Patents by Inventor Jifen LI

Jifen LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Modulating Single Stranded DNA Regions that Catalyze Enzymatic Reactions
    Publication number: 20250011785
    Abstract: Described are novel DNAzyme constructs with porphyrin metalation activity, methods of making and using them, as well as methods of identifying novel DNAzymes and methods of modulating the activity of DNAzymes.
    Type: Application
    Filed: July 5, 2024
    Publication date: January 9, 2025
    Inventors: James Eberwine, Sergei Vinogradov, Srinivasa Rao Allu, Jifen Li, Youtao Lu, Junhyong Kim
  • COMPOSITIONS AND METHODS FOR GENOMIC DNA AND GENE EXPRESSION ANALYSIS IN SINGLE CELLS
    Publication number: 20240011025
    Abstract: Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA. These methods also provide for gene specific 3D chromatin structural niche analysis.
    Type: Application
    Filed: June 15, 2023
    Publication date: January 11, 2024
    Applicants: Agilent Technologies, Inc., The Trustees of the University of Pennsylvania
    Inventors: James EBERWINE, Jae-Hee LEE, Jifen LI, Stephen FISHER, Youtao LU, Junhyong KIM, Jai-Yoon SUL, Jinchun WANG, Mimi HEALY
  • Compositions and methods for genomic DNA and gene expression analysis in single cells
    Patent number: 11739321
    Abstract: Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA. These methods also provide for gene specific 3D chromatin structural niche analysis.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: August 29, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: James Eberwine, Jae-Hee Lee, Jifen Li, Stephen Fisher, Youtao Lu, Junhyong Kim, Jai-Yoon Sul, Jinchun Wang, Mimi Healy
  • COMPOSITIONS AND METHODS FOR GENOMIC DNA AND GENE EXPRESSION ANALYSIS IN SINGLE CELLS
    Publication number: 20200216841
    Abstract: Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA. These methods also provide for gene specific 3D chromatin structural niche analysis.
    Type: Application
    Filed: January 7, 2020
    Publication date: July 9, 2020
    Applicants: Agilent Technologies, Inc., The Trustees of the University of Pennsylvania
    Inventors: James EBERWINE, Jae-Hee LEE, Jifen LI, Stephen FISHER, Youtao LU, Junhyong KIM, Jai-Yoon SUL, Jinchun WANG, Mimi HEALY