Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: A currency disinfecting assembly for sterilizing paper currency includes a cabinet that is comprised of an opaque material to inhibit light from passing therethrough. A plurality of holders is each disposed in an interior of the cabinet to accommodate paper currency. A plurality of light emitters is each coupled to the cabinet to emit light outwardly therefrom. Each of the light emitters is positioned inside of the cabinet to direct the light onto the paper currency. Moreover, each of the light emitters emits light in the ultraviolet spectrum to sterilize the paper currency.

Abstract: A computer-implemented process receives unstructured patient data pertaining to a patient. Furthermore, the computer-implemented process eliminates redundant words from the unstructured patient data. Additionally, the computer-implemented process generates a numerical representation of the unstructured patient data and a context-specific textual representation of the unstructured patient data. The computer-implemented process classifies, via the machine learning engine, one or more potential portions of the context-specific textual representation of the unstructured data in a risk stratification category. Additionally, the computer-implemented process determines that one or more potential corresponding portions of the numerical representation is also classified in the risk stratification category. Finally, the computer-implemented process outputs, in real-time, an enhancement to the risk stratification category based on the numerical representation also being classified in the risk stratification category.

Abstract: A laser treatment system includes a sensor configured to detect a targeted therapy region. A processing unit is configured to generate a treatment path that consists of sequentially arranged laser spots to enable the treatment path to fully encompass a targeted therapy region to receive laser therapy. A steering device is alerted to move to a plurality of positions based on the treatment plan generated by the processing unit. A treatment laser provides laser therapy to the plurality of positions and targeted therapy region based on the treatment plan generated by the processing unit.

Abstract: Methods, systems, and computing platforms are disclosed. Exemplary implementations may: identify and store anatomical landmarks on a first reference digital image of a region of a human body; insert biopsy site identification data on the first reference digital image with the anatomical landmarks to form a second reference digital image; transform the second reference digital image into a mesh mask image; and overlay the mesh mask image on a third digital image of the region of the human body.

Abstract: Disclosed are systems and techniques for providing laser treatment. For example, a vasculature structure associated with a tissue region can be determined. Based on the vasculature structure, one or more laser parameters for configuring a laser to deliver laser energy to at least one blood vessel within the tissue region can be determined. Laser energy can be delivered to the at least one blood vessel to halt blood flow to a targeted area within the tissue region.

Abstract: The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.

Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

Abstract: The disclosure provides compositions comprising at least one assembly comprising a peptide and a major histocompatibility complex (MHC), wherein the peptide is an integral component of the MHC, wherein the peptide is attached to a surface at its C-terminus through a linker and wherein the peptide is synthesized on the surface. In certain embodiments, the compositions comprise a plurality of assemblies in a spatially-ordered array. The disclosure provides methods for making and using these compositions.

Abstract: The present invention relates to methods for detecting a target molecule in a liquid sample. The methods described herein comprise applying at least a portion of the liquid sample on a solid substrate that comprises a non-fouling polymer layer, decreasing the atmospheric pressure surrounding the solid substrate containing the portion of the liquid sample for a time sufficient for a majority of the liquid to evaporate from the portion of the liquid sample applied to the solid substrate, contacting the liquid sample with one or more binding agents that binds to the target molecule after the majority of the liquid has evaporated from the liquid sample, and detecting the presence of the one or more binding agents on the solid substrate, wherein the presence of the one or more binding agents indicates the presence of the target molecule in the liquid sample.

Abstract: A currency disinfecting assembly for sterilizing paper currency includes a cabinet that is comprised of an opaque material to inhibit light from passing therethrough. A plurality of holders is each disposed in an interior of the cabinet to accommodate paper currency. A plurality of light emitters is each coupled to the cabinet to emit light outwardly therefrom. Each of the light emitters is positioned inside of the cabinet to direct the light onto the paper currency. Moreover, each of the light emitters emits light in the ultraviolet spectrum to sterilize the paper currency.

Abstract: The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The present technology provides an approach to designing libraries of peptide sequences for discovery and testing of significantly more motifs than would be otherwise available in a given fixed library format. The technology includes a plurality of x-mers embedded in N-mer peptides sequences, where N and x are integers and where N is greater than x. This approach provides for the representation of multiple unique x-mer peptides in a single N-mer peptide feature.

Abstract: In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases. In another aspect, the present disclosure provides glutamine-containing substrates (or Q-tag substrates) that are more resistant to proteases/clipping and therefore, more stable, than other Q-tag substrates, and their uses in substrate tags for cross-linking to an amine-donor tag via an isopeptide bond mediated by a microbial transglutaminase.

Abstract: According to one aspect, the present disclosure provides a method of identifying a substrate of a transglutaminase using a peptide array comprising a plurality of peptides. The method includes the steps of contacting the peptides in the peptide array with the transglutaminase, allowing the transglutaminase to bind to the peptides, and identifying the substrate of the transglutaminase.

Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.

Abstract: The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.