Abstract: Provided are a class of compounds, a stereoisomer, an optical isomer, a pharmaceutically acceptable salt, a prodrug, a solvate (for example, a hydrate) or an isotope derivative thereof. The compounds have a tri-heterocyclic structure (for example, the structure represented by formula (A)), which is a novel structure, thereby providing a new direction for the development of SOS1 inhibitor drugs. In-vitro enzyme activity inhibition activity studies show that the compounds have a relatively strong inhibition effect on SOS1 and can be used as a prospective compound for preventing and/or treating SOS1-mediated diseases. Moreover, said compounds also exhibit significant inhibitory activity on NCI-H358 cell proliferation. Furthermore, a specific synthesis method is provided. The synthesis method is simple in process, convenient to operate and beneficial to large-scale industrial production and use.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive, from a high speed train (HST) cell, a system information block (SIB) indicating an HST flag based at least in part on the UE camping on the HST cell. The UE may disconnect from the HST cell and camping on a non-HST cell based at least in part on a UE mobility in an HST railway. The UE may determine that disconnecting from the non-HST cell and camping on a new HST cell is to be prioritized over remaining on the non-HST cell, based at least in part on the UE being in the HST railway and based at least in part on a priority of HST cells being greater than a priority of non-HST cells. Numerous other aspects are described.

Abstract: A method for constructing a micro-nano porous organic acid pretreatment layer on the metal surface and its application are provided. A pretreatment reagent used is prepared by chemically grafting organic acid with hydroxylation-rich polymer. After immersed in the pretreatment reagent for a period of time, the metal substrates are then dried and cured, and the organic acid pretreatment layer with a micro-nano porous structure and excellent adhesion is successfully formed. The present invention provides the pretreatment reagent and pretreatment process of the metal surface coating protection technology. The solvent is only pure water and realizes no organic solvation. The pretreatment layer has excellent adhesion with the metal substrate, rough and porous structure, and can be closely interlocked with the subsequent coating layer, which greatly enhances the anticorrosion performance of the whole coating system.