Patents by Inventor Jill M. Bensie

Jill M. Bensie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acid substituted 4-aminophenazones for measuring enzyme activity
    Patent number: 5116730
    Abstract: Novel substrates which are amino acid 4-amino phenazones for detecting enzymes, particularly L-gamma-glutamyltransferase, are described. The amino acid gamma-glutamyl-4-aminophenazone reacts with the enzyme to produce 4-aminophenazone which is an amino dye intermediate. The amino dye intermediate is coupled with a second dye intermediate to form a chromogen. The 4-aminophenazone is particularly reacted with a phenolic naphtholic or aniline compound, particularly the phenolic compound 2-hydroxy-3,5-dichlorobenzenesulfonate, to form a red chromogen in the presence of an oxidizing agent, such as bilirubin oxidase.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: May 26, 1992
    Assignee: Board of Governors of Wayne State University
    Inventors: Joseph D. Artiss, Jill M. Bensie, Bennie Zak, Daniel S. Raden
  • Novel amino acid substituted 4-aminophenazones for measuring enzyme activity
    Patent number: 5081259
    Abstract: Novel substrates which are amino acid 4-amino phenazones for detecting enzymes, particularly L-gamma-glutamyltransferase, are described. The amino acid gamma-glutamyl-4-aminophenazone reacts with the enzyme to produce 4-aminophenazone which is an amino dye intermediate. The amino dye intermediate is coupled with a second dye intermediate to form a chromogen. The 4-aminophenazone is particularly reacted with a phenolic naphtholic or aniline compound, particularly the phenolic compound 2-hydroxy-3,5-dichlorobenzenesulfonate, to form a red chromogen in the presence of an oxidizing agent, such as bilrubin oxidase.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: January 14, 1992
    Assignees: Abbott Laboratories, Board of Governors of Wayne State University
    Inventors: Joseph D. Artiss, Jill M. Bensie, Bennie Zak, Daniel S. Raden