Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: The present disclosure relates to novel CDK inhibitors, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions associated with CDK.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: A carbon sink enhancement method based on oyster-Undaria pinnatifida integrated aquaculture is performed as follows. Oysters with similar size and appearance are selected, washed and evenly spread onto a bottom of an incubator, to which 5-15° C. seawater is added. A rope is fixed on an upper side wall of the incubator. Undaria pinnatifida seedlings are spacedly clamped on the rope for spaced hanging culture. A wet weight ratio of the oyster to the Undaria pinnatifida seedlings is 6-8:1. The incubator is placed under sunlight for mixed culture, during which the incubator remains closed without water replacement. The oysters or the Undaria pinnatifida seedlings are taken out when the oyster reaches a meat yield of 10% or more or a length of the Undaria pinnatifida seedlings is larger than 100 cm. Seawater samples are collected to detect water quality parameters for carbon sink assessment.

Abstract: The present disclosure relates to novel glutarimide-containing compounds with KRAS mutant form degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions.

Abstract: An audio transmission method includes: a second device sends noise energy data on the second device end and transmission efficiency data to a first device; the first device determines a first bit rate based on the noise energy data, and determines a second bit rate based on the transmission efficiency data; the first device encodes an audio stream based on a lower bit rate of the first bit rate and the second bit rate to obtain audio data; the first device sends the audio data obtained by encoding to the second device.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: The present disclosure relates to a compound of Formula (I), a tautomer, a stereoisomer or a mixture of stereoisomers, a pharmaceutically acceptable salt, a hydrate, or a deuterated derivative thereof and their use in, e.g., treating a disease or disorder associated with CDK2. The present disclosure also relates to pharmaceutical compositions containing such compounds, and their use in treating or preventing a disease or disorder associated with CDK2.

Abstract: The present application discloses a high-toughness ultrahigh-strength steel and a manufacturing method thereof, and belongs to the technical field of metal materials. The present application is intended to solve the problem that the existing low-alloy ultrahigh-strength steel has poor toughness and poor hardenability. The high-toughness ultrahigh-strength steel includes the following elements in mass percentages: C: 0.27% to 0.35%; Si: 1.10% to 1.70%; Mn: 0.70% to 1.10%; Cr: 1.00% to 1.40%; Ni: 0.10% to 0.50%; Mo: 0.05% to 0.50%; W: 0.05% to 0.10%; Nb: 0.01% to 0.04%; and iron and unavoidable impurities: the balance. The high-toughness ultrahigh-strength steel of the present application has excellent strength, toughness and hardenability.

Abstract: An integrated haptic system may include a digital signal processor and an amplifier communicatively coupled to the digital signal processor and integrated with the digital signal processor into the integrated haptic system. The digital signal processor may be configured to receive a force sensor signal indicative of a force applied to a force sensor and generate a haptic playback signal responsive to the force. The amplifier may be configured to amplify the haptic playback signal and drive a vibrational actuator communicatively coupled to the amplifier with the haptic playback signal as amplified by the amplifier.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: The present invention relates to a preparation process for a Cu-based catalyst and use of the Cu-based catalyst as the dehydrogenation catalyst in producing a hydroxyketone compound such as acetoin. Said Cu-based catalyst shows a high the acetoin selectivity as the dehydrogenation catalyst for producing acetoin.

Abstract: A user equipment assistance information (UAI) negotiation method, for a user equipment (UE) of mobile communication includes receiving a first OtherConfig element of an RRC reconfiguration message comprising a plurality of configuration parameters with SETUP values from a network terminal; sending a first UAI including a first value of a first configuration parameter of the configuration parameters to the network terminal; and receiving a first RRC reconfiguration message corresponding to the first UAI from the network terminal.

Abstract: An integrated haptic system may include a digital signal processor and an amplifier communicatively coupled to the digital signal processor and integrated with the digital signal processor into the integrated haptic system. The digital signal processor may be configured to receive a force sensor signal indicative of a force applied to a force sensor and generate a haptic playback signal responsive to the force. The amplifier may be configured to amplify the haptic playback signal and drive a vibrational actuator communicatively coupled to the amplifier with the haptic playback signal as amplified by the amplifier.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: A method for dynamically de-activating a secondary cell group (SCG) of dual connectivity includes: checking if at least one radio frequency (RF) band used by the SCG meets a pre-defined criterion, and in response to the at least one RF band meeting the pre-defined criterion, de-activating the SCG. For example, the at least one RF band is a 5G New Radio (NR) band.

Abstract: The present disclosure relates to novel glutarimide-containing compounds with KRAS mutant form degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions.

Abstract: The present disclosure relates to novel SOS1 inhibitors, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: A carbon sink enhancement method based on oyster-Undaria pinnatifida integrated aquaculture is performed as follows. Oysters with similar size and appearance are selected, washed and evenly spread onto a bottom of an incubator, to which 5-15° C. seawater is added. A rope is fixed on an upper side wall of the incubator. Undaria pinnatifida seedlings are spacedly clamped on the rope for spaced hanging culture. A wet weight ratio of the oyster to the Undaria pinnatifida seedlings is 6-8:1. The incubator is placed under sunlight for mixed culture, during which the incubator remains closed without water replacement. The oysters or the Undaria pinnatifida seedlings are taken out when the oyster reaches a meat yield of 10% or more or a length of the Undaria pinnatifida seedlings is larger than 100 cm. Seawater samples are collected to detect water quality parameters for carbon sink assessment.