Abstract: Methods and systems for determining a plurality of sequences of nucleic acid (e.g., DNA) molecules in a sequencing-by-synthesis process are provided. In one embodiment, the method comprises obtaining images of fluorescent signals obtained in a plurality of synthesis cycles. The images of fluorescent signals are associated with a plurality of different fluorescence channels. The method further comprises preprocessing the images of fluorescent signals to obtain processed images. Based on a set of the processed images, the method further comprises detecting center positions of clusters of the fluorescent signals using a trained convolutional neural network (CNN) and extracting, based on the center positions of the clusters of fluorescent signals, features from the set of the processed images to generate feature embedding vectors. The method further comprises determining, in parallel, the plurality of sequences of DNA molecules using the extracted features based on a trained attention-based neural network.

Abstract: The present disclosure relates to a system and method for image registration and image subtraction. The technique includes perform acquiring data related to the image processing, performing a pre-processing of the images, performing an image registration, performing an image subtraction, performing a post-processing of the images and managing storage of the data.

Abstract: The present disclosure relates to a system and method for image registration and image subtraction. The technique includes perform acquiring data related to the image processing, performing a pre-processing of the images, performing an image registration, performing an image subtraction, performing a post-processing of the images and managing storage of the data.

Abstract: The present disclosure relates to a system and method for image registration and image subtraction. The technique includes perform acquiring data related to the image processing, performing a pre-processing of the images, performing an image registration, performing an image subtraction, performing a post-processing of the images and managing storage of the data.

Abstract: The present disclosure relates to a system and method for image registration and image subtraction. The technique includes perform acquiring data related to the image processing, performing a pre-processing of the images, performing an image registration, performing an image subtraction, performing a post-processing of the images and managing storage of the data.