Patents by Inventor Jigar Patel

Jigar Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210285049
    Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.
    Type: Application
    Filed: June 14, 2019
    Publication date: September 16, 2021
    Inventors: Nelson R. Alexander, Aoune Barhoumi, Jan Berka, Rui Chen, Lisa L. Gallegos, Toumy Guettouche, Seoyoung Kim, Maeve E. O'Huallachain, Sedide Ozturk, Jigar Patel, Florian Rubelt, Stacey Stanislaw
  • Patent number: 11117183
    Abstract: A feeder for a swage gun comprises a collar magazine and a guide-block assembly. The guide-block assembly comprises a guide block that comprises a slot, configured to receive the lock collar from the collar magazine at a first guide-block position along the slot. The guide-block assembly also comprises an actuator, operable to move the lock collar along the slot from the first guide-block position to a second guide-block position. Feeder further comprises a feed tunnel, coupled with the guide-block assembly, and a dispensing bulkhead, coupled with the feed tunnel. Feeder also comprises a gripping assembly, coupled with the dispensing bulkhead.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: September 14, 2021
    Assignee: The Boeing Company
    Inventors: John W. Pringle, IV, David Pedersen, Matt Barnhart, David Lepore, Yousef Aziz, Jigar Patel, Surajit Roy
  • Publication number: 20210238186
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: June 25, 2019
    Publication date: August 5, 2021
    Inventors: Nadiya Sydorenko, Md Rauful Alam, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Aleksey I. Gerasyuto, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Matthew G. Woll, Wuming Yan, Nanjing Zhang
  • Patent number: 11079389
    Abstract: The present invention provides a method for identifying a synthetic classifier including contacting at least a first and second samples derived from different groups of a cohort with a first plurality of peptides. The first plurality of peptides includes a first subset of peptides defining at least one naturally occurring amino acid sequence, and a second subset of peptides defining a plurality of variants of the first subset of peptides. The plurality of variants includes, for each one of the first subset of peptides, a variant peptide having at least one of a substitution, a deletion, an insertion, an extension, and a modification. The method further includes selecting at least one of the plurality of variants from the second subset of peptides, and defining a synthetic classifier including the at least one of the plurality of variants that distinguishes between samples derived from the first and second cohorts.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: August 3, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Hanying Li, Ken Lo, Jigar Patel
  • Patent number: 11054425
    Abstract: In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases. In another aspect, the present disclosure provides glutamine-containing substrates (or Q-tag substrates) that are more resistant to proteases/clipping and therefore, more stable, than other Q-tag substrates, and their uses in substrate tags for cross-linking to an amine-donor tag via an isopeptide bond mediated by a microbial transglutaminase.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: July 6, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Thomas Albert, Frank Bergmann, Victor Lyamichev, Mohamed Yosry Hassan Mohamed, Tobias Oelschlaegel, Jigar Patel, Michael Schraeml, Wojtek Steffen, Thomas Streidl
  • Patent number: 10976317
    Abstract: The invention comprises systems, methods and arrays for identification and optimization of novel peptide binders to protein targets. Embodiments include steps of peptide binder discovery, core peptide maturation, N-terminal and C-terminal extension and kinetics analysis of the final peptide binder.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: April 13, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Jigar Patel, Victor Lyamichev, Thomas Albert
  • Patent number: 10970738
    Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: April 6, 2021
    Assignee: THE TICKET FAIRY, INC.
    Inventors: Ritesh Patel, Jigar Patel
  • Patent number: 10947272
    Abstract: The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 16, 2021
    Assignees: Hoffmann-La Roche Inc., ROCHE NIMBLEGEN, INC.
    Inventors: Jeremy Beauchamp, Per-Ola Freskgard, Eric A. Kitas, Victor Lyamichev, Jigar Patel
  • Publication number: 20200371102
    Abstract: In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases. In another aspect, the present disclosure provides glutamine-containing substrates (or Q-tag substrates) that are more resistant to proteases/clipping and therefore, more stable, than other Q-tag substrates, and their uses in substrate tags for cross-linking to an amine-donor tag via an isopeptide bond mediated by a microbial transglutaminase.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Inventors: Thomas Albert, Frank Bergmann, Victor Lyamichev, Mohamed Yosry Hassan Mohamed, Tobias Oelschlaegel, Jigar Patel, Michael Schraeml, Wojtek Steffen, Thomas Streidl
  • Publication number: 20200309783
    Abstract: The present invention provides a method for identifying a synthetic classifier including contacting at least a first and second samples derived from different groups of a cohort with a first plurality of peptides. The first plurality of peptides includes a first subset of peptides defining at least one naturally occurring amino acid sequence, and a second subset of peptides defining a plurality of variants of the first subset of peptides. The plurality of variants includes, for each one of the first subset of peptides, a variant peptide having at least one of a substitution, a deletion, an insertion, an extension, and a modification. The method further includes selecting at least one of the plurality of variants from the second subset of peptides, and defining a synthetic classifier including the at least one of the plurality of variants that distinguishes between samples derived from the first and second cohorts.
    Type: Application
    Filed: June 3, 2020
    Publication date: October 1, 2020
    Inventors: Hanying LI, Ken LO, Jigar PATEL
  • Patent number: 10788495
    Abstract: In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: September 29, 2020
    Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
    Inventors: Thomas Albert, Frank Bergmann, Victor Lyamichev, Jigar Patel, Michael Schraeml, Wojtek Steffen, Thomas Streidl
  • Publication number: 20200249231
    Abstract: In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases. In another aspect, the present disclosure provides glutamine-containing substrates (or Q-tag substrates) that are more resistant to proteases/clipping and therefore, more stable, than other Q-tag substrates, and their uses in substrate tags for cross-linking to an amine-donor tag via an isopeptide bond mediated by a microbial transglutaminase.
    Type: Application
    Filed: February 7, 2020
    Publication date: August 6, 2020
    Inventors: Thomas Albert, Frank Bergmann, Victor Lyamichev, Mohamed Yosry Hassan Mohamed, Tobias Oelschlaegel, Jigar Patel, Michael Schraeml, Wojtek Steffen, Thomas Streidl
  • Patent number: 10697973
    Abstract: The present invention provides a method for identifying a synthetic classifier including contacting at least a first and second samples derived from different groups of a cohort with a first plurality of peptides. The first plurality of peptides includes a first subset of peptides defining at least one naturally occurring amino acid sequence, and a second subset of peptides defining a plurality of variants of the first subset of peptides. The plurality of variants includes, for each one of the first subset of peptides, a variant peptide having at least one of a substitution, a deletion, an insertion, an extension, and a modification. The method further includes selecting at least one of the plurality of variants from the second subset of peptides, and defining a synthetic classifier including the at least one of the plurality of variants that distinguishes between samples derived from the first and second cohorts.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: June 30, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Hanying Li, Ken Lo, Jigar Patel
  • Publication number: 20200165256
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: June 5, 2018
    Publication date: May 28, 2020
    Inventors: Matthew G. Woll, Lukiana Amedzo, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Anthony R. Mazzotti, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Zhenrong Xu
  • Patent number: 10641778
    Abstract: The present invention provides a system and method for assessing the fidelity of a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a plurality of binder sequences. A first amino acid is at a defined position within a first one of the binder sequences, and the population of peptide features includes a first control peptide feature synthesized to have an amino acid sequence including the first one of the binder sequences. The system and method further includes detecting a signal output characteristic of an interaction of the receptor with the first control peptide feature. The signal output is indicative of the fidelity of incorporation of the first amino acid into the first control peptide at the defined position within the first one of the binder sequences.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: May 5, 2020
    Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
    Inventors: Ryan Bannen, Sarah Barilovits, Jigar Patel, Eric Sullivan, John Tan
  • Publication number: 20190366295
    Abstract: The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 5, 2019
    Inventors: Ryan Bannen, Sarah Barilovits, Jigar Patel, Eric Sullivan, John Tan
  • Patent number: 10427126
    Abstract: The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 1, 2019
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Ryan Bannen, Sarah Barilovits, Jigar Patel, Eric Sullivan, John Tan
  • Patent number: 10393751
    Abstract: The invention provides novel peptide binders for streptavidin (SA), Taq polymerase and several human proteins: Prostate Specific Antigen (PSA), thrombin, Tumor Necrosis Factor Alpha (TNF?), and Urokinase-type Plasminogen Activator (uPA).
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
    Inventors: Thomas Albert, Ryan Bannen, Victor Lyamichev, Jigar Patel, Eric Sullivan
  • Publication number: 20190205920
    Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.
    Type: Application
    Filed: August 11, 2017
    Publication date: July 4, 2019
    Applicant: THE TICKET FAIRY, INC.
    Inventors: Ritesh PATEL, Jigar PATEL
  • Publication number: 20190197571
    Abstract: The present technology generally relates to content distribution via a network of computing devices. The technology may include presenting online content to users via computer networks, such as the Internet and, more particularly, to methods and systems for establishing relationships between users wherein these relationships are employed to deliver content to users based, e.g., on potential interest in events. The present technology may additionally or alternately be employed, for example, to increase the distribution of content via a network of computing devices, to select and/or manage the presentation of content over the network of computing devices, and to select targets for the presentation of content over the network of computing devices.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 27, 2019
    Applicant: THE TICKET FAIRY, INC.
    Inventors: Ritesh PATEL, Jigar PATEL