Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds of the present disclosure are inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). The compounds may be selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds. The compounds may be useful in inhibiting the activity of a kinase, down-regulating the transcription of MYC or MCL-1, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis).

Abstract: A method for reducing the risk of burning and explosion in a deoxygenation process of an oxygen-containing gas includes multiple steps. According to this method, in the presence of a gaseous alkane, hydrogen reacts with an oxygen-containing gas from which an unsaturated hydrocarbon has been removed. The oxygen-containing gas contains the oxygen and the unsaturated hydrocarbon, and the content of the oxygen in the oxygen-containing gas is greater than 0.5% by volume. A gaseous alkane is introduced to reduce the risk of burning and explosion of a mixed gas. A hydrocatalytic reaction is carried out to promote oxygen in the mixed gas to react with hydrogen to produce water, which removes oxygen from the oxygen-containing gas and also effectively inhibits carbon deposition on the surface of a catalyst and the production of a carbon oxide, which enhances the toleration for fluctuation of the oxygen content in a raw gas.

Abstract: Provided is an efficient and energy-saving building slurry stirring device. The device includes a grouting assembly, which includes a base, a storage tank, a discharge pipe, a grouting pump and a control box. The storage tank is arranged at the top of the base, the discharge pipe is located at one side of the storage tank, the grouting pump is arranged on the discharge pipe, and the control box is fixed to the top of the base. When the fluidity of a grouting material in the storage tank is reduced due to solidification, the stirring assembly can stir the grouting material in the storage tank. Then, the stirring assembly stops stirring the grouting material to save energy. After the grouting is completed, an inner wall of the storage tank can be cleaned by the stirring assembly.

Abstract: A data processing method includes: acquiring a first intersection set, acquiring a second intersection set, calculating an intersection between the first intersection set and the second intersection set to obtain an intersection result set that includes an intersecting portion of the first intersection data and the second intersection data, and obfuscating the intersection result set to obtain an obfuscation set that includes obfuscated data based on data in the second intersection set and an intersection data set based on the intersection result set.

Abstract: A method for federated data query includes: using, by a first electronic device, a joint query statement corresponding to a federated data query to obtain at least one operator containing a joint query operator; transforming the joint query operator to a first joint security operator; determining first data for intersection on the first electronic device by executing the first joint security operator, receiving second data for intersection from a second electronic device involved in the federated data query, and performing joint computing on the first data for intersection and the second data for intersection in a form of a ciphertext to obtain a joint data table; and determining a federated data query result corresponding to the at least one operator based on the joint data table.

Abstract: Methods, apparatus, computer devices, products, and storage medium are described for generating tree-structure storage data for a graph structure, applicable to the fields of cloud computing or the Vehicle of Internet. One method includes: obtaining data of a graph structure comprising vertex data of at least one vertex of the graph structure and edge data of at least one edge of the graph structure; constructing memory data of a tree structure for the data of the graph structure in a memory of the computer device; constructing a plurality of disk blocks in a storage device based on the memory data of the tree structure; and storing the data of the root node, the data of each first-subnode, and data of a subtree using each second-subnode as a root node into corresponding disk blocks respectively, to obtain the storage data of the tree structure for the graph structure.

Abstract: The present invention relates to the field of energy chemical industry, and disclosed are a gliding arc plasma reactor, and a method for converting methane by means of plasma. The reactor comprises a reactor chamber and a gliding arc plasma generator arranged in the reactor chamber, wherein the gliding arc plasma generator comprises at least two arc surface electrodes which are symmetrically distributed, such that a discharge area can be formed between the arc surface electrodes. According to the gliding arc plasma reactor provided in the present invention, the conversion rate of methane can be significantly improved when methane is converted into olefin; the selectivity of ethylene in the product is improved; and carbon deposition is significantly reduced. In addition, compared with a traditional process for preparing olefin from methane, no CO2 is generated; the ignition and explosion risk is avoided; and the reactor is safer and more environmentally friendly.

Abstract: An embodiment parses, by a host plugin, a host content view into a plurality of host resources. The embodiment identifies, by an attendee plugin, an attendee interaction with a host resource in the plurality of host resources. The embodiment transmits, by the attendee plugin, based on the attendee interaction, a resource request for the host resource. The embodiment transmits, by the host plugin, based on the resource request, a host resource content associated with the host resource. The embodiment executes, by the attendee plugin, based on the host resource content, a response action for presenting the host resource content.

Abstract: According to an exemplary embodiment of the present invention, a method is provided. The method includes identifying UI controls in a GUI for display on a screen of a computing device. The method further includes determining a position relationship of the UI controls. The method further includes mapping the UI controls to keyboard areas such that a position relationship of the keyboard areas corresponds with the position relationship of the UI controls. One or more keys within the individual areas are associated with the UI controls that are mapped to the respective keyboard areas.

Abstract: A semiconductor device manufacturing method includes the following steps. A well implant process is performed on a region of a substrate. A source/drain implant process is performed on the region of the substrate. An active area is defined on the region of the substrate. Shallow trench isolations are formed in the active area. An annealing process is performed to the region of the substrate.

Abstract: Embodiments of the present disclosure provide systems and methods for implementing an intelligent vehicle-collision simulation sandbox and intelligently analyzing behaviors of surrounding objects with a current vehicle to simulate possible collisions of the current vehicle and surrounding objects and display intelligently calculated collision probabilities of the surrounding objects.

Abstract: The present invention relates to compounds, compositions, and methods for treating diseases or conditions by modulating (e.g., reducing) the level or activity of at least one of PIP4K2A, PIP4K2B, and PIP4K2C.

Abstract: A data query request processing method is provided. In the method, a node device receives a data query request transmitted by another node device for querying data related to a first vertex in a graph database through a first processing model. The data query request carries an identifier of a start vertex. The node device transmits the data query request to a second processing model through the first processing model. The second processing model is configured to process data of the start vertex. The node device determines a third processing model based on the data query request through the second processing model, the third processing model being configured to process data of the first vertex or an intermediate vertex between the start vertex and the first vertex. The node device transmits the data query request to the third processing model through the second processing model.

Abstract: Disclosed is an antibody capable of binding to the interleukin 4 (IL-4) receptor (IL-4). Also disclosed are a nucleic acid sequence encoding the antibody, a vector including the nucleic acid sequence, and a host cell transformed or transfected with the vector. Provided are a method for producing the antibody, a medical use of the antibody, and a kit including the antibody.

Abstract: A tool attachment device for assisting a power tool in performing nailing includes a shell assembly, a rocker, a connection device, a driving wheel, and a transmission assembly. A side of the shell assembly is formed with a hole passage. The rocker is partially placed in the hole passage and is rotatable in the hole passage. The connection device is connected to the rocker and rotates synchronously with the rocker. Nail feeding structures are formed on the driving wheel along a circumferential direction of the driving wheel. The transmission assembly is connected to the driving wheel and the connection device and is configured to drive the driving wheel to rotate unidirectionally. The transmission assembly is disposed between the connection device and the driving wheel.

Abstract: The disclosure discloses stabilized rice aleurone and a preparation method, using the technology of classifying a rice aleurone layer by a tangential injection airflow impeller classifier combined with an ultrasonic vibrating screen for the first time, and simultaneously uses steam treatment coupled with thermal enzyme inactivation by drum drying as a stabilization method to prepare the stabilized rice aleurone for the first time. The drum drying equipment realizes the two purposes of enzyme inactivation and drying, and the method has the advantages of short process flow, simple equipment, high utilization rate, small floor space, low investment, low energy consumption and no pollution, and is suitable for industrial promotion. The stabilized rice aleurone has high nutritional value, is rich in functional ingredients, and can be used as a raw material for functional food development in industrial production and food applications.

Abstract: Techniques are described with respect to a system, method, and computer product for visualizing viewpoints. An associated method includes receiving access to a multi-party discussion occurring via a telecommunication system and analyzing the multi-party discussion using natural language processing. The method further includes extracting a plurality of viewpoints of the multi-party discussion based on the analysis, synthesizing a subset of the plurality of viewpoints based on the content of each viewpoint of the plurality of viewpoints, and transmitting a rendered synthesized visualization of the subset.

Abstract: A nail gun includes: a housing; an accessory box for accommodating a fastener and at least partially connected to the housing; and a power output portion for outputting a striking force to the fastener; and an operating member triggered to have at least a first position and a second position, where the nail gun has a maximum desired penetration depth when the operating member is operated to the first position, and the nail gun has a minimum desired penetration depth when the operating member is operated to the second position; and when the operating member switches from the first position to the second position, an angle by which the operating member rotates about a first straight line is less than or equal to 360°.

Abstract: Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.

Abstract: The present invention relates to a microplastic detection device and method based on a pyrolysis-mass spectrometry technology. The microplastic detection device based on a pyrolysis-mass spectrometry technology provided by the present invention is substantially a sealed gas path device system formed connected via pipelines. The device includes a working gas source, a pyrolysis device, a filter and a mass spectrometer which are connected in sequence. After a microplastic sample is placed into the pyrolysis device, the microplastic sample is decomposed in the pyrolysis device, and pyrolysis products from the microplastic sample driven by a carrier gas of the working gas source enter the mass spectrometer for detection and analysis after being filtered by the filter. Furthermore, the present invention provides a microplastic detection method based on a pyrolysis-mass spectrometry. The present invention is widely applied to the field of a microplastic detection technology.