Patents by Inventor Jill Goldstein

Jill Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GDF11 VARIANTS AND USES THEREOF
    Publication number: 20240124542
    Abstract: Disclosed herein are GDF11 variant polypeptides. Also disclosed herein are methods for increasing GDF11 protein levels in a subject by administering a GDF11 variant polypeptide.
    Type: Application
    Filed: July 28, 2023
    Publication date: April 18, 2024
    Inventors: Amy J. Wagers, Jill Goldstein, Ryan G. Walker
  • GDF11 variants and uses thereof
    Patent number: 11725033
    Abstract: Disclosed herein are GDF11 variant polypeptides. Also disclosed herein are methods for increasing GDF11 protein levels in a subject by administering a GDF11 variant polypeptide.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: August 15, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Amy J. Wagers, Jill Goldstein, Ryan G. Walker
  • IN SITU GENE EDITING
    Publication number: 20210180087
    Abstract: Disclosed are methods of in situ genomic modification of cells (e.g., stem cells, tissue stem cells, muscle stem cells, Sca-V mesenchymal progenitor cells in skeletal muscle, CD140a+ dermal mesenchymal cells) using sequence-targeting nucleases delivered via a virus (e.g., an AAV).
    Type: Application
    Filed: August 19, 2019
    Publication date: June 17, 2021
    Inventors: Amy J. Wagers, Jill Goldstein, Leo Wang, Ya-Chieh Hsu, Meryem Gonzalez Celeiro
  • GDF11 VARIANTS AND USES THEREOF
    Publication number: 20210101951
    Abstract: Disclosed herein are GDF11 variant polypeptides. Also disclosed herein are methods for increasing GDF11 protein levels in a subject by administering a GDF11 variant polypeptide.
    Type: Application
    Filed: July 20, 2020
    Publication date: April 8, 2021
    Inventors: Amy J. Wagers, Jill Goldstein, Ryan G. Walker
  • IN VIVO GENE EDITING OF BLOOD PROGENITORS
    Publication number: 20200392533
    Abstract: Disclosed are methods of modifying the genome of HSPCs in vivo by introducing an AAV into a subject transducing a sequence targeting nuclease. In some aspects, the method can be utilized to ascertain causal links between CHIP mutations and age-associated disease. In other aspects, the method can be utilized to treat Sickle cell disease (SCD) and ?-thalassemia.
    Type: Application
    Filed: April 11, 2018
    Publication date: December 17, 2020
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Amy J. Wagers, Leo Wang, Jill Goldstein