Abstract: A system and a method for assessing the ovarian reserve function of a subject. The system for assessing a subject's ovarian reserve function comprises: a data acquisition module configured to acquire data of the subject's age, anti-Müllerian hormone (AMH) level, follicle stimulating hormone (FSH) level, and antral follicle count (AFC); and an ovarian reserve function calculation module configured to calculate the above-mentioned information acquired in the data acquisition module, so as to work out the subject's probability of poor ovarian response (p). Further, the population is divided into four groups according to the interaction relationship between the predicted probability of poor ovarian response and the dose of ovulation stimulants, so as to divide the population with similar ovarian responses into one group.

Abstract: Disclosed are a strain of Lactobacillus helveticus capable of removing multiple heavy metals and an application thereof in milk powder, where the strain is Lactobacillus helveticus KD-3, which is deposited in the China Center for Type Culture Collection on Apr. 6, 2023, with a deposit number of CCTCC NO: M2023479. The Lactobacillus helveticus KD-3 has a cadmium resistant gene czcD, a chromium resistant gene chrA and a lead resistant gene pbrT, and is capable of tolerating single and compound heavy metals (cadmium, chromium and lead). The Lactobacillus helveticus KD-3 of the present disclosure is used to prepare lyophilized bacterial powder.

Abstract: A chip pad surface leveling device includes a signal control module, a glass carrying module and a temperature control module. The glass carrying module is configured to move a leveling glass substrate to contact a plurality of first convex pillar structures of a first chip or a plurality of second convex pillar structures of a second chip. The temperature control module is configured to apply a predetermined temperature to the first convex pillar structures or the second convex pillar structures, and the glass carrying module is configured to apply a predetermined pressure to the first convex pillar structures or the second convex pillar structures through the leveling glass substrate, thereby making a surface roughness of a bonding pad end of each first convex pillar structure or a surface roughness of a bonding pad end of each second convex pillar structure is not greater than 1 ?m.

Abstract: A heterogeneous chip stacking method includes providing a first chip, in which the first chip has a plurality of first convex pillar structures, and each first convex pillar structure has a first bonding pad portion; providing a second chip different from the first chip, in which the second chip has a plurality of second convex pillar structures, and each second convex pillar structures having a second bonding pad portion; placing the first chip on the second chip, in which the first bonding pad portions of the first convex pillar structures and the second bonding pad portions of the second convex pillar structures are in direct contact with each other respectively; and then applying at least one of a predetermined pressure, a predetermined temperature, and a predetermined ultrasonic frequency to tightly couple the first bonding pad portions and the second bonding pad portions with each other respectively.

Abstract: The present disclosure provides a method and an apparatus of denoising a mechanical vibration signal, a medium, and a device. The method includes: processing a real-time acquired vibration signal using a generalized variational mode decomposition algorithm GVMD to acquire multiple intrinsic mode function sub signals; clustering the multiple intrinsic mode function sub signals, and dividing the multiple intrinsic mode function sub signals into several categories; and assigning different Gaussian scale coefficients to different categories of intrinsic mode function sub signals, using a non-local means algorithm NLM to filter each intrinsic mode function sub signal, respectively, and summing them, so as to acquire a denoised vibration signal.

Abstract: A heterogeneous chip stacking device includes a substrate carrying structure, a position-limiting substrate structure, a first cover structure, a second cover structure and a chip carrying structure. The position-limiting substrate structure is detachably disposed on the substrate carrying structure. The first cover structure is detachably disposed above the position-limiting substrate structure. The second cover structure is detachably disposed on the first cover structure. The chip carrying structure is movably disposed above the substrate carrying structure. The position-limiting substrate structure has a plurality of position-limiting grooves for respectively accommodating a plurality of first chips. The first cover structure is disposed on the first chips to press the first chips, and the first cover structure has a plurality of first openings configured to respectively accommodate a plurality of second chips.

Abstract: A heterogeneous chip stacking structure includes a first chip and a second chip. The first chip has a plurality of first convex pillar structures gradually formed outward from the first chip within a first predetermined time, and each of the first convex pillar structures has a first bonding pad portion. The second chip has a plurality of second convex pillar structures gradually formed outward from the second chip within a second predetermined time, and each of the second convex pillar structures has a second bonding pad portion. The first chip is configured to be disposed on the second chip, and the first bonding pad portions of the first convex pillar structures of the first chip and the second bonding pad portions of the second convex pillar structures of the second chip are in direct contact with each other and tightly coupled with each other, respectively.

Abstract: Disclosed are a strain of Lactobacillus helveticus capable of removing multiple heavy metals and an application thereof in milk powder, where the strain is Lactobacillus helveticus KD-3, which is deposited in the China Center for Type Culture Collection on Apr. 6, 2023, with a deposit number of CCTCC NO: M2023479. The Lactobacillus helveticus KD-3 has a cadmium resistant gene czcD, a chromium resistant gene chrA and a lead resistant gene pbrT, and is capable of tolerating single and compound heavy metals (cadmium, chromium and lead). The Lactobacillus helveticus KD-3 of the present disclosure is used to prepare lyophilized bacterial powder.

Abstract: A portable electronic device, and an image-capturing device and an assembly method thereof are provided. The image-capturing device includes a carrier substrate, an image sensing chip, a filter element and a lens assembly. The carrier substrate has a through opening and a recessed space. The image sensing chip is disposed on the bottom side of the carrier substrate. The filter element is disposed in the recessed space of the carrier substrate, so that all or a part of the filter element is accommodated in the through opening. When at least one microparticle with a maximum particle size between 5 ?m and 25 ?m is located on the filter element, a shortest distance between the filter element and the image sensing chip is between 30 ?m and 200 ?m, so that the image sensing chip cannot capture a light spot generated due to blocking of the microparticle.

Abstract: Disclosed in the present invention is a non-invasive detection method for screening for a well-developed blastocyst. A DNA methylation profile of a few of trophectoderm cells in a blastocyst is detected, and the average methylation level and the methylation pattern of embryos identified as having a good morphology in Gardner morphological blastocyst grading process are used as the standard for screening for well-developed blastocysts. The nearer the methylation level of the trophectoderm cells of the blastocyst to be tested approaches the methylation level or state of the good embryo, the better the embryo development is and the higher the suitability for being implanted into a maternal subject is. Furthermore, results of methylation sequencing may be analyzed to determine whether a chromosome is abnormal, so as to directly exclude chromosome-abnormal embryos.

Abstract: A DNA methylation profile of a few of trophectoderm cells in a blastocyst is detected, and the average methylation 5 level and the methylation pattern of embryos identified as having a good morphology in Gardner morphological blastocyst grading process are used as the standard for screening for well-developed blastocysts. The nearer the methylation level of the trophectoderm cells of the blastocyst to be tested approaches the methylation level or state of the good embryo, the better the embryo development is and the higher the 10 suitability for being implanted into a maternal subject is.

Abstract: The present invention relates to a method for producing an at least partially coated object and to an at least partially coated object obtained by the method. The method comprises bringing the object completely or partly into contact with a treating agent; leaving the object at 10° C.-30° C. and 100 mbar-800 mbar for 3-10 minutes; and heat-treating the object at a temperature of 70° C.-90° C.

Abstract: A portable electronic device, and an image-capturing device and an assembly method thereof are provided. The image-capturing device includes a carrier substrate, an image sensing chip, a filter element and a lens assembly. The carrier substrate has a through opening and a recessed space. The image sensing chip is disposed on the bottom side of the carrier substrate. The filter element is disposed in the recessed space of the carrier substrate, so that all or a part of the filter element is accommodated in the through opening. When at least one microparticle with a maximum particle size between 5 ?m and 25 ?m is located on the filter element, a shortest distance between the filter element and the image sensing chip is between 30 ?m and 200 ?m, so that the image sensing chip cannot capture a light spot generated due to blocking of the microparticle.

Abstract: The disclosure relates to methods and systems incorporating physical modeling to identify the ultrafast laser/material interaction mechanisms and the impact of laser parameters, to optimize implementation of ultrafast laser-based processing for a given material. The process determines a laser fluence near the ablation threshold for a given material and given pulse duration. The repetition rate, scanning speed and scanning strategy are subsequently optimized to minimize heat accumulation, having an operable line scan overlap between 50% to 85% for achieving smooth ultrafast-laser polishing, while maintaining an optic-quality surface.

Abstract: A biomimetic ice growth inhibition material is prepared. by constructing a library for structures of compound molecules, with the compound molecules comprising a hydrophilic group and an ice-philic group, by evaluating the spreading performance of each compound molecule at an ice-water interface by adopting molecular dynamics simulation (MD simulation), and by screening the compound molecules with the desired affinities for ice and water. The present invention firstly provides the mechanism of the affinities of the ice growth inhibition material for ice and water, introduces MD simulation into the molecular structure design of the ice growth inhibition material, evaluates the affinities of the designed ice growth inhibition material for ice and water through MD simulation, predicts the ice growth inhibition performance of the ice growth inhibition material, and can realize the optimization of the structure.

Abstract: A thawing solution has 0.1-50 g of a biomimetic material for controlling ice, 0-1.0 mol L?1 of a water-soluble sugar, and balance of a buffer solution. The biomimetic material for controlling ice is a material for controlling ice having an ice-philic group and a hydrophilic group. The hydrophilic group is a functional group that can form a non-covalent interaction with water molecules, and the ice-philic group is a functional group that can form a non-covalent interaction with ice. Using the thawing solution and the thawing reagent prepared from the biomimetic material for controlling ice, which material has ice-philic and hydrophilic properties, the growth and recrystallization of ice crystals can be effectively controlled, and damage to cells or tissue caused by uncontrolled growth of the ice crystals during recovery can be significantly ameliorated.

Abstract: A cryopreservation solution contains 0.01-50.0 g of bionic ice control materials, 5.0-30 mL of polyols, 1-30 g of water-soluble sugar, and 0-30 mL of serum, and a buffer in every 100 mL of the cryopreservation solution. It does not contain DMSO. When being used for the cryopreservation of mouse oocytes and embryos, the solution may achieve the same or an even higher cell and tissue survival rate and functional expression stability as or than a commercial cryopreservation solution (containing 15% DMSO), and has high preservation efficiency. The cryopreservation solution without DMSO or serum reduces parasitic biological contaminants in the commercial cryopreservation solution containing serum currently used in clinical practice.

Abstract: A serum-free cryopreservation solution contains a biomimetic ice control material, a polyol, a water-soluble sugar, and a buffer solution margin. The bionic ice control material can be polyvinyl alcohol or an amino acid compound. The cryopreservation liquid of the present invention uses the bionic ice control material as the main component, does not contain serum, has low toxicity, and can achieve a cell survival rate that is the same as, or higher than, existing cryopreservation solutions.

Abstract: A system and a method for assessing the ovarian reserve function of a subject. The system for assessing a subject's ovarian reserve function comprises: a data acquisition module configured to acquire data of the subject's age, anti-Müllerian hormone (AMH) level, follicle stimulating hormone (FSH) level, and antral follicle count (AFC); and an ovarian reserve function calculation module configured to calculate the above-mentioned information acquired in the data acquisition module, so as to work out the subject's probability of poor ovarian response (p). Further, the population is divided into four groups according to the interaction relationship between the predicted probability of poor ovarian response and the dose of ovulation stimulants, so as to divide the population with similar ovarian responses into one group.

Abstract: The disclosure relates to methods and systems incorporating physical modeling to identify the ultrafast laser/material interaction mechanisms and the impact of laser parameters, to optimize implementation of ultrafast laser-based processing for a given material. The process determines a laser fluence near the ablation threshold for a given material and given pulse duration. The repetition rate, scanning speed and scanning strategy are subsequently optimized to minimize heat accumulation, having an operable line scan overlap between 50% to 85% for achieving smooth ultrafast-laser polishing, while maintaining an optic-quality surface.