Patents by Inventor Jimin Xu

Jimin Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections
    Patent number: 11767303
    Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: September 26, 2023
    Assignees: HEALTH RESEARCH, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Hongmin Li, Zhong Li, Jia Zhou, Jimin Xu, Qing-Yu Zhang
  • COMPOSITIONS, METHODS OF TREATING AND PREVENTING FUNGAL INFECTIONS, AND METHODS OF INHIBITING PRP8 INTEIN EXPRESSION
    Publication number: 20230233533
    Abstract: The present disclosure relates to a Prp8 intein splicing inhibitor. The present disclosure further relates to a method of treating and/or preventing a fungal infection, said method comprising administering a Prp8 intein splicing inhibitor under conditions effective to treat and/or prevent a fungal infection. Also disclosed is a method of inhibiting Prp8 intein expression or activity in a cell or tissue, said method comprising administering a compound under conditions effective to inhibit Prp8 intein expression or activity in a cell or tissue. Further disclosed are methods for screening for compounds that inhibit Prp8 intein splicing comprising an assay and a kit for predicting the likelihood of Prp8 inhibition.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 27, 2023
    Applicants: Health Research, Inc., The Board of Regents of the University of Texas System
    Inventors: Hongmin LI, Zhong LI, Jia ZHOU, Jimin XU
  • SALICYLAMIDE DERIVATIVES AND RELATED METHODS OF MAKING
    Publication number: 20230140290
    Abstract: Certain embodiments describe antiviral compounds and related methods of using such compounds.
    Type: Application
    Filed: January 26, 2021
    Publication date: May 4, 2023
    Inventors: Jia ZHOU, Jimin XU, Javier SANCHEZ-CESPEDES, Judith BERASTEGUI-CABRERA, Maria Eugenia PACHON-IBANEZ, Jeronimo PACHON-DIAZ
  • SUBSTITUTED 4,6-DIHYDROSPIRO[[1,2,3]TRIAZOLO[4,5-B]PYRIDINE-7,3'-INDOLINE]-2',5(3H)-DIONE ANALOGUES
    Publication number: 20230056205
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Application
    Filed: July 1, 2022
    Publication date: February 23, 2023
    Applicants: The Board of Regents of The University of Texas System, The Board of Regents of The University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie
  • Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues
    Patent number: 11407752
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie
  • COMPOUNDS AND METHODS FOR INHIBITING VIRAL REPLICATION AND METHODS OF TREATING AND PREVENTING FLAVIVIRAL INFECTIONS
    Publication number: 20220024884
    Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.
    Type: Application
    Filed: July 23, 2021
    Publication date: January 27, 2022
    Inventors: Hongmin LI, Zhong LI, Jia ZHOU, Jimin XU, Qing-Yu ZHANG
  • SUBSTITUTED 4,6-DIHYDROSPIRO[[1,2,3]TRIAZOLO[4,5-B]PYRIDINE-7,3'-INDOLINE]-2',5(3H)-DIONE ANALOGUES
    Publication number: 20210047329
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: February 18, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie