Patents by Inventor Jimin Zhang

Jimin Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10525083
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 7, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Barbara Brannetti, Jennifer Brogdon, Boris Engels, Brian Granda, Lu Huang, Ming Lei, Na Li, Jimin Zhang, Carla Guimaraes
  • Publication number: 20190389028
    Abstract: A method of chemical mechanical polishing includes bringing a substrate having a conductive layer disposed over a semiconductor wafer into contact with a polishing pad, generating relative motion between the substrate and the polishing pad, monitoring the substrate with an in-situ electromagnetic induction monitoring system as the conductive layer is polished to generate a sequence of signal values that depend on a thickness of the conductive layer, determining a sequence of thickness values for the conductive layer based on the sequence of signal values, and at least partially compensating for a contribution of conductivity of the semiconductor wafer to the signal values.
    Type: Application
    Filed: June 13, 2019
    Publication date: December 26, 2019
    Inventors: Wei Lu, David Maxwell Gage, Harry Q. Lee, Kun Xu, Jimin Zhang
  • Patent number: 10464184
    Abstract: Before a first surface of a substrate is polished using a chemical mechanical process, the substrate is transferred to a modification station. The substrate comprises a side wall connected with the first surface at an edge and a second surface opposite to the first surface and also connected to the side wall. The first surface is substantially flat. The side wall is substantially perpendicular to the first surface. The edge of the substrate is modified at the modification station by removing material from a region of the first surface. The side wall of the substrate is a boundary of the region. The modified edge comprises a modified first surface that tapers within the region towards the second surface. The side wall remains substantially perpendicular to the first surface.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 5, 2019
    Assignee: Applied Materials, Inc.
    Inventors: Jimin Zhang, Zhihong Wang, Wen-Chiang Tu
  • Publication number: 20190292238
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
    Type: Application
    Filed: January 24, 2019
    Publication date: September 26, 2019
    Inventors: Hans Bitter, Jennifer Mary Bordeaux, Barbara Brannetti, Jennifer Brogdon, Naveen Kumar Dakappagari, Saar Gill, Steven Highfill, Lu Huang, Carl H. June, Ju Young Kim, Ming Lei, Na Li, Andreas Loew, Elena Orlando, Marco Ruella, Thai Tran, Jimin Zhang, Li Zhou
  • Publication number: 20190262170
    Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a dry eye condition of the individual, includes: a housing; a member having a first portion accommodated in the housing, and a second portion that is moveable relative to the housing, wherein the second portion is for placement outside the individual, and is configured to oscillate to apply the mechanical vibration to the body portion, the member having an elongated configuration; and a motor in the housing, the motor configured to oscillate the member at an oscillation frequency sufficient to induce tear production when the second portion of the member is applied towards a surface of the body portion.
    Type: Application
    Filed: August 7, 2018
    Publication date: August 29, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Publication number: 20190262171
    Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a dry eye condition of the individual, includes: a housing; a member having a first portion accommodated in the housing, and a second portion that is moveable relative to the housing, wherein the second portion is for placement outside the individual, and is configured to oscillate to apply the mechanical vibration to the body portion; and a motor in the housing, the motor configured to cause the member to undergo bending action in a reciprocating manner to oscillate the second portion of the member at an oscillation frequency sufficient to induce tear production when the second portion of the member is applied towards a surface of the body portion.
    Type: Application
    Filed: August 7, 2018
    Publication date: August 29, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Publication number: 20190262172
    Abstract: A method to treat a dry eye condition of an individual, includes: receiving a switch signal generated based on a manipulation of a control switch at a handheld device; and activating a motor in response to the switch signal to oscillate a member at an oscillation frequency, the member having an elongated configuration, and having a portion for placement outside the individual; wherein the oscillation frequency is sufficient to induce tear production when the portion of the member is applied towards a surface of a body portion of the individual.
    Type: Application
    Filed: August 7, 2018
    Publication date: August 29, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Publication number: 20190262225
    Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a condition of the individual, includes: a housing; a cantilever beam having a first portion accommodated in the housing, and a second portion that is moveable relative to the housing, wherein the second portion is configured to apply the mechanical vibration to the body portion; and a motor in the housing, the motor configured to oscillate the second portion of the cantilever beam at an oscillation frequency.
    Type: Application
    Filed: August 7, 2018
    Publication date: August 29, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Publication number: 20190262173
    Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a condition of the individual, includes: a housing; a member having a portion that is moveable relative to the housing, wherein the portion of the member is configured to oscillate to apply the mechanical vibration to the body portion, the member having an elongated configuration; and a motor having a weight that is supported by the member.
    Type: Application
    Filed: August 7, 2018
    Publication date: August 29, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Publication number: 20190247400
    Abstract: The present disclosure relates to methods for treating an ANCA associated vasculitis, for example, granulomatosis with polyangiitis (GPA), with compositions comprising an effective amount of certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds of Formula (I), including pharmaceutically acceptable salts thereof, that inhibit dipeptidyl peptidase 1 (DPP1) activity. In one embodiment, the compound of Formula (I) is (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (INS1007).
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Keith DIPETRILLO, Carlos FERNANDEZ, Jimin ZHANG
  • Publication number: 20190232091
    Abstract: Methods and devices are described which allow sound waves to be safely be applied to the eyelid of an eye of a patient or through the eyelid to other structures in the eye or to or through structures in the facial region to effect changes to one or more structures in and around the eye or directly through the cornea or sclera to regions of the eye to treat one or more diseases of the eye.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 1, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Eric Gertner, Jimin Zhang
  • Patent number: 10350723
    Abstract: During polishing of a substrate a first signal is received from a first in-situ monitoring system and a second signal is received from a second in-situ monitoring system. A clearance time at which a conductive layer is cleared and a top surface of an underlying dielectric layer of the substrate exposed and determine based on the first signal. An initial value of the second signal at the determined clearance time is determined. An offset is added to the initial value to generate a threshold value, and a polishing endpoint is triggered when the second signal crosses the threshold value.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: July 16, 2019
    Assignee: Applied Materials, Inc.
    Inventors: Shih-Haur Shen, Jianshe Tang, Jimin Zhang, David Maxwell Gage
  • Patent number: 10303691
    Abstract: Embodiments of the present invention provide a column-oriented database processing method, where a column-oriented database includes a marker column and more than one data column, the data column is used to store specific data in a column store manner, a value of a marker bit of each row in the marker column is used to indicate validity of data that is located in a same row as the marker bit, and the method includes: receiving a query request sent by an application program, where the query request contains a query condition; querying the more than one data column according to the marker column and the query condition to obtain a query result that meets both the query condition and a requirement that a marker bit of the query result in the marker column is valid; and sending the query result to the application program.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: May 28, 2019
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Jimin Wu, Qing Zhang, Chenghua Liu, Yong Deng
  • Patent number: 10253086
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: April 9, 2019
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Hans Bitter, Jennifer Mary Bordeaux, Barbara Brannetti, Jennifer Brogdon, Naveen Kumar Dakappagari, Saar Gill, Steven Highfill, Lu Huang, Carl H. June, Ju Young Kim, Ming Lei, Na Li, Andreas Loew, Elena Orlando, Marco Ruella, Thai Tran, Jimin Zhang, Li Zhou
  • Publication number: 20190084119
    Abstract: A method of controlling polishing includes sweeping a sensor of an in-situ monitoring system across a substrate as a layer of the substrate undergoes polishing, generating from the in-situ monitoring system a sequence of signal values that depend on a thickness of the layer, detecting from the sequence of signal values, a time that the sensor traverses a leading edge of the substrate or a retaining ring and a time that the sensor traverses a trailing edge of the substrate or retaining ring; and for each signal value of at least some of the sequence of signal values, determining a position on the substrate for the signal value based on the time that the sensor traverses the leading edge and the time that the sensor traverses a trailing edge.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 21, 2019
    Inventors: Harry Q. Lee, Kun Xu, Jimin Zhang
  • Publication number: 20190070069
    Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a condition of the individual, includes: a housing; a member having an exterior surface for contacting the individual, the member configured to oscillate to apply the mechanical vibration to the body portion; and a motor in the housing, the motor configured to cause the member to oscillate at an oscillation frequency for inducing tear production or a sinus effect; wherein the handheld device has an operational sound level that is 40 dB or less.
    Type: Application
    Filed: August 7, 2018
    Publication date: March 7, 2019
    Applicant: Olympic Ophthalmics, Inc.
    Inventors: Michael Gertner, Jimin Zhang, Arash Sabet
  • Patent number: 10076817
    Abstract: A chemical mechanical polishing apparatus includes a plate on which a substrate is received, and a movable polishing pad support and coupled polishing pad which move across the substrate and orbit a local region of the substrate during polishing operation. The load of the pad against the substrate, the revolution rate of the pad, and the size, shape, and composition of the pad, may be varied to control the rate of material removed by the pad.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: September 18, 2018
    Assignee: Applied Materials, Inc.
    Inventors: Hung Chih Chen, Paul D. Butterfield, Jay Gurusamy, Jason Garcheung Fung, Shou-Sung Chang, Jimin Zhang, Eric Lau
  • Publication number: 20180207044
    Abstract: An integrated patient platform system and method for performing medical procedures below a patient's body is disclosed. In some embodiments, a superior level surface of an integrated patient platform is configured to support a patient lying in a prone or supine position, and an inferior level surface of the integrated patient platform is configured to support one or more medical procedure components. The superior level surface includes an aperture disposed therethrough. At least a portion of the aperture forms an examination window that is adjustable in size and position and configured to receive a portion of a patient over or in the examination window. A medical procedure component may be positioned on the inferior level surface to contact or otherwise interface with the portion of the patient positioned over or in the examination window.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 26, 2018
    Applicant: Kona Medical, Inc.
    Inventors: Arash Sabet, David M. Perozek, Michael Gertner, Jimin Zhang
  • Publication number: 20180200186
    Abstract: Compositions comprising an RNA interference (RNAi) compound complexed to or encapsulated by lipid particles are provided. The lipid particle is a lipid nanoparticle, a liposome or a combination thereof. The lipid particle comprises a cationic lipid, a phospholipid, a sterol or a tocopherol or a derivative thereof, and a conjugated lipid. The invention also provides methods for treating pulmonary diseases or disorders such as pulmonary fibrosis and sarcoidosis using the compositions comprising the RNAi-lipid particles of the invention. The methods comprise administering one or more of the RNAi compositions to the lungs of the patient in need thereof via an inhalation delivery device, for example, a nebulizer, dry powder inhaler, or a metered dose inhaler.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 19, 2018
    Inventors: Kuan-Ju CHEN, Franziska LEIFER, Vladimir MALININ, Walter PERKINS, Jimin ZHANG, Keith DIPETRILLO
  • Publication number: 20180125892
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 10, 2018
    Inventors: Barbara Brannetti, Jennifer Brogdon, Boris Engels, Brian Granda, Lu Huang, Ming Lei, Na Li, Jimin Zhang, Carla Patricia Pinto Guimaraes