Patents by Inventor Jiming Ye

Jiming Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8722634
    Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: May 13, 2014
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
    Inventors: Yang Ye, Minjia Tan, Changqiang Ke, Tong Chen, Xiqiang Li, Edward Kraegen, Jiming Ye, David James, Gregory Cooney
  • Publication number: 20110152208
    Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
    Type: Application
    Filed: January 14, 2009
    Publication date: June 23, 2011
    Applicants: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
    Inventors: Yang Ye, David E. James, Minjia Tan, Gregory J. Cooney, Changqiang Ke, Edward W. Kraegen, Tong Chen, Jiming Ye, Xiqiang Li
  • Publication number: 20100113494
    Abstract: The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
    Type: Application
    Filed: September 30, 2007
    Publication date: May 6, 2010
    Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Lihong Hu, Jia Li, Jingya Li, Hankun Zhang, Zhe Cheng, Jiming Ye, David E. James, Edward W. Kraegen