Abstract: Described herein is a method for separating antibody fragment impurities from target antibodies or desired fragments thereof.

Abstract: The invention provides a method for removing multimers from a preparation of recombinant polyclonal antibodies (rpAbs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers.

Abstract: Provided are methods of using ion exchange based chromatography to control the levels of high mannose glycoforms in a glycoprotein sample, such as an antibody sample. The high mannose glycoforms can be removed from the sample or isolated and enriched. Also provided is a composition comprising a glycoprotein, such as an antibody, from which the high mannose glycoforms have been reduced or removed or isolated or enriched using an ion exchange based chromatography step.

Abstract: A charging circuit and a control method thereof are disclosed, which are used for charging different brands of mobile devices. The charging circuit comprises: a universal interface (16) connected to a mobile device to be charged; a charging adaptation unit (14) comprising at least two types of charging circuits, wherein the charging adaptation unit (14) is connected to the universal interface (16) and configured to provide a corresponding charging circuit for the mobile device; a voltage conversion unit (10) connected to a charging power source and configured to adjust the output voltage of the charging power source to a charging voltage for the mobile device; and a current detection unit (12) connected between the voltage conversion unit (10) and the charging adaptation unit (14) and configured to detect a charging current, wherein the charging current is configured to determine the charging circuit corresponding to the mobile device.

Abstract: A system and method for processing data in chromatographic systems is described. In an implementation, the system and method includes processing data generated by a chromatographic system to generate processed data, analyzing the processed data, and preparing and providing results based on the processed data.

Abstract: A method for processing chromatographic peaks in chromatographic systems comprising comparing a first peak with a second peak; and determining whether the first peak and second peak should be grouped together.

Abstract: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.

Abstract: The disclosure discloses a method for power-on control of a mobile terminal and a mobile terminal. The method includes: when a power-on detection flag bit in a mobile terminal is at a high level, judging whether there is an external power supply access event; if it is judged that there is an external power supply access event, and it is detected that the mobile terminal is in a power-off status currently, then triggering an external power supply power-on event, and setting the power-on detection flag bit to a high level; if it is judged that there is no external power supply access event, then judging whether there is a key-pressing event; and if it is judged that there is a key-pressing event, and it is determined that the key-pressing event is used for controlling to turn on the mobile terminal, then triggering a key-pressing power-on event, and setting the power-on detection flag bit to a high level.

Abstract: A system and method for processing data in chromatographic systems is described. In an implementation, the system and method includes processing data generated by a chromatographic system to generate processed data, analyzing the processed data, and preparing and providing results based on the processed data.

Abstract: The present disclosure provides a management device for a charging circuit and a wireless terminal, which belong to the technical field of management control of a linear charging circuit. The device includes a power supply management module (5), a buck switching voltage converter (1) and a linear charging circuit (2). The power supply management module (5) includes an adjustable Low Dropout (LDO) linear regulator (6) and an Analog-to-Digital Converter (ADC) (4), wherein the output terminal of the adjustable LDO linear regulator (6) is connected with the feedback terminal of the buck switching voltage converter (1) through a first preset resistor (R62). The input terminal of the ADC (4) is connected with the anode of a battery (3). The control terminal of the power supply management module (5) is connected with the control terminal of the linear charging circuit (2). The output terminal of the buck switching voltage converter (1) is connected with the input terminal of the linear charging circuit (2).

Abstract: The present disclosure provides a management device for a charging circuit and a wireless terminal, which belong to the technical field of management control of a linear charging circuit. The device includes a power supply management module (5), a buck switching voltage converter (1) and a linear charging circuit (2). The power supply management module (5) includes an adjustable Low Dropout (LDO) linear regulator (6) and an Analog-to-Digital Converter (ADC) (4), wherein the output terminal of the adjustable LDO linear regulator (6) is connected with the feedback terminal of the buck switching voltage converter (1) through a first preset resistor (R62). The input terminal of the ADC (4) is connected with the anode of a battery (3). The control terminal of the power supply management module (5) is connected with the control terminal of the linear charging circuit (2). The output terminal of the buck switching voltage converter (1) is connected with the input terminal of the linear charging circuit (2).

Abstract: Disclosed are methods of purifying and analyzing cyclic peptide libraries using hydrophobic-hydrophobic interaction. An embodiment of the invention includes associating a hydrophobic tag, e.g., a fluorenylmethoxycarbonyl group (Fmoc), with non-cyclized linear peptide contaminants, followed by separation of the cyclic peptide library from the tagged linear peptide contaminants using a hydrophobic support such as a reversed phase chromatography column. Consequently, the cyclic peptide library is separated from the linear peptide contaminants since the linear peptide contaminants elute later from the support. Another aspect of the invention is directed to the analysis of the proportion of linear peptide contaminants in a cyclic peptide library. Also included within the scope of the invention are the compositions of matter which result from practicing methods of the invention.