Abstract: A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.

Abstract: An urban flooding prevention method includes: inverting the global water depth and the flow rate of the rainwater system, generating the urban flooding inundation map and the binary flooded grid at the monitoring time, and performing a rationality check of the global water depth of the rainwater system, the urban flooding inundation map and the binary flooded grid, performing a fusion processing based on the hydraulic connection between the 1D node and the 2D ground to obtain a label, and generating a new data set according to the label and the forecast rainfall, mixing the historical data set and the new data set to obtain a mixed data set, and using the updated model to predict the urban flooding, according to the prediction results, determining the early warning level of urban flooding, so as to generate the drainage scheme, and regulating the corresponding drainage facilities according to the drainage scheme.

Abstract: A control method includes performing multi-level classification processing on distributed energy resources to obtain corresponding power supply equipment, power storage equipment, and hybrid equipment, analyzing and processing power distribution data and load data in the smart grid to obtain a power distribution demand of the smart grid, and dividing the smart grid into different division areas, determining corresponding power supply equipment, power storage equipment, or hybrid equipment in accordance with the power distribution demand and the division areas, and performing storage regulation and control on the corresponding power supply equipment, power storage equipment, or hybrid equipment, and if it is determined that the power supply equipment, power storage equipment, or hybrid equipment has a manner of multi-resource participation in the storage regulation and control, adding different multi-resource participation pricing strategies for power supply equipment, power storage equipment, or hybrid equipm

Abstract: The present invention relates the field of animal health. Particularly, the present invention relates to a recombinant classical swine fever virus E2 protein in which a fragment comprising at least one of the amino acids defining the 6B8 epitope of the CSFV E2 protein is replaced by a corresponding fragment of the E2 protein from a pestivirus other than CSFV. Further, the present invention provides an immunogenic composition comprising the recombinant E2 protein of the present invention and the use of the immunogenic composition for preventing and/or treating diseases associated with CSFV in an animal. Moreover, the present invention provides a method and a kit for differentiating animals infected with CSFV from animals vaccinated with the immunogenic composition of the present invention.

Abstract: A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they als show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.

Abstract: The present invention relates to the field of animal health. Particularly, the present invention relates to a recombinant classical swine fever virus E2 protein comprising at least one mutation at the epitope specifically recognized by the 6B8 monoclonal antibody. Further, the present invention provides an immunogenic composition comprising the recombinant E2 protein of the present invention and the use of the immunogenic composition for preventing and/or treating diseases associated with CSFV in an animal. Moreover, the present invention provides a method and a kit for differentiating animals infected with CSFV from animals vaccinated with the immunogenic composition of the present invention. Furthermore, the present invention provides a method of producing the E2 protein.

Abstract: Provided are a recombinant classical swine fever virus comprising at least one substitution within the epitope of the E2 protein specifically recognized by the 6B8 monoclonal antibody, an immunogenic composition comprising said CSFV, the use of said immunogenic composition for preventing and/or treating diseases associated with CSFV in an animal, a method or a kit for differentiating animals infected with CSFV from animals vaccinated with said immunogenic composition, and an attenuated classical swine fever viruses.

Abstract: The present disclosure discloses a new use of desloratadine (DLT) and pharmaceutically acceptable salts thereof in preparing a drug for treating a neurodegenerative disease related to motor dysfunction. The present disclosure shows, through a large number of experimental tests, that desloratadine and the pharmaceutically acceptable salts thereof can improve the state of motor dysfunction in an SOD1-G93A model mouse in the behavioral experimental tests of Rotarod experimental test, gait monitoring experimental test and cage experimental test, and that desloratadine and the pharmaceutically acceptable salts thereof can effectively delay the onset time and prolong the survival cycle of the SOD1-G93A model mouse, and therefore, desloratadine and the pharmaceutically acceptable salts thereof can be used to treat neurodegenerative diseases related to motor dysfunction, including amyotrophic lateral sclerosis.

Abstract: Provided a recombinant classical swine fever virus E2 protein comprising at least one mutation at the epitope specifically recognized by the 6B8 monoclonal antibody. Further, the present invention provides an immunogenic composition comprising the recombinant E2 protein of the present invention and the use of the immunogenic composition for preventing and/or treating diseases associated with CSFV in animal. Moreover, the present invention provides a method and a kit for differentiating animals infected with CSFV from animals vaccinated with the immunogenic composition of the present invention.

Abstract: A method comprises depositing forming a first oxide layer comprising a bottom surface in contact with a first electrode, positioning a template at a specified position on a top surface of the first oxide, the template comprising a plurality of nanopores that extend through the template, depositing a metal material into at least a portion of the plurality of nanopores, allowing the metal material to at least partially solidify in at least the portion of the plurality of nanopores to form nanostructures in contact with the first oxide top surface, separating the template from the first oxide layer and the nanostructures, forming a second oxide layer comprising a bottom surface in contact with the first oxide top surface and the nanostructures, and forming a second electrode in electrical contact with at least a portion of a top surface of second oxide top surface.

Abstract: The present invention relates to application of drofenine or a pharmaceutically acceptable salt thereof in the preparation of medicine for treating peripheral neuron axonal injury and peripheral related neuropathy. The drofenine or the pharmaceutically acceptable salt thereof has a significant effect on promoting growth of peripheral sensory neurites, and can relieve symptoms of low nerve conduction velocity and sensation loss of STZ-induced type I diabetic mice and db/db type II diabetic mice, thereby treating diabetic peripheral neuropathy.

Abstract: The present invention relates to a method for tracking and locating a contamination source in a water distribution system based on consumer complaints, comprising following steps: S1: generating a contamination matrix by location information complained by consumers; S2: determining similarity between candidate nodes and classifying the candidate nodes; S3: adding a random complaint hysteresis time and constructing a consumer complaint sample; and S4: training, validating and testing a convolutional neural network by the consumer complaint sample, and using the convolutional neural network in practically tracking and locating a contamination source. Compared with the prior art, the present invention has the following advantages. The contamination source is located in the consumer complaint pattern, according to the real-time consumer complaints after a contamination accident occurs.

Abstract: A method comprises depositing forming a first oxide layer comprising a bottom surface in contact with a first electrode, positioning a template at a specified position on a top surface of the first oxide, the template comprising a plurality of nanopores that extend through the template, depositing a metal material into at least a portion of the plurality of nanopores, allowing the metal material to at least partially solidify in at least the portion of the plurality of nanopores to form nanostructures in contact with the first oxide top surface, separating the template from the first oxide layer and the nanostructures, forming a second oxide layer comprising a bottom surface in contact with the first oxide top surface and the nanostructures, and forming a second electrode in electrical contact with at least a portion of a top surface of second oxide top surface.

Abstract: The present invention provides a wavelength division multiplexing system and a method and device for its residual dispersion compensation, wherein the device for residual dispersion compensation of wavelength division multiplexing system comprises: a performance parameter detecting device for receiving and detecting performance parameter of receiving terminal optical signal and sending detecting result of the performance parameter to a central control device; the central control device for deciding a dispersion regulating mode of a tunable dispersion compensator according to the detecting result of the performance parameter and sending the dispersion regulating mode to a tunable dispersion compensator control device through control signaling; and the tunable dispersion compensator control device for receiving the control signaling sent by the central control device and adjusting dispersion compensation amount of the tunable dispersion compensator according to the control signaling in order to make residual di

Abstract: The present invention provides a wavelength division multiplexing system and a method and device for its residual dispersion compensation, wherein the device for residual dispersion compensation of wavelength division multiplexing system comprises: a performance parameter detecting device for receiving and detecting performance parameter of receiving terminal optical signal and sending detecting result of the performance parameter to a central control device; the central control device for deciding a dispersion regulating mode of a tunable dispersion compensator according to the detecting result of the performance parameter and sending the dispersion regulating mode to a tunable dispersion compensator control device through control signaling; and the tunable dispersion compensator control device for receiving the control signaling sent by the central control device and adjusting dispersion compensation amount of the tunable dispersion compensator according to the control signaling in order to make residual di