Abstract: Non-linear multiblock copolymer-drug conjugates for the treatment and prevention of diseases and disorders of the eye are provided. The polymer-drug conjugates can form nanoparticles, microparticles, and implants that are capable of effectively delivering therapeutic levels of one or more active agents for an extended period of time. Administration to the eye of an active agent in the form of a non-linear multiblock copolymer-drug conjugate produces decreased side effects when compared to administration of the active agent alone. Also provided are methods of treating intraocular neovascular diseases, such as wet age-related macular degeneration as well as diseases and disorders of the eye associated with inflammation, such as uveitis.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, and provide results of the automated analysis in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria or rules so as to generate a compact, human-readable analysis of the data clusters. The human-readable analyses (also referred to herein as “summaries” or “conclusions”) of the data clusters may be organized into an interactive user interface so as to enable an analyst to quickly navigate among information associated with various data clusters and efficiently evaluate those data clusters in the context of, for example, a fraud investigation. Embodiments of the present disclosure also relate to automated scoring of the clustered data structures.

Abstract: A power converter comprises a switch arrangement for controlling a path of current flow through an energy storage element and power commutation thereof so as to provide an output. The switch arrangement comprises at least first and second MOSFETs connected in series and a controlling circuit for determining how the first and second MOSFETs are switched. The timing of operation of the switching arrangement is used to control the output of the power converter. An adjusting circuit is used to adjust an electrical parameter of a component of the controlling circuit according to an operating condition of the power converter, thereby to control an efficiency of the power converter under different operating conditions.

Abstract: A population of polymeric particles for controlled release of therapeutic agents which have unacceptable toxicity when administered intravitreally can be safely administered suprachoroidally at the same intravitreal concentration or dose. In a preferred embodiment, the particles have a high loading of the agent and is released without a substantial initial burst release. Examples demonstrate safety and efficacy of delivery of acriflavine-containing particles when administered suprachoroidally. The examples demonstrate sustained release with low to no burst release of the highly water soluble agent for up to 60 days.

Abstract: The invention provides an olefin-olefinic alcohol copolymer and a preparation method thereof, said copolymer comprising a spherical and/or spherical-like polymer. The copolymer provided by the invention exhibits a good morphology and has good prospects in industrial use.

Abstract: An LED driver that is operable with two different types of power source originally designed for a high-intensity discharge lamp. The LED driver directs current of an input power provided by the power source down a first current path if it is determined that the power source comprises a functional ignitor. The LED driver directs current of an input power provided by the power source down a second current path if it is determined that the 5 power source does not comprise a functional ignitor.

Abstract: Embodiments of the present disclosure relate to a data analysis system that may automatically generate memory-efficient clustered data structures, automatically analyze those clustered data structures, and provide results of the automated analysis in an optimized way to an analyst. The automated analysis of the clustered data structures (also referred to herein as data clusters) may include an automated application of various criteria or rules so as to generate a compact, human-readable analysis of the data clusters. The human-readable analyses (also referred to herein as “summaries” or “conclusions”) of the data clusters may be organized into an interactive user interface so as to enable an analyst to quickly navigate among information associated with various data clusters and efficiently evaluate those data clusters in the context of, for example, a fraud investigation. Embodiments of the present disclosure also relate to automated scoring of the clustered data structures.

Abstract: A device for determining a type of a power source for powering a LED lighting unit, wherein one possible type comprises a ballast originally designed for a high intensity discharge lamp and repurposed for use with an LED lighting unit. The power source type determiner monitors at least one electrical parameter of either a load or the power source itself after a power drawn by the load whose characteristic is set to a critical value. A value of the electrical parameter is used to identify a type of the power source. A value of the electrical parameter is the pulse generated by the traditional ballast for gas discharge lamp, which pulse is detected to determine the type of the power source.

Abstract: A method for preparing an olefin-olefinic alcohol copolymer and an olefin-olefinic alcohol copolymer prepared by the method are provided. The catalyst used in the method for preparing the olefin-olefinic alcohol copolymer has a diimine metal complex as shown in Formula I.

Abstract: An LED driver for an LED lamp, which also comprises an LED load. The LED driver is adapted to connect to an input source at a first and second terminal. The LED driver comprises a switching arrangement configured to enable a controller to control at least a magnitude and phase of the voltage between the first and second terminals. The phase of the voltage between the first and second terminals may be defined to control an amount of power that flows from the input source to power the LED lamp.

Abstract: One variation of a method for producing a smart yarn includes: aligning a set of sensing elements offset along a lateral axis in a magazine, wherein each sensing element in the set of sensing elements includes a sensor, a first conductive lead extending from a first side of the sensor along a longitudinal axis perpendicular to the lateral axis, and a second conductive lead extending from a second side of the sensor opposite the first side and along the longitudinal axis; wrapping a set of fibers into a yarn within a wrapping field; feeding a leading end of a first sensing element, in the set of sensing elements, from the magazine into the wrapping field; releasing the first sensing element from the magazine into the wrapping field; encasing the first sensing element between the set of fibers within the yarn; and repeating this process for the set of sensing elements.

Abstract: Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. Studies demonstrate that nanoparticle delivery of BPTES, relative to use of BPTES alone, can be safely administered and provides dramatically improved tumor drug exposure, resulting in greater efficacy. GLS inhibitors can be administered in higher concentrations with sub-100 nm nanoparticles, since the nanoparticles package the drug into “soluble” colloidal nanoparticles, and the nanoparticles deliver higher drug exposure selectively to the tumors due to the enhanced permeability and retention (EPR) effect. These factors result in sustained drug levels above the IC50 within the tumors for days, providing significantly enhanced efficacy compared to unencapsulated drug.

Abstract: A driver arrangement is provided for a LED lighting device with a LED light source and at least one additional auxiliary module. The driver arrangement comprises separate main and auxiliary drivers. The delivery of power from the auxiliary driver is controlled to either an auxiliary power output or to both a main power output and the auxiliary power output. Each driver can be optimized for the load it is required to drive. The device may overall be more efficient in a low power auxiliary mode, by using a driver suited for such low power operation. In particular when the power demand of the LED light source is low, the auxiliary driver may be used.

Abstract: One variation of a method for producing a smart yarn includes: aligning a set of sensing elements offset along a lateral axis in a magazine, wherein each sensing element in the set of sensing elements includes a sensor, a first conductive lead extending from a first side of the sensor along a longitudinal axis perpendicular to the lateral axis, and a second conductive lead extending from a second side of the sensor opposite the first side and along the longitudinal axis; wrapping a set of fibers into a yarn within a wrapping field; feeding a leading end of a first sensing element, in the set of sensing elements, from the magazine into the wrapping field; releasing the first sensing element from the magazine into the wrapping field; encasing the first sensing element between the set of fibers within the yarn; and repeating this process for the set of sensing elements.

Abstract: A diimine metal complex represented by Formula I, a preparation method therefor, and application thereof are provided. The complex is used as a main catalyst in catalysts for olefin polymerization, and can achieve catalytic ethylene polymerization at a high temperature to prepare high molecular weight branched polyethylene.

Abstract: A Multiple-Input Multiple-Output (MIMO) device comprises an array of multiple antennas and a circuitry configured to receive, using the array of multiple antennas, a plurality of calibration signals from a plurality of proximate wireless MIMO devices, calibrate the wireless MIMO device based on the received calibration signals and based on known directions from the wireless MIMO device to each of the proximate wireless MIMO devices, and drive the array of multiple antennas to emit a beam-formed calibration signal to each of the proximate wireless devices in order to enable each of the proximate wireless MIMO devices to calibrate itself.

Abstract: A device is configured to calculate a set of channel estimates for a plurality of sub-carriers based on a plurality of pilot-symbols and/or data-symbols carried by said plurality of sub-carriers; calculate a set of equalizers for the plurality of sub-carriers based on the set of channel estimates; perform an equalization on a plurality of data-symbols using the set of equalizers for obtaining a plurality of equalized symbols; perform a soft-slicing or hard-slicing procedure comprising obtaining a plurality of estimated symbols based on the equalized symbols; calculate at least one diagonal-loaded interference-plus-noise covariance matrix, based on the set of estimated symbols; de-map the plurality of data symbols to soft-bits, based on the at least one diagonal-loaded interference-plus-noise covariance matrix, the set of channel estimates or an updated version thereof; and feed the soft-bits to a channel decoder.

Abstract: A radio station, in particular an access point, for client localization in a multipath indoor environment is disclosed. The radio station comprises: a circular antenna array comprising uniform circularly arranged antenna elements; and a processor configured to: transform first input data from the circular antenna array into second input data using a transform that transforms the first steering vector of the circular antenna array into a second steering vector of a virtual linear antenna array; and transform the second input data into third input data by using a transform that transforms the second steering vector of the virtual linear antenna array into a third steering vector of a second virtual linear antenna array, comprising a larger number of antenna elements than the virtual linear antenna array; and determine an angle of arrival based on the third input data.

Abstract: A system for monitoring a user includes a garment configured to be placed on a foot of the user, a cover coupled to the garment, and a sensor arrangement between the garment and the cover, wherein the sensor arrangement comprises at least one temperature sensor to measure at least one temperature on the foot of the user. A method for making a system for monitoring a user includes forming a sensor arrangement including at least one sensor lead coupled to a temperature sensor, positioning at least a portion of the sensor arrangement on a garment configured to be placed on a foot of the user, and enclosing at least the portion of the sensor arrangement between the garment and a cover.

Abstract: Provided is a dielectric body having a high dielectric constant and a change rate of the dielectric constant of 30% or less, in a temperature range from ?50° C. to 350° C. An inorganic substance contains an oxide crystal including A and M (the A being one or more of P, Ge, and V, and the M being one or more of Nb and Ta), wherein the dielectric constant is 500 or more. In the inorganic substance, the oxide crystal is one or more of PNb9O25, P2.5Nb18O50 and GeNb9O25, GeNb18O47, GeNb19.144O50, VNb9O25, VNb9O24.9, PTa9O25, GeTa9O25, VTa9O25, and solid solutions thereof.