Patents by Inventor Jim D. Durbin

Jim D. Durbin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for crystallizing human beta secretase in complex with an inhibitor
    Patent number: 7806980
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: October 5, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • Crystallization and Structure Determination of Glycosylated Human Beta Secretase, an Enzyme Implicated in Alzheimer's Disease
    Publication number: 20100112665
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Application
    Filed: September 2, 2009
    Publication date: May 6, 2010
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
    Patent number: 7601528
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: October 13, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
    Publication number: 20090125289
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three-dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Application
    Filed: May 14, 2007
    Publication date: May 14, 2009
    Inventors: Timothy E. Benson, Jim D. Durbin, Donald Bryan Prince
  • Crystallization and structure determination of beta secretase and/or beta secretase-like proteins
    Publication number: 20080215249
    Abstract: The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.
    Type: Application
    Filed: April 16, 2008
    Publication date: September 4, 2008
    Inventors: Timothy E. Benson, Jim D. Durbin, Thomas L. Emmons, Alfredo G. Tomasselli
  • Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
    Patent number: 7384773
    Abstract: The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: June 10, 2008
    Assignee: Pfizer Inc
    Inventors: Timothy E. Benson, Jim D. Durbin, Thomas L. Emmons, Alfredo G. Tomasselli
  • Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
    Patent number: 7217556
    Abstract: The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: May 15, 2007
    Assignee: Pfizer Inc
    Inventors: Timothy E. Benson, Jim D. Durbin, Donald Bryan Prince