Abstract: Provided are a silicon negative electrode material, which is characterized by comprising silicon particles and carbon nanotubes grown on the surface of the silicon particles, wherein the carbon nanotubes comprise fluffy carbon nanotubes and intertwined filamentary carbon nanotubes, and the silicon particles are wrapped by the fluffy carbon nanotubes and the filamentary carbon nanotubes. Further provided is a method for preparing the silicon negative electrode material.

Abstract: A composition comprising dichloroacetic acid and glyoxylic acid, wherein, the content of glyoxylic acid is below 1000 pm, and the preparation method and application of the composition. A process for preparing the composition, comprising: mixing a dichloroacetic acid material having greater than 1000 ppm glyoxylic acid with a glyoxylic acid capture reagent, and a process for preparing oligonucleotides, comprising using the composition. It is found that glyoxylic acid is an impurity in commercially available DCA products, which may cause the oligonucleotides synthesis failure. Ion chromatography can be used to detect glyoxylic acid in dichloroacetic acid and accurately determine its concentration.

Abstract: Disclosed is a composition comprising dichloroacetic acid, a process for preparing the same and a use thereof. It has been discovered that the novel impurity is glyoxylic acid, and glyoxylic acid in dichloroacetic acid can be detected and its concentration accurately measured, by ion chromatography method.

Abstract: A silicon-containing negative electrode active material may include a silicon-based material and a conductive layer, located on the surface of the silicon-based material, including a polymer and a one-dimension conductive material, wherein, the polymer may include polar functional group(s) including one or more selected form carboxylic acid group, hydroxyl group, amide groups, amino group, carbonyl group, and nitro group; and the polar functional group(s) in the polymer may have a mass percentage content as A1, and silicon in the silicon-based material may have a mass percentage content as A2, the silicon-containing negative electrode active material may satisfy: A2 is from 5% to 100% and A2/A1 is from 0.2 to 8.

Abstract: Disclosed are processes for preparing oligonucleotides. The process comprises: (a) converting a compound of Formula X-1 into a compound of Formula X-2: where R10 is a residue of an oligonucleotide (e.g., a phosphorodiamidate morpholino oligomer); R11 is an amine protecting group; wherein the compound of Formula X-1 is not bound to a solid support; and; (b) optionally removing protecting groups in the compound of Formula X-2 to obtain the olignucleotide. The synthetic processes described herein are advantageous in many aspects, including but not limited to improved yields and purities of target phosphorodiamidate morpholino oligomers with reduced 4-nitrostyrene adduct impurities.

Abstract: Disclosed is a composition comprising dichloroacetic acid, a process for preparing the same and a use thereof. It has been discovered that the novel impurity is glyoxylic acid, and glyoxylic acid in dichloroacetic acid can be detected and its concentration accurately measured, by ion chromatography method.

Abstract: The invention herein describes a solid-phase synthetic method for preparing thiolated oligonucleotides without needing a capping step. The methods of the invention comprises repetition of a three-reaction per cycle, namely detritylation, coupling and sulfurization, without a capping step. In some embodiments, the synthetic methods of the present invention can be used for preparing an anti-sense oligonucleotide.

Abstract: The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the unreacted 5?-OH groups.