Abstract: The present invention relates to novel peptides, composition comprising such peptides including nutritional supplements and methods for inducing satiation and satiety, for weight management and preventing or reducing the incidence of obesity, or for preventing or reducing cardiovascular diseases, atherosclerosis, hypertension, hepatosteatosis, cancer and/or diabetes.

Abstract: The disclosure discloses a stuck staple processing mechanism of an electric stapler and the electric stapler. The stuck staple processing mechanism of the electric stapler includes a driving mechanism, a transmission mechanism, a pop-up staple channel assembly, a controller and a pop-up mechanism. The transmission mechanism is connected with a pop-up switch of the pop-up staple channel assembly through the pop-up mechanism. When the controller controls the driving mechanism to rotate along a staple placing direction, the pop-up mechanism does not make the staple channel assembly act. When the controller controls the driving mechanism to rotate in an opposite direction of staple placing, the transmission mechanism makes the pop-up switch act through the pop-up mechanism to pop up a staple channel of the staple channel assembly, so as to facilitate a removal of a stuck staple.

Abstract: Provided are methods for treatment of cancer by administering to an individual who has a cancer that includes cancer cells that have an LKBI mutation an anti-CD38 agent, an inhibitor of EP300, or a combination thereof. Methods are also provided for treating an individual who has a cancer that includes cancer cells that do not have an LKBI mutation a Salt-Inducible Kinase (SIK) inhibitor and an anti-CD38 agent. The SIK inhibitors sensitizes the cancer cells that do not have the LKBI mutation to the anti-CD38 agent.

Abstract: A multistage energy utilization system based on electricity-heat-hydrogen-methane coupling is connected with a power grid, a heat-supply network and a gas-supply network. The system includes a renewable energy resource module, a hydrogen energy storage module, a heat storage module, a gas fired-boiler module, a methane reactor module and a carbon capture and storage (CCS) module. The renewable energy resource module is connected with the power grid and the hydrogen energy storage module. The hydrogen energy storage module is connected with the power grid, the heat-supply network and the methane reactor module. The methane reactor module is connected with the hydrogen energy storage module, the CCS module and the gas-supply network. The gas fired-boiler module is connected with the gas-supply network. The hydrogen energy storage module, the CCS module and the methane reactor module are integrated to improve energy utilization and consumption level of renewable energy resources.

Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: The present disclosure generally relates to semiconductor structures and, more particularly, to gate structures and methods of manufacture. The method includes: forming a first gate structure and a second gate structure with gate materials; etching the gate materials within the second gate structure to form a trench; and depositing a conductive material within the trench so that the second gate structure has a metal composition different than the first gate structure.

Abstract: The disclosure discloses a stuck staple processing mechanism of an electric stapler and the electric stapler. The stuck staple processing mechanism of the electric stapler includes a driving mechanism, a transmission mechanism, a pop-up staple channel assembly, a controller and a pop-up mechanism. The transmission mechanism is connected with a pop-up switch of the pop-up staple channel assembly through the pop-up mechanism. When the controller controls the driving mechanism to rotate along a staple placing direction, the pop-up mechanism does not make the staple channel assembly act. When the controller controls the driving mechanism to rotate in an opposite direction of staple placing, the transmission mechanism makes the pop-up switch act through the pop-up mechanism to pop up a staple channel of the staple channel assembly, so as to facilitate a removal of a stuck staple.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to self-aligned contacts and methods of manufacture. The structure includes: adjacent diffusion regions located within a substrate material; sidewall structures above an upper surface of the substrate material, aligned on sides of the adjacent diffusion regions; and a contact between the sidewall structures and extending to within the substrate material between and in electrical contact with the adjacent diffusion regions.

Abstract: A gate cut isolation including an air gap and an IC including the same are disclosed. A method of forming the gate cut isolation may include forming an opening in a dummy gate that extends over a plurality of spaced active regions, the opening positioned between and spaced from a pair of active regions. The opening is filled with a fill material, and the dummy gate is removed. A metal gate is formed in a space vacated by the dummy gate on each side of the fill material, and the fill material is removed to form a preliminary gate cut opening. A liner is deposited in the preliminary gate cut opening, creating a gate cut isolation opening, which is then sealed by depositing a sealing layer. The sealing layer closes an upper end of the gate cut isolation opening and forms the gate cut isolation including an air gap.

Abstract: The present invention relates to novel peptides, composition comprising such peptides including nutritional supplements and methods for inducing satiation and satiety, for weight management and preventing or reducing the incidence of obesity, or for preventing or reducing cardiovascular diseases, atherosclerosis, hypertension, hepatosteatosis, cancer and/or diabetes.

Abstract: Structures for a field-effect transistor and methods of forming a structure for a field-effect transistor. A gate structure is arranged over a channel region of a semiconductor body. A first source/drain region is coupled to a first portion of the semiconductor body, and a second source/drain region is located in a second portion the semiconductor body. The first source/drain region includes an epitaxial semiconductor layer containing a first concentration of a dopant. The second source/drain region contains a second concentration of the dopant. The channel region is positioned in the semiconductor body between the first source/drain region and the second source/drain region.

Abstract: This application provides a data recovery method and apparatus, and relates to the field of computer technologies. The method includes: determining first data, where the first data is application data generated when an application program runs normally; storing the first data in a handle record, where the handle record is managed by using a reference count mechanism; and when the application program is unexpectedly restarted, obtaining the handle record, and restoring the application program, based on the handle record, to a status before the application program is unexpectedly restarted.