Patents by Inventor Jieyi Wang

Jieyi Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN KINASE INHIBITORS
    Publication number: 20090253723
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: November 20, 2008
    Publication date: October 8, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Nwe Y. Ba-Maung, Randy L. Bell, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Robert D. Hubbard, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • Antiangiogenic peptides, polypeptides encoding same and methods for inhibiting angiogenesis
    Patent number: 7495068
    Abstract: Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: February 24, 2009
    Assignee: Abbott Laboratories
    Inventors: Donald J. Davidson, Jieyi Wang, Earl J. Gubbins
  • Sulfonamides having antiangiogenic and anticancer activity
    Patent number: 7491718
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • PROTEIN KINASE INHIBITORS
    Publication number: 20070203143
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 30, 2007
    Inventors: George Sheppard, Gary Wang, Fabio Palazzo, Randy Bell, Robert Mantei, Jieyi Wang, Robert Hubbard, Megumi Kawai, Scott Erickson, Nwe BaMaung, Steve Fidanze
  • 3-Amino-2-hydroxyalkanoic acids and their prodrugs
    Patent number: 7030262
    Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: April 18, 2006
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Patent number: 6887863
    Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: May 3, 2005
    Assignee: Abbott Laboratories
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung, Xenia Beebe Searle
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Publication number: 20040167126
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: February 19, 2004
    Publication date: August 26, 2004
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung, Xenia Beebe Searle
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040167128
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: August 26, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040157836
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: September 23, 2003
    Publication date: August 12, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Novel antiangiogenic peptides, polypeptides encoding same and methods for inhibiting angiogenesis
    Publication number: 20040138127
    Abstract: Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 15, 2004
    Inventors: Donald J. Davidson, Jieyi Wang, Earl J. Gubbins
  • 3-Amino-2-hydroxyalkanoic acids and their prodrugs
    Publication number: 20040122098
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: August 6, 2003
    Publication date: June 24, 2004
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang
  • Novel methionine aminopeptidase-2 and uses thereof
    Publication number: 20040077031
    Abstract: The present invention uses the manganese-dependent physiological form of the enzyme methionine aminopeptidase type 2 to assess inhibition by agents that might be used in the treatment of angiogenesis, cancer, malaria and leishmaniasis. This method has the advantage of using the manganese form of the enzyme and therefore, the advantage of identifying potent inhibitors that might not show activity in cellular systems because the wrong metal cofactor is used. Therefore it is a new tool for the development of agents useful in the therapy of cancer and other angiogenesis-related diseases and, several infectious diseases including malaria, leishmaniais and microsporidiosis.
    Type: Application
    Filed: October 17, 2002
    Publication date: April 22, 2004
    Inventors: Jieyi Wang, George S. Sheppard, PingPing Lou, Jack Henkin
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040068012
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2002
    Publication date: April 8, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki Hwan Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang
  • HIGHLY CRYSTALLINE UROKINASE
    Publication number: 20020106775
    Abstract: The present disclosure describes a biologically active modified urokinase and high resolution crystalline forms of modified urokinase. Polynucleotides which encode modified urokinase and methods for making modified urokinase are also disclosed.
    Type: Application
    Filed: March 5, 1999
    Publication date: August 8, 2002
    Inventors: JIEYI WANG, VICKI L. NIENABER, JACK HENKIN, RICHARD A. SMITH, KARL A. WALTER, JEAN M. SEVERIN, ROHINTON EDALJI, ROBERT W. JOHNSON, THOMAS F. HOLZMAN
  • 3-substituted indole antiproliferative angiogenesis inhibitors
    Publication number: 20020091148
    Abstract: 3-Substituted indole carbohydrazides having the formula 1
    Type: Application
    Filed: September 14, 2001
    Publication date: July 11, 2002
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Megumi Kawai, Jieyi Wang, Yujia Dai, Yan Guo, George Sheppard, Mary K. Verzal, Anil Vasudevan, Michael Michaelides
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Publication number: 20020002152
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 12, 2001
    Publication date: January 3, 2002
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung
  • 3-substituted indole angiogenesis inhibitors
    Patent number: 6323228
    Abstract: 3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: November 27, 2001
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Megumi Kawai, Jieyi Wang
  • Substituted &bgr;-amino acid inhibitors of methionine aminopeptidase-2
    Patent number: 6242494
    Abstract: A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: June 5, 2001
    Assignee: Abbott Laboratories
    Inventors: Richard A. Craig, Jack Henkin, Megumi Kawai, Linda M. Lynch, Jyoti Patel, George S. Sheppard, Jieyi Wang