Abstract: The present application provides a method for preparing nintedanib. The method of the present application is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw materials, and preparing nintedanib via intermediates of methyl 4-(1-alkoxy-1,3-dioxo-3-phenyl propan-2-yl)-3-nitrobenzoate (compound IV) and methyl 3-benzoyl-2-oxoindoline-6-formate (compound V). The method for preparing nintedanib (I) provided by the present application has the advantages of using easily obtained raw materials, having a simple process, being cost effective and environmentally friendly, and is suitable for industrial-scale production.

Abstract: The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly performing a “one-pot” reaction on a compound I, compound J or compound L without performing isolation, wherein a salt of a compound K is selected from a hydrochloride, sulfate, malate, tartrate, p-toluenesulfonate, or lactate, and wherein the symbol * in a compound indicates an atom of an R-type chirality or an S-type chirality or a racemate thereof.

Abstract: The present application provides a method for preparing nintedanib. The method of the present application is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw materials, and preparing nintedanib via intermediates of methyl 4-(1-alkoxy-1,3-dioxo-3-phenyl propan-2-yl)-3-nitrobenzoate (compound IV) and methyl 3-benzoyl-2-oxoindoline-6-formate (compound V). The method for preparing nintedanib (I) provided by the present application has the advantages of using easily obtained raw materials, having a simple process, being cost effective and environmentally friendly, and is suitable for industrial-scale production.

Abstract: The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure as shown in Formula C and a compound having a structure as shown in Formula D by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, and sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy.

Abstract: Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method of (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups; IV-A: R1 and R2 are independently selected from C1-C7 alkyl groups, and R1 and R2 are not both benzyl groups.

Abstract: The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure as shown in Formula C and a compound having a structure as shown in Formula D by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, and sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy.

Abstract: The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly performing a “one-pot” reaction on a compound I, compound J or compound L without performing isolation, wherein a salt of a compound K is selected from a hydrochloride, sulfate, malate, tartrate, p-toluenesulfonate, or lactate, and wherein the symbol * in a compound indicates an atom of an R-type chirality or an S-type chirality or a racemate thereof.

Abstract: A driving force control apparatus for a vehicle includes a first sensor that detects an output command supplied to a power source, a second sensor that detects an operating condition amount of a vehicle and a controller. The controller calculates a basic command value of an output of the power source based upon the output command from the first sensor, calculates a reference model command value based upon the basic command value and transmission characteristic of a response of reference model, calculates a correction value from a deviation between the reference model command value and a predetermined frequency component corresponding to a vibration of a vehicle driving system extracted out of the operating condition amount of the vehicle, and calculates a target command value based upon the basic command value and the correction value to control the torque of the power source.

Abstract: An electronically controlled hydraulic brake system is configured to obtain an attainment brake hydraulic pressure which can be achieved when a motor drive current command value is applied to a pressure increasing pump motor, to set a virtual initial pressure of the brake hydraulic pressure, to obtain a linear compensation executed attainment brake hydraulic pressure by linearly compensating the attainment brake hydraulic pressure using the actual brake hydraulic pressure, to calculate an ideal flow rate of the pressure increasing pump from a hydrodynamic flow rate equation, to obtain the linear compensation executed attainment brake hydraulic pressure by executing an inverse calculation of the flow rate equation from the ideal flow rate and the actual brake hydraulic pressure, and to obtain a linear compensation executed motor drive current command value by executing an inverse calculation of the calculation for obtaining the linear compensation executed attainment brake hydraulic pressure.

Abstract: A driving force control apparatus for a vehicle includes a first sensor that detects an output command supplied to a power source, a second sensor that detects an operating condition amount of a vehicle and a controller. The controller calculates a basic command value of an output of the power source based upon the output command from the first sensor, calculates a reference model command value based upon the basic command value and transmission characteristic of a response of reference model, calculates a correction value from a deviation between the reference model command value and a predetermined frequency component corresponding to a vibration of a vehicle driving system extracted out of the operating condition amount of the vehicle, and calculates a target command value based upon the basic command value and the correction value to control the torque of the power source.

Abstract: An electronically controlled hydraulic brake system is configured to obtain an attainment brake hydraulic pressure which can be achieved when a motor drive current command value is applied to a pressure increasing pump motor, to set a virtual initial pressure of the brake hydraulic pressure, to obtain a linear compensation executed attainment brake hydraulic pressure by linearly compensating the attainment brake hydraulic pressure using the actual brake hydraulic pressure, to calculate an ideal flow rate of the pressure increasing pump from a hydrodynamic flow rate equation, to obtain the linear compensation executed attainment brake hydraulic pressure by executing an inverse calculation of the flow rate equation from the ideal flow rate and the actual brake hydraulic pressure, and to obtain a linear compensation executed motor drive current command value by executing an inverse calculation of the calculation for obtaining the linear compensation executed attainment brake hydraulic pressure.