Abstract: Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.

Abstract: Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.

Abstract: Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.

Abstract: Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.

Abstract: Novel GPCR GAVE10 polypeptides, proteins and nucleic acid molecules are provided. GAVE10, recombinant expression vectors, host cells incorporating GAVE10 expression vectors and non-human transgenic animals into which a GAVE10 gene has been introduced or disrupted are taught. Diagnostic, screening and therapeutic methods utilizing compositions of the invention also are provided.

Abstract: Disclosed is a method for inhibiting TNF?, IL-6, and activating GAVE10, treating, for example, inflammation thereby, the method comprising the step of administering to a subject an effective amount of a compound of the following formula: or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein B1 and B2 are each independently —OH, (C1-C6)alkyl, or —H; X is Z-K; Z is —CO or —CH2; K is —N(R1)n, —NR1N(R2)n, —NR1R5R2R4, —N(R1)pR2NR3R4, or —N(R1)pR5R2R4 R1, R2, and R3 are each independently (C1-C6)alkyl or absent; n is from 0 to 3; p is from 0 to 2; R4 is absent or is R5 is absent or is

Abstract: Novel GAVE10 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE10 proteins, isolated GAVE10 fusion proteins, antigenic peptides and anti-GAVE10 antibodies are taught.

Abstract: Novel GAVE2 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE2 proteins, isolated GAVE2 fusion proteins, antigenic peptides and anti-GAVE2 antibodies are taught.

Abstract: Novel GAVE17 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE17 proteins, isolated GAVE17 fusion proteins, antigenic peptides and anti-GAVE17 antibodies are taught.

Abstract: Novel GAVE7 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE7 proteins, isolated GAVE7 fusion proteins, antigenic peptides and anti-GAVE7 antibodies are taught.

Abstract: Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunologically related diseases and disorders.

Abstract: Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunologically related diseases and disorders.

Abstract: Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunological related diseases and disorders.