Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a target ligand. The target ligand provided by the present disclosure forms a siRNA conjugate with a specific small interfering RNA sequence, which targets to an angiopoietin like 3 (ANGPTL3), and reduce the expression quantity of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA conjugate formed by the target ligand provided by the present disclosure may be used to prevent and/or treat a dyslipidemia disease.

Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a siRNA of an angiopoietin like 3 (ANGPTL3) and a use thereof. The inventor of the present disclosure targets to ANGPTL3 by designing an appropriate specific small interfering RNA sequence and a siRNA conjugate, and reduce the expression of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA provided in the present disclosure may be used to prevent and/or treat a dyslipidemia disease.

Abstract: A wind turbine blade is provided which includes a root section, a transition section, a conventional section and a tip section. The root section may include a chord length that is greater than a chord length calculated using conventional equations by a factor of approximately 1.3. The root section may also include a blade setting angle that is greater than a blade setting angle calculated using conventional equations by a factor of approximately 1.3. The conventional section may include a chord length and/or a blade setting angle that is approximately equal to a chord length and/or a blade setting angle calculated using conventional equations. In the transition section, the chord length and/or blade setting angle may transition from the chord length and/or blade setting angle in the root section to the chord length and/or blade setting angle in the conventional section. The tip section may include a winglet.