Abstract: The present invention relates to a series of 2,6-dioxaspiro [4,5] decane derivatives and applications thereof in preparation of opiate receptor ? agonist related drugs; and in particular relates to the derivative compounds shown in formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

Abstract: The present disclosure relates to audio data processing methods and devices. One example method includes obtaining a first audio data and a second audio data, converting the first audio data into a first channel of audio data and converting the second audio data into a second channel of audio data, and at least one of outputting the first channel of audio data to a first audio output device or outputting the second channel of audio data to a second audio output device.

Abstract: The present invention discloses a display driver board with multiple TYPE-C full-function interfaces, including a first TYPE-C interface and a second TYPE-C interface, where the two TYPE-C interfaces are connected to a first connection device, a second connection device, a PD power control circuit, a protocol chip, a display signal processing circuit, and a USB HUB chip, respectively; the PD power control circuit is connected to a system power supply and the protocol chip; and the protocol chip is connected to forward/reverse insertion control signal ends of the first and second SWITCH chips, respectively.

Abstract: An apparatus and method for determining a volume stability of well cement including a reaction kettle, a radial contraction, an expansion ring, a heater, a pressurizer, and a volume change parameter tester. The radial contraction and expansion ring include a first casing and a second casing, the first casing is a casing made of elastic material, the second casing is a steel casing, and the first casing sheathes the second casing. The heater and the pressurizer are used to provide a preset temperature and a preset pressure respectively and the volume change parameter tester is used to detect a radial volume change parameter of the well cement. The apparatus is provided with the radial contraction and expansion ring to acquire the radial volume change parameter of the well cement, and comprehensively evaluates the volume stability of the well cement using the radial volume change parameter of the well cement.

Abstract: Disclosed in the present invention are an IRAK4 inhibitor, and an application thereof in preparation of a drug for treating IRAK4-related diseases. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure discloses a trench MOSFET and a method of manufacturing trench MOSFET. The trench MOSFET includes a substrate, an epitaxial layer, a plurality of trenches, and body region; the substrate has a first conductivity type; the epitaxial layer has the first conductivity type; the plurality of trenches are formed in the epitaxial layer, and at least two of the plurality of trenches are communicated with each other a gate structure is provided in the trench; the body region has a second conductivity type and has a second conductivity type and is disposed among the plurality of trenches.

Abstract: A method and apparatus for constructing a 3D scene model are provided. The method includes: acquiring a first point cloud corresponding to a current target scene (S101); determining a first partial point cloud corresponding to a dynamic object from the first point cloud (S102); constructing a foreground 3D model based on the first partial point cloud (S103); and superimposing the foreground 3D model with a background 3D model to obtain a current 3D scene model (S104). As can be seen, it is not necessary to fuse each pixel acquired by each depth camera. Instead, the dynamic object is determined in the point cloud acquired by the depth camera. Only the foreground 3D model corresponding to the dynamic object is superimposed with the background 3D model corresponding to the static objects obtained in advance. This reduces the amount of computation to build a 3D scene model.

Abstract: The present specification provides a method for, including: collecting information about respective geographic positions of users using shared vehicles; determining, for each one of the respective geographic positions, popularity indexes of the shared vehicles in an area corresponding to the geographic position; determining, for each one of the respective geographic positions and based on the popularity indexes, a popularity score of the shared vehicles within the area corresponding to the geographic position; mapping the popularity scores to corresponding color values; and generating a presentation of the areas with visual attributes representing the popularity scores of the shared vehicles within the areas, wherein generating the visual presentation comprises rendering the presentation in accordance with the color values.

Abstract: The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

Abstract: A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: An apparatus and method to evaluate light-weight cement (LWC) bond conditions behind the casing in a downhole environment of a wellbore. The apparatus includes a logging (CBL) instrument that can detect aberrations in the LWC behind the casing based on variations in the transducer impedance measurements without using pad. The CBL instrument includes a transducer matrix, a signal acquisition controller, a data processing module, and a communication unit.

Abstract: A touch circuit includes a touch circuit, a first energy storage circuit, a second energy storage circuit and a resetting circuit. A first end of the first energy storage circuit is connected to a control end of the touch circuit, and a second end thereof is connected to a first voltage input end. A first end of the second energy storage circuit is connected to a first conductive line, and a second end thereof is connected to the control end of the touch circuit. A first end of the touch circuit is connected to the first conductive line, and a second end thereof is connected to a third conductive line. A control end of the resetting circuit is connected to a second conductive line, a first end thereof is connected to the third conductive line, and a second end thereof is connected to a second voltage input end.

Abstract: An auxiliary device for photo-taking and video-taking and a multifunctional support bracket. A spherical base, arranged on an upper part of the main body, includes a spherical concave shape with an upward-facing opening and provides a cooperation member for being fixedly connected to a spherical-bottomed ball head. A flat-bottomed platform, with one side face detachably fixed to the opening of the spherical base through the cooperation member, has the other side face provided with a connection member for being fixedly connected to a flat-bottomed ball head. A flat-bottomed ball head, fixedly connectable to the connection member of the flat-bottomed platform. A spherical-bottomed ball head, for being fixed in the spherical base after the flat-bottomed platform is removed, and detachably fixedly connected to the cooperation member of the spherical base. The multifunctional support bracket and the assembly thereof may be applied to both flat-bottomed ball head and spherical-bottomed ball head.

Abstract: A computer room heat-pipe air conditioning system with an emergency cooling control method. The system comprises a phase-change energy storage module, a phase-change material packaging body, a condenser housing, a condenser, a cold releasing pump, evaporators, evaporation fans, four three-way valves, a cooling unit, standby power generators and storage batteries. The three-way valves are opened and closed based on a preset heat-pipe cooling criteria in combination with phase-change energy storage technology.

Abstract: Disclosed are a thieno[2,3-c]pyridazin-4(1H)-one derivative as an ACC1 or ACC2 inhibitor and an application thereof in preparing a drug as an ACC1 or ACC2 inhibitor. In particular, disclosed is a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Abstract: The present disclosure discloses an M-ary DCSK method based on chaotic shape-forming filtering. The method includes the following steps: at S1, parameters of a communication system are set; at S2, HP information and LP information to be sent in each time slot are prepared; at S3, the information to be sent is modulated; at S4, a chaotic carrier is generated through a chaotic shape-forming filter; at S5, a transmitted signal is prepared; at S6, down-carrier frequency and matched filter is performed to a received signal; at S7, the sampling of a maximum SNR point is performed to an output signal of a matched filter; at S8, the decision of high priority information bits is resumed; and at S9, the decision of low priority information bits is resumed.