Abstract: Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the present composition in the treatment of various disorders.

Abstract: A hinge for pivotably mounting a panel to a vehicle body includes a panel attachment plate securable to the panel, a body attachment plate securable to the vehicle body, and an intermediate member pivotably attached between the body and panel attachment plates. The intermediate member has opposite sidewalls and a center flange extending between the sidewalls. The sidewalls engage the body attachment plate with the center flange spaced from the body attachment plate when the intermediate member is pivoted such that the sidewalls are positioned generally along the body attachment plate. The intermediate member may include a stop member for limiting pivotal movement of the panel attachment plate. The stop member may limit such pivotal movement at different positions by being cut to different sizes during manufacture of the hinge. The body attachment plate may provide a hinge portion that provides enhanced structural rigidity to the hinge.