Patents by Inventor Jihong Lou

Jihong Lou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted imidazoles useful for treating type II diabetes
    Patent number: 8329920
    Abstract: The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: December 11, 2012
    Assignee: Pfizer Inc.
    Inventors: John William Benbow, Jihong Lou, Jeffrey Allen Pfefferkorn, Meihua Mike Tu
  • Fused phenyl amido heterocyclic compounds
    Patent number: 8119624
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: February 21, 2012
    Assignee: Pfizer Inc.
    Inventors: Hao Bai, Simon Bailey, Dilip Ramakant Bhumralkar, Feng C. Bi, Fengli Guo, Mingying He, Paul Stuart Humphries, Anthony Lai Ling, Jihong Lou, Seiji Nukui, Ru Zhou
  • Substituted Heteroaryls
    Publication number: 20110230445
    Abstract: The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 22, 2011
    Inventors: John William Benbow, Jihong Lou, Jeffrey Allen Pfefferkorn, Meihua Mike Tu
  • Substituted imidazole propanamide glucokinase activators
    Patent number: 7977367
    Abstract: The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: July 12, 2011
    Assignee: Pfizer Inc
    Inventors: John William Benbow, Jihong Lou, Jeffrey Allen Pfefferkorn, Meihua Mike Tu
  • Fluorinated Heteroaryls
    Publication number: 20110130365
    Abstract: The present invention provides Formula (1A) XN O R 3 HN R 5 O R 4 R 2 R 1 (1A) 5 compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the glucokinase enzyme, where X, R 1, R 2, R 3, R 4, and R 5 are as described herein.
    Type: Application
    Filed: July 15, 2009
    Publication date: June 2, 2011
    Inventors: John W. Benbow, Jihong Lou, Jeffrey A. Pferfferkorn, Meihua M. Tu
  • Fused Phenyl Amido Heterocyclic Compounds
    Publication number: 20110039821
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Inventors: Hao Bai, Simon Bailey, Dilip Ramakant Bhumralkar, Feng C. Bi, Fengli Guo, Mingying He, Paul Stuart Humphries, Anthony Lai Ling, Jihong Lou, Seiji Nukui, Ru Zhou
  • Fused phenyl amido heterocyclic compounds
    Patent number: 7842713
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: November 30, 2010
    Assignee: Pfizer Inc
    Inventors: Hao Bai, Simon Bailey, Dilip Ramakant Bhumralkar, Feng C. Bi, Fengli Guo, Mingying He, Paul Stuart Humphries, Anthony Lai Ling, Jihong Lou, Seiji Nukui, Ru Zhou
  • Substituted Heteroaryls
    Publication number: 20100063063
    Abstract: The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.
    Type: Application
    Filed: September 9, 2009
    Publication date: March 11, 2010
    Inventors: John William Benbow, Jihong Lou, Jeffrey Allen Pfefferkorn, Meihua Mike Tu
  • FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS
    Publication number: 20080280875
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
    Type: Application
    Filed: May 9, 2007
    Publication date: November 13, 2008
    Inventors: Hao Bai, Simon Bailey, Dilip Ramakant Bhumralkar, Feng C. Bi, Fengli Guo, Mingying He, Paul Stuart Humphries, Anthony Lai Ling, Jihong Lou, Seiji Nukul, Ru Zhou
  • Thienopyridine-phenylacetamides and their derivatives useful as new anti-angiogenic agents
    Patent number: 7208500
    Abstract: The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of X1–X5 and R1–R5 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: April 24, 2007
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Jihong Lou, Robert Steven Kania, Mingying He
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Patent number: 7045528
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: May 16, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, III, Ru Zhou
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20060079548
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: October 21, 2005
    Publication date: April 13, 2006
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Kania, Jihong Lou, Mingying He, Cynthia Palmer, William Romines, Ru Zhou
  • Inhibitors of SARS 3C like protease
    Publication number: 20060014821
    Abstract: The invention relates to methods of inhibiting SARS-related coronavirus viral replication activity comprising contacting a SARS-related coronavirus protease with a therapeutically effective amount of a SARS 3C like protease inhibitor, and compositions comprising the same.
    Type: Application
    Filed: August 13, 2004
    Publication date: January 19, 2006
    Inventors: Mingying He, Robert Kania, Jihong Lou, Simon Planken
  • Thienopyridine-phenylacetamides and their derivatives useful as new anti-angiogenic agents
    Publication number: 20050090509
    Abstract: The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of X1-X5 and R1-R5 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
    Type: Application
    Filed: August 26, 2004
    Publication date: April 28, 2005
    Inventors: Jihong Lou, Robert Kania, Mingying He
  • Napthalene carboxamides and their derivatives useful as new anti-angiogenic agents
    Publication number: 20050070508
    Abstract: The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of R1a-d, R2a-b, R3, and X1 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
    Type: Application
    Filed: August 23, 2004
    Publication date: March 31, 2005
    Inventors: Jihong Lou, Robert Kania, Mingying He, Ru Zhou
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Patent number: 6869962
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 22, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, III, Ru Zhou
  • Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use
    Patent number: 6833456
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R1 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: December 21, 2004
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: William Henry Romines, III, Robert Steven Kania, Jihong Lou, Stephan Cripps, Ru Zhou, Mingying He
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20040186126
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: March 9, 2004
    Publication date: September 23, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, Ru Zhou
  • Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use
    Publication number: 20040019065
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: February 21, 2003
    Publication date: January 29, 2004
    Inventors: William Henry Romines, Robert Steven Kania, Jihong Lou, Stephan Cripps, Ru Zhou, Mingying He
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20040009965
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: June 11, 2003
    Publication date: January 15, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, Ru Zhou