Patents by Inventor Jiechao Liu

Jiechao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11771679
    Abstract: The present invention discloses a composition containing hesperetin and synergistic hypoglycemic application thereof, and belongs to the technical field of natural active compounds. The composition of the present invention contains the hesperetin and a compound X, and the compound X is galangin or formononetin, where a mass ratio of the hesperetin to the galangin is 30:100, and a mass ratio of the hesperetin to the formononetin is 30:20. The composition of the present invention has an obvious synergistic effect of inhibiting ?-glucosidase, and the effect thereof is better than that of using the flavonoid compound alone, and may reduce a dosage of the use of drugs and occurrence of drug resistance.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: October 3, 2023
    Assignee: ZHENGZHOU FRUIT RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Qiang Zhang, Zhonggao Jiao, Dalei Chen, Jiechao Liu, Wenbo Yang, Chunling Zhang, Hui Liu, Zhenzhen Lv, Junkun Pan
  • Patent number: 11753388
    Abstract: The present invention discloses a composition for inhibiting ?-glucosidase and application thereof, and belongs to the technical field of natural active compounds. The composition of the present invention contains daidzein and quercetin derivatives, and the quercetin derivative is taxifolin or 3-O-methyl quercetin, where the mass ratio of the daidzein to the taxifolin is 8:25-10:25; and the mass ratio of the daidzein to the 3-O-methyl quercetin is 8:2-8:4. The composition of the present invention has an obvious synergistic effect of inhibiting ?-glucosidase, and the effect thereof is better than that of using the flavonoid compound alone, and may reduce a dosage of the use of drugs and occurrence of drug resistance.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: September 12, 2023
    Assignee: ZHENGZHOU FRUIT RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Jiechao Liu, Qiang Zhang, Zhonggao Jiao, Dalei Chen, Junkun Pan, Chunling Zhang, Hui Liu, Wenbo Yang, Zhenzhen Lv
  • Publication number: 20230129488
    Abstract: The present invention discloses a composition for inhibiting ?-glucosidase and application thereof, and belongs to the technical field of natural active compounds. The composition of the present invention contains daidzein and quercetin derivatives, and the quercetin derivative is taxifolin or 3-O-methyl quercetin, where the mass ratio of the daidzein to the taxifolin is 8:25-10:25; and the mass ratio of the daidzein to the 3-O-methyl quercetin is 8:2-8:4. The composition of the present invention has an obvious synergistic effect of inhibiting ?-glucosidase, and the effect thereof is better than that of using the flavonoid compound alone, and may reduce a dosage of the use of drugs and occurrence of drug resistance.
    Type: Application
    Filed: December 15, 2022
    Publication date: April 27, 2023
    Inventors: Jiechao LIU, Qiang ZHANG, Zhonggao JIAO, Dalei CHEN, Junkun PAN, Chunling ZHANG, Hui LIU, Wenbo YANG, Zhenzhen LV
  • Publication number: 20230125518
    Abstract: The present invention discloses a composition containing hesperetin and synergistic hypoglycemic application thereof, and belongs to the technical field of natural active compounds. The composition of the present invention contains the hesperetin and a compound X, and the compound X is galangin or formononetin, where a mass ratio of the hesperetin to the galangin is 30:100, and a mass ratio of the hesperetin to the formononetin is 30:20. The composition of the present invention has an obvious synergistic effect of inhibiting ?-glucosidase, and the effect thereof is better than that of using the flavonoid compound alone, and may reduce a dosage of the use of drugs and occurrence of drug resistance.
    Type: Application
    Filed: December 15, 2022
    Publication date: April 27, 2023
    Inventors: Qiang ZHANG, Zhonggao JIAO, Dalei CHEN, Jiechao LIU, Wenbo YANG, Chunling ZHANG, Hui LIU, Zhenzhen LV, Junkun PAN
  • Patent number: 10870612
    Abstract: A method for simultaneously extracting Lycopene and Citrulline from a watermelon includes: separating the rind and the pulp of the watermelon, preprocessing the rind, and using the preprocessed rind to extract the Citrulline; subjecting the pulp to biological enzymolysis and filtering, centrifuging a filtrate, using a precipitate and a filter residue obtained after the centrifuging to extract the Lycopene, and using a supernatant obtained after the centrifuging to extract the Citrulline. By using the method for synchronously extracting Lycopene and Citrulline from the watermelon of the present invention, about 0.5 kg of Lycopene (6% content) and more than 1.2 kg of Citrulline which are worthy of nearly ten thousand yuan can be extracted from each ton of imperfect watermelons, the economic benefit of each ton of watermelons can be increased by more than 5000 yuan after extraction costs are deducted, and the method is high in economic benefits.
    Type: Grant
    Filed: May 31, 2020
    Date of Patent: December 22, 2020
    Assignee: ZHENGZHOU FRUIT RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Zhonggao Jiao, Jiechao Liu, Chunling Zhang, Qiang Zhang, Hui Liu, Zhenzhen Lv, Wenbo Yang, Dalei Chen
  • Publication number: 20200385323
    Abstract: A method for simultaneously extracting Lycopene and Citrulline from a watermelon includes: separating the rind and the pulp of the watermelon, preprocessing the rind, and using the preprocessed rind to extract the Citrulline; subjecting the pulp to biological enzymolysis and filtering, centrifuging a filtrate, using a precipitate and a filter residue obtained after the centrifuging to extract the Lycopene, and using a supernatant obtained after the centrifuging to extract the Citrulline. By using the method for synchronously extracting Lycopene and Citrulline from the watermelon of the present invention, about 0.5 kg of Lycopene (6% content) and more than 1.2 kg of Citrulline which are worthy of nearly ten thousand yuan can be extracted from each ton of imperfect watermelons, the economic benefit of each ton of watermelons can be increased by more than 5000 yuan after extraction costs are deducted, and the method is high in economic benefits.
    Type: Application
    Filed: May 31, 2020
    Publication date: December 10, 2020
    Inventors: Zhonggao JIAO, Jiechao LIU, Chunling ZHANG, Qiang ZHANG, Hui LIU, Zhenzhen LV, Wenbo YANG, Dalei CHEN
  • Patent number: 10837035
    Abstract: The present invention relates to the technical field of natural substance extraction. Disclosed is a method for extracting Citrulline from a watermelon. The method for extracting Citrulline from a watermelon in the present invention comprises Raw material pretreatment, ultrasound-enzymatic hydrolysis assisted solvent leaching, and purification steps. The purification step comprises microbial fermentation, ion-exchange resin purification, macroporous adsorption resin discoloration, and crystallization and recrystallization. The method for extracting Citrulline in the present invention is simple, requires a mild condition, and has a good extraction effect on Citrulline. The purity of Citrulline after purification is more than 90%. In addition, the Citrulline extracted by the method in the present invention meets the related health requirements and product quality standards, can be applied to food and health food industries as a raw material, and has natural security advantages.
    Type: Grant
    Filed: May 31, 2020
    Date of Patent: November 17, 2020
    Assignee: ZHENGZHOU FRUIT RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Zhonggao Jiao, Jiechao Liu, Chunling Zhang, Qiang Zhang, Hui Liu, Zhenzhen Lv, Wenbo Yang, Dalei Chen
  • Publication number: 20200291437
    Abstract: The present invention relates to the technical field of natural substance extraction. Disclosed is a method for extracting Citrulline from a watermelon. The method for extracting Citrulline from a watermelon in the present invention comprises Raw material pretreatment, ultrasound-enzymatic hydrolysis assisted solvent leaching, and purification steps. The purification step comprises microbial fermentation, ion-exchange resin purification, macroporous adsorption resin discoloration, and crystallization and recrystallization. The method for extracting Citrulline in the present invention is simple, requires a mild condition, and has a good extraction effect on Citrulline. The purity of Citrulline after purification is more than 90%. In addition, the Citrulline extracted by the method in the present invention meets the related health requirements and product quality standards, can be applied to food and health food industries as a raw material, and has natural security advantages.
    Type: Application
    Filed: May 31, 2020
    Publication date: September 17, 2020
    Inventors: Zhonggao JIAO, Jiechao LIU, Chunling ZHANG, Qiang ZHANG, Hui LIU, Zhenzhen LV, Wenbo YANG, Dalei CHEN
  • Patent number: 8948972
    Abstract: A vehicle controlling method which includes detecting an engagement of a vehicle tire with a rumble strip of a road, and performing first and second vehicle controls. The first vehicle control includes operating a controller to control movement of the vehicle after the vehicle tire has disengaged from the rumble strip to bring the vehicle tire back into engagement with the rumble strip. The second vehicle control includes operating the controller to continue to control movement of the vehicle to maintain the vehicle tire in engagement with the rumble strip after the vehicle tire has been brought back into engagement with the rumble strip.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: February 3, 2015
    Assignees: Nissan North America, Inc., The University of Michigan
    Inventors: Jiechao Liu, Timothy Gordon, Ronald Heft
  • Publication number: 20140249718
    Abstract: A vehicle controlling method which includes detecting an engagement of a vehicle tire with a rumble strip of a road, and performing first and second vehicle controls. The first vehicle control includes operating a controller to control movement of the vehicle after the vehicle tire has disengaged from the rumble strip to bring the vehicle tire back into engagement with the rumble strip. The second vehicle control includes operating the controller to continue to control movement of the vehicle to maintain the vehicle tire in engagement with the rumble strip after the vehicle tire has been brought back into engagement with the rumble strip.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 4, 2014
    Applicants: THE UNIVERSITY OF MICHIGAN, NISSAN NORTH AMERICA, INC.
    Inventors: Jiechao Liu, Timothy Gordon, Ronald Heft