Abstract: The present invention provides for compositions or formulations including a curcuminoid and at least one of resveratrol, resveratrol derivative, catechin, or catechin derivative. The present invention also provides for a method of treating any disease where uncontrolled cellular proliferation occurs, such as cancers. In particular, the present invention provides a method for treating cervical cancer and precancerous cervical lesions. The present invention also provides methods to treat viral infections. The disclosed compositions or formulations are biologically more active demonstrating strong synergy, functions to activate multiple novel genes. The disclosure further shows that the composition increases cellular uptake of curcumin and are able to stabilize curcumin in an aqueous environment. All these enhanced properties are accomplished by a composition or formulation that is much simpler to manufacture and lower in cost.