Abstract: A high-efficiency cultivation method for high-frequency drip irrigation, water saving, seedling survival and strengthening, and yield increase of cotton fields in saline-alkali soil is provided, belonging to the field of agricultural planting technologies. It mainly includes performing land preparation; setting a planting mode; laying tubes; performing a high frequency drip irrigation; fertilizing with water; performing intertillage; performing chemical control; and performing green prevention and control. The method effectively solves many defects in the existing methods, improves the quality of cotton field preparation and seeding in saline-alkali soil, saves irrigation water, increases the emergence rate and seedling survival rate, improves the saline-alkali resistance of cotton seedlings, increases the yield, and achieves the goal of water-saving, high-quality and high-efficiency cultivation of cotton seedlings in saline-alkali soil.