Patents by Inventor Jill D. Coursen

Jill D. Coursen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7438892
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: The United States of Americas as represented by the Secretary of the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jill D. Coursen, Qimin Zhan
  • Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7125850
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: October 24, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Sevices
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Methods for identifying inhibitors of GADD45 polypeptide activity and inhibitors of such activity
    Patent number: 7005419
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: February 28, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 6613318
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 2, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan