Patents by Inventor Jill M. Kolesar

Jill M. Kolesar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Direct detection and mutation analysis of low copy number nucleic acids
    Patent number: 6261781
    Abstract: A direct detection and quantitation of RNA or DNA contained in a sample is obtained by capillary electrophoresis of the RNA or DNA hybridized to a DNA or RNA probe of complementary sequence stabilized by the combination of a fluorophore terminally conjugated to the probe and a dye intercalating the RNA-DNA or DNA-DNA hybrid so formed. The RNA or DNA is quantified by measuring the total fluorescence emitted by the electrophoresed hybrid upon excitation by a laser generated light beam.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: July 17, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Jill M. Kolesar
  • Direct quantitation of low copy number RNA
    Patent number: 6013442
    Abstract: A direct quantitation of RNA contained in a sample is obtained by capillary electrophoresis of the RNA hybridized to a DNA probe of complementary sequence stabilized by the combination of a fluorophore terminally conjugated to the DNA probe and a dye intercalating the RNA-DNA hybrid so formed. The RNA is quantified by measuring the total fluorescence emitted by the electrophoresed hybrid upon excitation by a laser generated light beam.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: January 11, 2000
    Inventors: Jill M. Kolesar, Peter G. Allen