Abstract: A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.

Abstract: The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

Abstract: A nozzle tip assembly and method characterized by the use of a retention device including at least one tab that cooperates with a ledge for coupling a nozzle shroud to a nozzle adaptor. The retention device can be used as a secondary retention feature to prevent nozzle separation and/or to enable the fuel injector to be repaired without having to replace the entire assembly. The latter advantage is of particular benefit when there is damage during assembly or when the nozzle tip assembly is being overhauled.

Abstract: The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

Abstract: We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DR?1*0101-restricted CD4+ T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4+ T cells are potential targets for cancer immunotherapy.

Abstract: A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.

Abstract: A device may provide for display equipment associated with a channel path of a video network, receive selection of one of the equipment, provide for display the selected equipment, receive selection of a port of the selected equipment, and provide for display other equipment of the video network connected to the selected port.

Abstract: A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.

Abstract: The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.

Abstract: The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

Abstract: We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DR?1*0101-restricted CD4+ T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4+ T cells are potential targets for cancer immunotherapy.

Abstract: A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.

Abstract: A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.

Abstract: An approach is provided for network resource growth management. Utilization of a network resource that is hierarchically associated with one or more other network resources is determined. If the utilization exceeds a first predetermined threshold, a growth notification is triggered. The growth notification specifies additional network resources required to modify the utilization of the network resource according to a second predetermined threshold.

Abstract: A nozzle tip assembly and method characterized by the use of a retention device including at least one tab that cooperates with a ledge for coupling a nozzle shroud to a nozzle adaptor. The retention device can be used as a secondary retention feature to prevent nozzle separation and/or to enable the fuel injector to be repaired without having to replace the entire assembly. The latter advantage is of particular benefit when there is damage during assembly or when the nozzle tip assembly is being overhauled.

Abstract: A device may provide for display equipment associated with a channel path of a video network, receive selection of one of the equipment, provide for display the selected equipment, receive selection of a port of the selected equipment, and provide for display other equipment of the video network connected to the selected port.

Abstract: A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.

Abstract: A fuel injector for gas turbine engines includes an inlet fitting, a housing stem, and a spray nozzle. A pair of fuel passages in the stem deliver fuel in a primary (continuous) flow and a secondary (non-continuous or reduced) flow to primary and secondary discharge orifices in the nozzle. The fuel passages are defined by inner and outer concentric conduits, with the primary flow directed through the inner conduit, and the secondary flow directed through the outer conduit. Fins are provided unitary with the inner conduit along the length of the housing stem, and are fixed at their radial outer ends to the outer conduit. The fins provide structural support and thermally connect the inner and outer conduits. During low power operation, the fins transfer heat energy between the outer conduit to the inner conduit to cool the outer conduit and thermally protect the fuel in the secondary fuel passage.

Abstract: A fuel injector for a gas turbine engine has an inlet fitting, a fuel nozzle, and a housing stem with a pair of fuel conduits fluidly interconnecting the nozzle and fitting. The fuel nozzle includes an annular secondary fuel passageway directing fuel from one fuel conduit to an annular discharge orifice at a discharge end of the nozzle. The secondary fuel passageway is defined between an outer, annular fuel conduit portion and a primary adapter. The primary adapter has an outer surface with a distinct, radially-outwardly-projecting annular shoulder to restrict flow through the secondary passageway and provide substantially uniform distribution of flow through the passageway downstream of the shoulder, for improved combustion and flame stability.