Patents by Inventor Jie Ku

Jie Ku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for early sacubitril intermediates
    Patent number: 10774036
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 15, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Tobias Kapferer, Hongyong Kim, Jie Ku, Kurt Laumen, Yunzhong Li, Wei Peng, Thomas Ruch, Thierry Schlama, Yao Yang
  • NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES
    Publication number: 20190359554
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 28, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER, Hongyong KIM, Jie KU, Kurt LAUMEN, Yunzhong LI, Wei PENG, Thomas RUCH, Thierry SCHLAMA, Yao YANG
  • Intermediates of neutral endopeptidase inhibitors and preparation method thereof
    Patent number: 9278908
    Abstract: The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: March 8, 2016
    Assignee: Novartis AG
    Inventors: David Hook, Jianguang Zhou, Yunzhong Li, Jie Ku
  • INTERMEDIATES OF NEUTRAL ENDOPEPTIDASE INHIBITORS AND PREPARATION METHOD THEREOF
    Publication number: 20150274642
    Abstract: The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Application
    Filed: June 15, 2015
    Publication date: October 1, 2015
    Inventors: David Hook, Jianguang Zhou, Yunzhong LI, Jie Ku
  • Intermediates of neutral endopeptidase inhibitors and preparation method thereof
    Patent number: 9067883
    Abstract: The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: June 30, 2015
    Assignee: Novartis AG
    Inventors: David Hook, Jianguang Zhou, Yunzhong Li, Jie Ku