Patents by Inventor Jih R. Hwu

Jih R. Hwu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photo-induced DNA-cleaving agents
    Patent number: 5527683
    Abstract: The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl)wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl); R.sub.2 is hydrogen; R.sub.3 is hydrogen or phenyl; R.sub.4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O.sub.2 to form HO. radicals under irradiation of UV light for a period of 2-3 hours. The HO. radicals then react with DNA to accomplish cleavage of DNA.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: June 18, 1996
    Assignee: National Science Council
    Inventors: Jih R. Hwu, Shwu-Chen Tsay, Buh-Luen Chen, Himatkumar V. Patel, Wan-Lin Chen, Chun C. Lin, Ching-Tai Chou
  • Prostanoids and synthesis thereof
    Patent number: 5013862
    Abstract: Prostaglandin analogues which include a bicyclic isoxazolidine nucleus are disclosed. These analogues may be used to prepare other prostaglandins. Essential to the synthesis is intramolecular nitrone-alkene cycloaddition involving an alkenyl nitrone in which the reacting centers are separated by two carbons.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: May 7, 1991
    Assignee: The Johns Hopkins University
    Inventors: Jih R. Hwu, Jeffrey A. Robl
  • Prostanoids and synthesis thereof
    Patent number: 4855437
    Abstract: Prostaglandin analogues which include a bicyclic isoxazolidine nucleus are disclosed. These analogues may be used to prepare other prostaglandins. Essential to the synthesis is intramolecular nitrone-alkene cycloaddition involving an alkenyl nitrone in which the reacting centers are separated by two carbons.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: August 8, 1989
    Assignee: The Johns Hopkins University
    Inventors: Jih R. Hwu, Jeffrey A. Robl