Patents by Inventor Jie Lou

Jie Lou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115713
    Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.
    Type: Application
    Filed: July 21, 2021
    Publication date: April 11, 2024
    Inventors: Gaoquan LI, Nian LIU, Yongchen PENG, Xiafan ZENG, Gang MEI, Sheng GUAN, Yang GAO, Shuai YANG, Yifeng YIN, Jie LOU, Huiyu CHEN, Kun QIAN, Yusong WEI, Qian ZHANG, Dajun LI, Xiaoling DING, Xiangwei YANG, Liqun HUANG, Xi LIU, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Tao TU
  • Patent number: 11813334
    Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: November 14, 2023
    Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.
    Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Diedie Li, Chengzhi Gao, Yue Liu, Xiaoling Ding, Yusong Wei, Xiangwei Yang, Yongchen Peng, Jia Gao, Qiang Luo, Yanxia Heng, Mei Liu, Yuyang Yi, Xiafan Zeng, Tao Tu, Xiao Tang, Xi Liu, Jianhuan Li, Zhaojie Wang, Bin Wang, Jinping Wan, Mingyang Hou, Jiao Liu, Huiyu Chen, Jie Lou, Yue Yang, Yuanqiang Wang
  • Publication number: 20230348671
    Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 2, 2023
    Inventors: Gaoquan LI, Nian LIU, Xiafan ZENG, Yongchen PENG, Gang MEI, Shuai YANG, Yang GAO, Sheng GUAN, Yifeng YIN, Huiyu CHEN, Jie LOU, Kun QIAN, Xiangwei YANG, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Qian ZHANG, Dajun LI, Yusong WEI, Xiaoling DING, Xi LIU, Liqun HUANG, Tao TU
  • Patent number: 11793881
    Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: October 24, 2023
    Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.
    Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Yusong Wei, Yongchen Peng, Xiangwei Yang, Xiafan Zeng, Gang Mei, Diedie Li, Chengzhi Gao, Xiaoling Ding, Yue Liu, Jia Gao, Yuyang Yi, Yanxia Heng, Xi Liu, Tao Tu, Kai Wang, Liwei Liu, Mei Liu, Qiang Luo, Xiao Tang, Jie Lou, Huiyu Chen, Yue Yang, Yuanqiang Wang
  • Publication number: 20230194256
    Abstract: A lens assembly for display includes a display, a lens assembly, and a prism assembly. The display emits a first light beam. The lens assembly includes a first, second, and third lenses. The prism assembly includes a first, second prisms, and an optical multilayer film, wherein the first prism includes a first, second, and third surfaces and the second prism includes a fourth, fifth, sixth, seventh, and eighth surfaces. The lens assembly for display satisfies at least one of following conditions: 0.60?Din/TTL?0.75; 0.28?Din/f123?0.35; 4.56 mm?Din?5.02 mm; wherein Din is an effective optical diameter of the light incident surface, TTL is an interval from the light incident surface to the light emitting surface along the optical axis, and f123 is an effective focal length of a combination of the first lens, the second lens, and the third lens.
    Type: Application
    Filed: February 8, 2023
    Publication date: June 22, 2023
    Inventors: Fang-Li Ma, Yue-Ye Chen, Bin Liu, Jun-Wei Che, We-Jie Lou, Hua-Tang Liu
  • Publication number: 20230101564
    Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.
    Type: Application
    Filed: March 11, 2020
    Publication date: March 30, 2023
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Diedie LI, Chengzhi GAO, Yue LIU, Xiaoling DING, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Bin WANG, Jinping WAN, Mingyang HOU, Jiao LIU, Huiyu CHEN, Jie LOU, Yue YANG, Yuanqiang WANG
  • Publication number: 20230088403
    Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 23, 2023
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Yusong WEI, Yongchen PENG, Xiangwei YANG, Xiafan ZENG, Gang MEI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Jia GAO, Yuyang Yi, Yanxia HENG, Xi LIU, Tao TU, Kai WANG, Liwei LIU, Mei LIU, Qiang LUO, Xiao TANG, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Patent number: 11604064
    Abstract: A lens assembly for display includes a display, a lens assembly, and a prism assembly. The display emits a first light beam. The prism assembly includes a first, second prisms, and an optical multilayer film, wherein the first prism includes a first, second, and third surfaces; the second prism includes a fourth, fifth, sixth, seventh, and eighth surfaces; and the optical multilayer film is disposed between the third and fifth surfaces. A second light beam enters the first prism through the first surface and exits by the second surface. The first light beam exits the lens assembly and enters the second prism through the eighth surface, and exits the first prism by the second surface. The lens assembly and the prism assembly satisfy: 0.80%?E1/E0?0.95%; wherein E0 is an energy of the first light beam emitted from the display and E1 is an energy of the first light beam passes through the lens assembly.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: March 14, 2023
    Assignees: SINTAI OPTICAL (SHENZHEN) CO., LTD., ASIA OPTICAL CO., INC.
    Inventors: Fang-Li Ma, Yue-Ye Chen, Bin Liu, Jun-Wei Che, We-Jie Lou, Hua-Tang Liu
  • Publication number: 20230073036
    Abstract: The disclosure relates to the technical field of medicine, specifically to a polyethylene glycol conjugated drug, a preparation method therefor and use thereof, and relates in particular to a polyethylene glycol conjugated drug represented by formula (I) or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.
    Type: Application
    Filed: March 11, 2020
    Publication date: March 9, 2023
    Inventors: Gaoquan LI, Qian ZHANG, Dajun LI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Jinping WAN, Mingyang HOU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Publication number: 20220105189
    Abstract: The disclosure relates to the technical field of medicine and in particular to a polyethylene glycol conjugated drug of formula I or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation and an intermediate of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.
    Type: Application
    Filed: June 3, 2019
    Publication date: April 7, 2022
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Xiaoling DING, Diedie LI, Lei HUANG, Jinping WAN, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jiao LIU, Jianhuan LI, Qiang LUO, Xi LIU, Bin WANG, Hui GONG, Yu CHEN, Yunjie JIANG, Zhongquan LIU, Kun XU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Publication number: 20200340810
    Abstract: A lens assembly for display includes a display, a lens assembly, and a prism assembly. The display emits a first light beam. The prism assembly includes a first, second prisms, and an optical multilayer film, wherein the first prism includes a first, second, and third surfaces; the second prism includes a fourth, fifth, sixth, seventh, and eighth surfaces; and the optical multilayer film is disposed between the third and fifth surfaces. A second light beam enters the first prism through the first surface and exits by the second surface. The first light beam exits the lens assembly and enters the second prism through the eighth surface, and exits the first prism by the second surface. The lens assembly and the prism assembly satisfy: 0.80%?E1/E0?0.95%; wherein E0 is an energy of the first light beam emitted from the display and E1 is an energy of the first light beam passes through the lens assembly.
    Type: Application
    Filed: March 16, 2020
    Publication date: October 29, 2020
    Inventors: Fang-Li Ma, Yue-Ye Chen, Bin Liu, Jun-Wei Che, We-Jie Lou, Hua-Tang Liu
  • Patent number: 10756509
    Abstract: This invention provides an accurate current mirror circuit in a low voltage headroom applied to common-anode laser drivers, including a reference current detection unit, a tail current source unit, and a control unit. The reference current detection unit generates a bias voltage and a reference voltage according to a reference current from the reference current source; the tail current source unit receives the bias voltage and generate a mirror current accordingly; the control unit receives the reference voltage and an output voltage corresponding to the mirror current and carry out a feedback regulation to the bias voltage accordingly. In this invention, the reference voltage and the output voltage are locked at same level, and then the bias voltage is mirrored to generate the mirror current outputted to the laser, thus avoiding the problem of inaccurate current output caused by the offset of the control unit in the low voltage headroom.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: August 25, 2020
    Assignee: AMPLIPHY TECHNOLOGIES LIMITED
    Inventors: Hehong Zou, Tianlin Cao, Jie Lou, Zhuoyuan Li
  • Patent number: 10712761
    Abstract: This invention provides a multi-bit digitally controlled accurate current source circuit including a reference current detection unit, a voltage buffer unit, a digital logic control unit, a switch array unit, and a current source array unit. The reference current detection unit generates a first bias voltage according to a reference current; the voltage buffer unit receives the first bias voltage, and generate a buffer voltage accordingly; the digital logic control unit receives the buffer voltage, and generate a digital control signal accordingly; the switch array unit receives the digital control signal, and generate on-off signals accordingly; and the current source array unit receives and responds to the on-off signals so as to control turn-on and turn-off of the current sources in the current source array unit. In this invention, by adding only one voltage buffer, a cascode current source if formed, and an area saving accurate current source is realized.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: July 14, 2020
    Assignee: AMPLIPHY TECHNOLOGIES LIMITED
    Inventors: Tianlin Cao, Yichao He, Jie Lou, Qingping Li, Zhuoyuan Li
  • Publication number: 20200089265
    Abstract: This invention provides a multi-bit digitally controlled accurate current source circuit including a reference current detection unit, a voltage buffer unit, a digital logic control unit, a switch array unit, and a current source array unit. The reference current detection unit generates a first bias voltage according to a reference current; the voltage buffer unit receives the first bias voltage, and generate a buffer voltage accordingly; the digital logic control unit receives the buffer voltage, and generate a digital control signal accordingly; the switch array unit receives the digital control signal, and generate on-off signals accordingly; and the current source array unit receives and responds to the on-off signals so as to control turn-on and turn-off of the current sources in the current source array unit. In this invention, by adding only one voltage buffer, a cascode current source if formed, and an area saving accurate current source is realized.
    Type: Application
    Filed: January 14, 2019
    Publication date: March 19, 2020
    Applicant: AmpliPHY Technologies Limited
    Inventors: Tianlin CAO, Yichao He, Jie Lou, Qingping Li, Zhuoyuan Li
  • Publication number: 20200091678
    Abstract: This invention provides an accurate current mirror circuit in a low voltage headroom applied to common-anode laser drivers, including a reference current detection unit, a tail current source unit, and a control unit. The reference current detection unit generates a bias voltage and a reference voltage according to a reference current from the reference current source; the tail current source unit receives the bias voltage and generate a mirror current accordingly; the control unit receives the reference voltage and an output voltage corresponding to the mirror current and carry out a feedback regulation to the bias voltage accordingly. In this invention, the reference voltage and the output voltage are locked at same level, and then the bias voltage is mirrored to generate the mirror current outputted to the laser, thus avoiding the problem of inaccurate current output caused by the offset of the control unit in the low voltage headroom.
    Type: Application
    Filed: January 14, 2019
    Publication date: March 19, 2020
    Applicant: AmpliPHY Technologies Limited
    Inventors: Hehong ZOU, Tianlin CAO, Jie LOU, Zhuoyuan LI