Abstract: The disclosure provides methods for treating muscular dystrophy (MD), such as Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) in a mammalian subject. The methods are particularly useful for treating, inhibiting, reducing, ameliorating or delaying the onset of hypertrophic cardiomyopathy, dilated cardiomyopathy, heart failure and/or cardiac fibrosis in subjects diagnosed with, and/or being treated for, MD.The methods comprise administering to the subject an effective amount of a peptide such as H-D-Arg-2,6-Dmt-Lys-PHe-NH2 (a.k.a. elamipretide), or a pharmaceutically acceptable salt, hydrate, solvate and/or tautomer thereof, optionally in combination with at least one other active ingredient (i.e. drug) such a corticosteroid, ACE inhibitor, ARB(s), beta-blocker or drug that increases or corrects the expression of dystrophin in the subject (e.g. Eteplirsen (Exondys 51®), Golodirsen (Vyondys 53™)) or Casimersen (Amondys 45™).

Abstract: Embodiments of the invention propose volt/VAR optimization that may be time synchronized and automated based on actions invoked at a control system utilizing a smart grid solution that incorporates metering end points which are capable of reporting to a utility the information that is needed by the utility or to another system for making real time decisions on events that may occur at the distribution level. Embodiments of the invention incorporate large numbers of end points (e.g., smart meters) which a utility can use to determine how any event or events it may invoke at the grid level affect its compliance at the end user level.

Abstract: Embodiments of the invention propose volt/VAR optimization that may be time synchronized and automated based on actions invoked at a control system utilizing a smart grid solution that incorporates metering end points which are capable of reporting to a utility the information that is needed by the utility or to another system for making real time decisions on events that may occur at the distribution level. Embodiments of the invention incorporate large numbers of end points (e.g., smart meters) which a utility can use to determine how any event or events it may invoke at the grid level affect its compliance at the end user level.

Abstract: Methods and systems are provided for synchronizing meter clocks in both basic residential meters and in advanced and C&I meters with advanced communication modules. The synchronization methods and systems provide easy-to-manage solutions from the head end, without impacting billing data.

Abstract: An apparatus for providing zonal isolation in a wellbore includes a plurality of interlocking sealing elements having anchor elements at the opposing ends. Each anchor element sealingly engages a wellbore tubular whereas the interlocking sealing elements do not engage any portion of wellbore therebetween. In one exemplary application utilizes a wellhead and lubricator positioned over a wellbore under pressure and a conveyance device for conveying equipment into the wellhead. The first anchor, the second anchor and the plurality of interlocking sealing elements are separately conveyed into the wellbore with the conveyance device and sequentially assembled in the wellbore to provide zonal isolation.