Abstract: The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

Abstract: The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

Abstract: The specification relates to a jewelry setting. The jewelry setting includes a gemstone having a culet; a mounting rod having a culet-shaped indent; and at least one braze joint, the at least one braze joint being formed between the culet and the culet-shaped indent.

Abstract: The specification relates to a jewelry setting. The jewelry setting includes a gemstone having a culet; a mounting rod having a culet-shaped indent; and at least one braze joint, the at least one braze joint being formed between the culet and the culet-shaped indent.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: The specification relates to a gemstone setting. The gemstone setting includes a gemstone, a mounting surface and a braze joint. The braze joint is formed from a reactive metallic alloy with the reactive metallic alloy adhering the gemstone to the mounting surface. The braze joint is substantially concealed from a direct line of sight from a top portion of the gemstone by preventing excessive alloy from getting outside a desired braze area.

Abstract: A control mechanism pins an optical fiber assembly on and off gimbal and between gimbals to route the assembly from an off-gimbal optical source across the gimbal axis/axes to an on-gimbal optical element so that the fiber assembly moves with the rotation of the gimbals. To accommodate a relatively large range of motion, the control mechanism is suitably configured to route the fiber assembly in a “U-shaped” loop with one end pinned off-gimbal in a stationary guide track and the other end pinned on-gimbal point in a rotating guide track so that the loose fiber assembly is constrained in the concentric tracks on and off gimbal. As the gimbal rotates, the loop seats onto one guiding track and peels off of the other guiding track while always maintaining its U shape.