to the patient. A controller, programmable by a medical professional, is operatively coupled to the implantable medical device to, in part, program the therapeutic output to be delivered to the patient. The controller has an interface allowing the medical professional to select an amount of the therapeutic output to be delivered to the patient in at least one of the series of discrete timer intervals. However, the therapeutic output deliver to the patient is dependant upon the clock time to which the infusion device. In certain situations the infusion device clock time may have inaccuracies that grow over time. The clock time can be reset by the infusion programmer but a method must be in place to determine and account for resetting the infusion device clock time that controls when the therapy will be delivered.

Abstract: A fluid delivery system comprises a pump configured to deliver a therapeutic agent to a patient, a memory storing a therapy program defining the delivery of the therapeutic agent to the patient by the pump and a default infusion schedule based on the therapy program, and a processor configured to control the pump to deliver the therapeutic agent to the patient according to the therapy program, to determine an error condition that prevents the pump from continuing to deliver therapy according to the therapy program, and, upon determination of the error condition, to control the pump to deliver the therapeutic agent to the patient according to the default infusion schedule.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that allows a user to troubleshoot a catheter connected to the fluid delivery device by measuring a pressure associated with the catheter. A processor may compare the measured pressure waveform to a previously-acquired waveform or the user interface may display the measured pressure waveform for the user to compare the displayed pressure waveform to a previously-acquired baseline waveform. The comparison between the two waveforms may be based on the pressure decay time. A historical log of measured pressure decays associated with the catheter may be maintained by the programmer device or the implantable fluid delivery device and displayed for the user to determine whether the performance of the catheter is deteriorating.

Abstract: Techniques are described for simultaneously displaying representations, such as graphical representations, of both a selected dosing program of an implantable fluid delivery device and a pending dosing program of the implantable fluid delivery device. In one example, a system includes an implantable fluid delivery device that delivers fluid to a patient according to a selected dosing program, and a programmer device that includes a user interface comprising a display to present a graphical representation of doses of fluid to be delivered to a patient via an implantable fluid delivery device, and a processor that controls the user interface to simultaneously present on the display a first indication of a selected dosing program of the implantable fluid delivery device and a second indication of a pending dosing program of the implantable fluid delivery pump. A user may therefore compare the selected dosing program with the pending dosing program.

Abstract: A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that displays a representation of a portion of the implantable fluid delivery device and displays an indication of a location of fluid within the implantable fluid delivery device during a delivery phase, e.g., a priming or bridging phase. The user interface may display a representation of progress of the delivery phase. The user interface may display the indication of the location of the fluid within internal tubing of the implantable fluid delivery device or within a catheter of the implantable fluid delivery device. The programmer device may display the representation of the progress of the delivery phase as a simulation of the delivery phase or during the actual delivery phase of the implantable fluid delivery device. A user may therefore observe a location of fluid corresponding to progress of the delivery phase.

Abstract: An implantable medical device is capable of delivering therapeutic output to a patient. A controller, programmable by a medical professional, is operatively coupled to the implantable medical device to, in part, program the therapeutic output to be delivered to the patient. The controller has an interface allowing the medical professional to graphically select an amount of the therapeutic output to be delivered to the patient in at least one of a series of discrete timer intervals. The graphic selection may be aided by the use of a light pen or other pointing device to sketch the infusion pattern. Computer programs using algorithms may be utilized to translate the information inputted through the light pen into an infusion program.

Abstract: An implantable medical device is capable of delivering the therapeutic output to the patient. A controller, programmable by a medical professional, is operatively coupled to the implantable medical device to, in part, program the therapeutic output to be delivered to the patient. The controller has an interface allowing the medical professional to select an amount of the therapeutic output to be delivered to the patient in at least one of the series of discrete timer intervals. However, the therapeutic output deliver to the patient is dependant upon the clock time to which the infusion device. In certain situations the infusion device clock time may have inaccuracies that grow over time. The clock time can be reset by the infusion programmer but a method must be in place to determine and account for resetting the infusion device clock time that controls when the therapy will be delivered.