Patents by Inventor Jikai Liu

Jikai Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligosaccharide Compound for Inhibiting Intrinsic Coagulation Factor X-Enzyme Complex, and Preparation Method Therefor and Uses Thereof
    Publication number: 20240041918
    Abstract: A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.
    Type: Application
    Filed: September 28, 2023
    Publication date: February 8, 2024
    Inventors: Jinhua ZHAO, Zhenguo Li, Na Gao, Mingyi Wu, Yanming Chen, Longyan Zhao, Yongsheng Wu, Zi Li, Chuang Xiao, Shunliang Zheng, Zhiyuan Nan, Jianbo Zhou, Jianping Xu, Lutan Zhou, Yafang Guo, Hongbo Qin, Jikai Liu
  • Oligosaccharide compound for inhibiting intrinsic coagulation factor X-enzyme complex, and preparation method therefor and uses thereof
    Patent number: 11833169
    Abstract: A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: December 5, 2023
    Assignees: MUDANJIANG YOUBO PHARMACEUTICAL CO., LTD., JIUZHITANG CO., LTD.
    Inventors: Jinhua Zhao, Zhenguo Li, Na Gao, Mingyi Wu, Yanming Chen, Longyan Zhao, Yongsheng Wu, Zi Li, Chuang Xiao, Shunliang Zheng, Zhiyuan Nan, Jianbo Zhou, Jianping Xu, Lutan Zhou, Yafang Guo, Hongbo Qin, Jikai Liu
  • OLIGOSACCHARIDE COMPOUND FOR INHIBITING INTRINSIC COAGULATION FACTOR X-ENZYME COMPLEX, AND PREPARATION METHOD THEREFOR AND USES THEREOF
    Publication number: 20200254003
    Abstract: A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.
    Type: Application
    Filed: January 10, 2017
    Publication date: August 13, 2020
    Inventors: Jinhua ZHAO, Zhenguo Li, Na Gao, Mingyi Wu, Yanming Chen, Longyan Zhao, Yongsheng Wu, Zi Li, Chuang Xiao, Shunliang Zheng, Zhiyuan Nan, Jianbo Zhou, Jianping Xu, Lutan Zhou, Yafang Guo, Hongbo Qin, Jikai Liu
  • Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof
    Patent number: 10689463
    Abstract: Disclosed are a Fuc3S4S substituted oligoglycosaminoglycan with a weight-average molecular weight (Mw) of about 4.5-9 kD, a pharmaceutical composition containing the Fuc3S4S substituted oligoglycosaminoglycan, a preparation method thereof and a use thereof in preparing medicines for preventing and/or treating thrombotic diseases.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 23, 2020
    Assignee: JIUZHITANG CO., LTD.
    Inventors: Jinhua Zhao, Jinxing He, Mingyi Wu, Zhiwen Liu, Na Gao, Longyan Zhao, Zi Li, Feng Lu, Li Xu, Chuang Xiao, Lian Yang, Jun Chen, Lutan Zhou, Wenlie Peng, Jikai Liu
  • Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof
    Patent number: 9896517
    Abstract: Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 20, 2018
    Assignee: Jiuzhitang Co., Ltd.
    Inventors: Jinhua Zhao, Jikai Liu, Mingyi Wu, Na Gao, Feng Lu, Zi Li
  • FUC3S4S SUBSTITUTED OLIGOGLYCOSAMINOGLYCAN AND PREPARATION METHOD THEREOF
    Publication number: 20160347868
    Abstract: Disclosed are a Fuc3S4S substituted oligoglycosaminoglycan with a weight-average molecular weight (Mw) of about 4.5-9 kD, a pharmaceutical composition containing the Fuc3S4S substituted oligoglycosaminoglycan, a preparation method thereof and a use thereof in preparing medicines for preventing and/or treating thrombotic diseases.
    Type: Application
    Filed: December 19, 2014
    Publication date: December 1, 2016
    Inventors: Jinhua ZHAO, Jinxing HE, Mingyi WU, Zhiwen LIU, Na GAO, Longyan ZHAO, Zi LI, Feng LU, Li XU, Chuang XIAO, Lian YANG, Jun CHEN, Lutan ZHOU, Wenlie PENG, Jikai LIU
  • LOW MOLECULAR WEIGHT GLYCOSAMINOGLYCAN DERIVATIVE, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20160039949
    Abstract: Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.
    Type: Application
    Filed: December 20, 2013
    Publication date: February 11, 2016
    Inventors: Jinhua ZHAO, Jikai LIU, Mingyi WU, Na GAO, Feng LU, Zi LI
  • Concentricolide and its derivatives, process for preparing them, pharmaceutical composition comprising the same and its use
    Patent number: 7659308
    Abstract: The present invention relates to concentricolide and its derivatives, a method for the preparation of the compound and its derivatives, a pharmaceutical composition containing concentricolide and its derivatives, and use of the compound and its derivatives for the treatment and prevention of infection caused by human immunodeficiency virus (HIV).
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: February 9, 2010
    Assignees: Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming Institute of Zoology, The Chinese Academy of Sciences
    Inventors: Jikai Liu, Yongtang Zheng, Xiangdong Qin, Liumeng Yang, Zejun Dong, Ruirui Wang, Jianwen Tan
  • Concentricolide and its derivatives, process for preparing them, pharmaceutical composition comprising the same and its use
    Publication number: 20070155830
    Abstract: The present invention relates to concentricolide and its derivatives, a method for the preparation of the compound and its derivatives, a pharmaceutical composition containing concentricolide and its derivatives, and use of the compound and its derivatives for the treatment and prevention of infection caused by human immunodeficiency virus (HIV).
    Type: Application
    Filed: October 20, 2004
    Publication date: July 5, 2007
    Applicants: Kunming Institute of Botany, The Chinese Academy o, Kunming Institute of Zoology, The Chinese Academy
    Inventors: Jikai Liu, Yongtang Zheng, Xiangdong Qin, Liumeng Yang, Zejun Dong, Ruirui Wang, Jianwen Tan