Abstract: Disclosed are novel compositions and methods of using the same for the treatment of Erythropoiefic protoporphyria (EPP) and X-linked protoporphyria (XLP). Disclosed are methods and compositions related to treating Erythropoietic protoporphyria and X-linked protoporphyria. Also described are therapeutic agents that can inhibit ABCG2. For example, provided herein are therapeutic agents defined by Formula I.

Abstract: A novel distributed graph database is provided that is designed for efficient graph data storage and processing on modern computing architectures. In particular a single node graph database and a runtime & communication layer allows for composing a distributed graph database from multiple single node instances.

Abstract: A novel distributed graph database is provided that is designed for efficient graph data storage and processing on modern computing architectures. In particular a single node graph database and a runtime & communication layer allows for composing a distributed graph database from multiple single node instances.

Abstract: A novel distributed graph database is provided that is designed for efficient graph data storage and processing on modern computing architectures. In particular a single node graph database and a runtime & communication layer allows for composing a distributed graph database from multiple single node instances.

Abstract: A solution for capacity planning includes: for each of a plurality of fulfillment centers (FCs), receiving an inventory allocation; receiving a demand forecast and delivery time information for customer orders; performing a simulation comprising: partitioning a simulation period into multiple simulation stages; for each simulation stage: assigning portions of the demand forecast to a demand pool for one of the FCs; for each FC, determining a backlog, based at least on the demand pool for the FC and a simulation stage fulfillment capacity for the FC; and transferring each existing backlog to a subsequent simulation stage or an alternate FC; and based at least on the simulation, generating at least one planning control logic action, for example, adjusting delivery time options available on an e-commerce node, identifying a change in staffing levels at one or more FCs, adjusting inventory allocation for at least one FC, or another action.

Abstract: Provided are a method and device determining a driving route of a sorting robot. The method comprises: weighting and scanning on an import platform (310) in response to a sorting robot (320), and determining a destination of the sorting robot on a sorting map; determining, according to the destination, a target package drop (330) on the sorting map; identifying two dumping points on a route which is perpendicular to an import direction of the import platform among dumping points of the target package drop; respectively calculating the costs of routes from the import platform to the two dumping points; determining the dumping point corresponding to the smaller cost of route to be the target dumping point on the sorting map; determining a preferred package drop route from predetermined package drop routes to be selected from the import platform to the target dumping point; and sending a package drop task including the preferred package drop route to the sorting robot.

Abstract: The present invention is directed to an improved purification process using additive and activated carbon for purifying resorbable polymers suitable for industrial manufacturing. The metal catalyst concentration in the purified resorbable polymers of this invention is preferably less than 1 ppm. The method can be used to obtain high molecular weight polymers that are substantially metal free.

Abstract: A method of making a synthetic hectorite-type mineral is described, along with its resulting physical and rheological properties. The synthetic hectorite-type mineral is a 2:1 phyllosilicate essentially free of aluminum, and having a trioctahedral structure with Mg2+ and Li+ occupying octahedral sites. As a hydrogel, the synthetic hectorite-type mineral has a swell index of greater than 55 mL, and a yield point of greater than 290 Pa. The method of making uses a MgO/MgCO3 buffer system, with heating for about 2 hours at temperatures of no higher than 300° C. and pressures of no higher than 600 psi.

Abstract: A new multifunctional biomass suspension deflagration test-bed is provided, which includes a closed combustion chamber. An integrated temperature and pressure sensor is arranged in the combustion chamber, and a high-speed camera and a laser concentration-measuring instrument are arranged outside the combustion chamber, which can monitor suspension deflagration. A bottom of the combustion chamber is provided with a hollow mushroom-shaped dispersion nozzle with a tray. A nozzle body is provided with a gas main-flow channel at a center thereof and gas deflected-flow channels arranged around the gas main-flow channel. A mushroom-shaped baffle plate is arranged above the nozzle body. The gas main-flow channel extends upward to the mushroom-shaped baffle plate. A vent hole is formed in a portion of the mushroom-shaped baffle plate which is corresponding to the gas main-flow channel. Each gas deflected-flow channel is inclined outward from bottom to top and directed to the mushroom-shaped baffle plate.

Abstract: The present disclosure relates to systems and methods for determining a motion of an object during imaging. The systems and methods may cause a light emission device to project a structured light onto the object, and cause a light reception device to detect light resulting from the structured light as projected onto the object and generate a plurality of measured images of the structured light based on the detected light. The systems and methods may further determine the motion of the object based on the plurality of measured images of the structured light and a reference image of the structured light.

Abstract: A system includes a user model module that generates a plurality of topic-specific user knowledge models for each user of a plurality of users, each topic-specific user knowledge model representing a level of knowledge possessed by a respective user on a single topic from a set of globally defined topics shared among the plurality of users, a expertise model building module that generates a plurality of topic-specific expert knowledge models, each topic-specific expert knowledge model representing an aggregate level of knowledge possessed by a plurality of expert users on a single topic from a set of globally defined topics shared among the plurality of users, and a processor of a computer that executes instructions for comparing the topic-specific user knowledge model of the first user with the topic-specific expert knowledge model for a respective topic to determine a distance between a user knowledge level and an aggregate expert knowledge level for the topic.

Abstract: A method includes generating, as executed by a processor on a computer, a plurality of topic-specific user knowledge models for each user of a plurality of users, each topic-specific user knowledge model representing a level of knowledge possessed by a respective user on a single topic from a set of globally defined topics shared among the plurality of users, generating a plurality of topic-specific expert knowledge models, each topic-specific expert knowledge model representing an aggregate level of knowledge possessed by a plurality of expert users on a single topic from a set of globally defined topics shared among the plurality of users, comparing the topic-specific user knowledge model of the first user with the topic-specific expert knowledge model for a respective topic to determine a distance between a user knowledge level and an aggregate expert knowledge level for the topic.

Abstract: The present disclosure discloses a walking power control system for wolfberry picking, including a frame, a turntable, rotating rods, first gears, second gear, gear racks, supporting rods, hydraulic motors, a front traveling wheel, a left traveling wheel and a right traveling wheel. In the present disclosure, hydraulic motors rotate to drives three traveling wheels to rotate, thereby driving the frame to move, when it is necessary to turn, a turntable is rotated, the turntable rotates to drive two first gears to rotate, and the two first gears rotate to drive the supporting rods to rotate, thereby driving the left traveling wheel and the right traveling wheel to rotate, so that the traveling direction of the frame is changed. The picking speed of wolfberries is greatly improved, thereby improving the working efficiency and saving a lot of human resources.

Abstract: A 99mTc-labeled isonitrile-containing glucose derivative having the general formula [99mTc-(CNDG)6]+, preparation method and use thereof is disclosed herein. The derivative is centered on 99mTc+, and the carbon atom of the isonitrile in CNDG coordinates with 99mTc(I) to form a hexacoordinated complex [99mTc-(CNDG)6]+. The [99mTc-(CNDG)6]+ derivative was obtained by the synthesis of the ligand CNDG and the preparation of the lyophilized CNDG kit. The derivative of the present invention this disclosure has good stability, simple preparation, high uptake and good retention at a tumor site, and high tumor/non-target ratio, and it is a novel 99mTc-labeled isonitrile-containing glucose derivative with excellent performance for tumor imaging. The derivative of the present invention this disclosure is advantageous for popularization and application.

Abstract: A method of manufacturing hybrid cable applicable in oil wells provides an FIMT, a conductor layer formed by continuous laser welding and cylindrically covered the outer surface of the FIMT, the outer cylindrical surface of the conductor layer being covered with a high temperature resistant insulating layer by a continuous extrusion method or by wrapped helically with insulating tapes around the outer surface of the conductor layer and the external steel tube cylindrically covered the outer surface of the insulating layer. The conductor layer is coaxial with the FIMT, the inner space of the hybrid cable to accommodating excess length of the optical fiber to allow for thermal expansions and tensile stress on the optical cable. The thickness of the insulating layer cylindrically covering the outer surface of the conductor layer is able to be increased, improving the insulating property.

Abstract: A method of producing a polymer foam may include providing a polymer composition, introducing an alkaline earth metal silicate into the polymer composition, and foaming the polymer composition using a gas to form a polymer foam. A method of producing a polymer-matrix may include providing a polymer composition, nucleating the polymer composition with an alkaline earth metal silicate, and using a blowing agent to form a polymer foam from the polymer composition. The alkaline earth metal silicate may facilitate nucleation of the cells in the polymer foam. A polymer foam composition may include a polymer-based foam matrix and an alkaline earth metal silicate within a cell of the polymer-based foam matrix.

Abstract: A system and method are provided for reconstructing 3-D point cloud. A light source generates light that is received by a polarization field generator, which generates a polarization field that illuminates the target object being imaged such that each outgoing ray has a unique polarization state. A camera captures images of the illuminated target object and the captured images are received by a processor that: (1) performs a polarization field decoding algorithm that decodes the polarization field to obtain a set of incident rays; (2) performs a camera ray decoding algorithm to obtain a set of camera rays; (3) performs a ray-ray intersection algorithm that determines intersection points where the incident rays and the camera rays intersect; and (4) performs a 3-D reconstruction algorithm that uses the set of incident rays, the set of camera rays and the intersection points to reconstruct a 3-D point cloud of the target object.