Patents by Inventor JIELEI NI

JIELEI NI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12276809
    Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: April 15, 2025
    Assignee: BGI SHENZHEN
    Inventors: Jielei Ni, Ming Ni, Fan Zhou, Zeyu Su, Ke Ji, Dong Wei, Mengzhe Shen, Yuanqing Liang, Mei Li, Xun Xu
  • Publication number: 20250060311
    Abstract: Disclosed are a method for increasing a sequencing resolution, and a sequencing device and system. The method includes carrying out irradiation and excitation on a sample to be tested containing a fluorescent dye with at least one type of excitation light to generate a fluorescence signal, where a maximum wavelength in the excitation light is smaller than a wavelength of red light; and the transmitting the generated fluorescence signal through an optical path, and collecting and imaging the signal.
    Type: Application
    Filed: November 12, 2021
    Publication date: February 20, 2025
    Inventors: Zeyu Su, Yuanqing Liang, Mengzhe Shen, Jielei Ni
  • Publication number: 20240369489
    Abstract: An illumination chip includes an illumination array structure and an illumination well. The illumination array structure includes a substrate and multiple illumination units periodically distributed on the substrate. The illumination well is disposed on a surface, extending along the multiple illumination units, of the illumination array structure, where the illumination well is divided into multiple placement units which are configured to place samples, and each placement unit (841) is disposed above a corresponding illumination unit. Illumination units of the multiple illumination units are configured to generate, in a case where the illumination units of the multiple illumination units are illuminated by a light source, surface plasmon structured light to excite fluorescent dyes of samples in corresponding placement units of the multiple placement units, and generate a fluorescence signal.
    Type: Application
    Filed: August 16, 2021
    Publication date: November 7, 2024
    Inventors: Fan ZHOU, Shaozhuang YANG, Jielei NI, Mengzhe SHEN, Xun XU
  • Publication number: 20240085717
    Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.
    Type: Application
    Filed: March 9, 2020
    Publication date: March 14, 2024
    Inventors: JIELEI NI, MING NI, FAN ZHOU, ZEYU SU, KE JI, DONG WEI, MENGZHE SHEN, YUANQING LIANG, MEI LI, XUN XU