Patents by Inventor Jill M. Kolesar

Jill M. Kolesar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240228580
    Abstract: An antigen-presenting dendritic cell membrane derived nanovesicle (CDNV) can be made by incubating a dendritic cell (DC) with an antigen and an agent to activate the DC, thereby generating a mature DC displaying a major histocompatibility complex class I (MHC) presenting the antigen, and fragmenting the membrane of the mature DC and allowing the fragmented membrane to assemble into a CDNV displaying the MHC presenting the antigen. The CDNV can be delivered to an environment including a T cell, thereby directly activating the T cell, or indirectly activating the T cell through a bystander antigen presenting cell (APC) that uptakes the CDNV and presents the antigen. The activated T cell and produce a T cell response.
    Type: Application
    Filed: January 5, 2024
    Publication date: July 11, 2024
    Inventors: Jill M. Kolesar, Christopher I. Richards
  • Patent number: 6261781
    Abstract: A direct detection and quantitation of RNA or DNA contained in a sample is obtained by capillary electrophoresis of the RNA or DNA hybridized to a DNA or RNA probe of complementary sequence stabilized by the combination of a fluorophore terminally conjugated to the probe and a dye intercalating the RNA-DNA or DNA-DNA hybrid so formed. The RNA or DNA is quantified by measuring the total fluorescence emitted by the electrophoresed hybrid upon excitation by a laser generated light beam.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: July 17, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Jill M. Kolesar
  • Patent number: 6013442
    Abstract: A direct quantitation of RNA contained in a sample is obtained by capillary electrophoresis of the RNA hybridized to a DNA probe of complementary sequence stabilized by the combination of a fluorophore terminally conjugated to the DNA probe and a dye intercalating the RNA-DNA hybrid so formed. The RNA is quantified by measuring the total fluorescence emitted by the electrophoresed hybrid upon excitation by a laser generated light beam.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: January 11, 2000
    Inventors: Jill M. Kolesar, Peter G. Allen