Abstract: An ablation probe (1; 100; 200), comprising: an applicator (2; 102; 202) arranged to apply radiation to heat surrounding tissue; a feeding cable (4; 104; 204) arranged to supply electromagnetic energy to the applicator. The feeding cable comprises a distal portion (2a, 202a) and a proximal portion (2b; 202b). The distal portion of the feeding cable has a distal cross sectional size and the proximal portion of the feeding cable has a proximal cross sectional size, wherein the distal cross sectional size is less that the proximal cross sectional size. The ablation probe further comprises a connector (24; 224) arranged to mechanically and electrically couple the distal portion (2a, 202a) of the feeding cable (2; 202) to the proximal portion (2b; 202b) of the feeding cable (2; 202).

Abstract: An ablation probe (100; 200) suitable for insertion through the working channel of an intraluminal delivery device comprises an applicator (102; 202) arranged to apply radiation to heat surrounding tissue. The probe also comprises a feeding cable (104; 204) arranged to supply electromagnetic energy to the applicator (102; 202). The probe further comprises a first coolant flow path (106). There is also a deformable member (110; 210) arranged to move between an insertion configuration in which insertion of the probe is facilitated and a deployed configuration. A second coolant path (108), via which coolant is able to flow, is provided by the deformable member (110; 210) when in the deployed configuration. The probe further comprises a tube arranged to house a distal portion of the feeding cable, and the deformable member surrounds at least part of the tube, and the tube is formed from an elastic material.

Abstract: A microwave ablation probe (100). The microwave ablation probe (100) comprises: an applicator (102) arranged to apply microwave radiation to heat surrounding tissue: a feed cable (104) arranged to supply electromagnetic energy to the applicator (102): a tubular shaft (105) arranged to house at least part of the length of the feed cable (104): a coolant flow path (106, 108) via which coolant is able to flow, the coolant flow path being located within a space between the tubular shaft (105) and the feed cable (102); and a choke (112) arranged to reduce power reflected from the applicator (102) along the feed cable (104). The choke comprises one or more bridging structures (114a. 114b. 14c) each provided on a component of the tubular shaft of the feed cable, the one or more bridging structures being arranged to extend across the space between the tubular shaft (105) and the feed cable (104) and form an electrical connection therebetween. The one or more bridging structures (114a. 114b.

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.

Abstract: A system for delivery of aerosol therapy includes a housing defining a chamber. The housing has a base, a top and a main body extending therebetween. An ambient air inlet is adjacent the base and is normally closed by an inlet valve. The housing has a patient port. Exhaled air is exhausted through valves in a mouthpiece or a face mask to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.

Abstract: A microwave ablation probe is disclosed. The microwave ablation probe includes an applicator arranged to apply microwave radiation to heat surrounding tissue; a feeding cable arranged to supply electromagnetic energy to the applicator; an antenna portion of an inner conductor of the feeding cable, the antenna portion extending distally from a distal end of an outer conductor of the feeding cable; and an overlapping portion of the inner conductor at least partly overlapping the antenna portion along the length of the antenna portion of the inner conductor and extending along a helical path around the antenna portion of the inner conductor.

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.

Abstract: A microwave ablation probe (200; 300; 400), comprising: an applicator (202; 302; 402) arranged to apply microwave radiation to heat surrounding tissue; a feeding cable (204; 304; 404) arranged to supply electromagnetic energy to the applicator; a coolant flow path (206) via which coolant is able to flow; and a choke arranged to reduce power reflected from the applicator (202; 302; 402) along the feeding cable (204; 304; 404). The choke comprises a choke member (208; 209; 308; 408) cooled by coolant flowing in the coolant flow path (206). The choke member (208; 209; 308; 408) extends between two points spaced apart in a direction having at least a component parallel to a longitudinal axis of the feeding cable. The choke member (208; 209; 308; 408) comprises one or more turns extending around the longitudinal axis of the feeding cable. The choke member may be a spiral member (208; 308; 408).

Abstract: A biopsy device (100), comprising: a cannula (102) comprising an elongate cannula body (106) extending between a cannula distal end (108) and a cannula proximal end (110) to define a lumen (112), wherein the cannula comprises a cutting portion at the cannula distal end (108); a stylet (104) comprising an elongate body (116) having a stylet distal end (118) and a stylet proximal end (120), the stylet (104) being slidably disposed within the lumen (112), wherein the stylet (104) comprises a tissue sampling portion (122); and an alignment means (126) arranged to maintain a preferred alignment between the stylet (104) and the cannula (102), wherein the alignment means (126) is arranged to align one or more of: i) relative rotation between the stylet distal end and the cannula distal end; ii) relative flexing between the stylet distal end and the cannula distal end; and iii) relative axial translation between the stylet distal end and the cannula distal end.

Abstract: A device (1, 20, 100, 200) to treat vaginal atrophy comprising a treatment module (2, 21, 101, 201) configured for insertion into the vagina and having a microtrauma module. The micro trauma module is configured to deliver negative pressure mechanical microtrauma therapy to a wall of the vagina when inserted. The microtrauma module comprises a plurality of apertures (6, 106, 206) in fluidic connection with a vacuum pump, the device being arranged to generate a negative pressure at the apertures (6, 106).

Abstract: An ablation probe (100; 200) comprising: an applicator (102; 202) arranged to apply radiation to heat surrounding tissue; a feeding cable (104; 204) arranged to supply electromagnetic energy to the applicator; a coolant flow path (106, 108) forming a coolant supply circuit; a tubular member (112; 212) housing at least part of the feeding cable (104; 204), wherein a part of the coolant flow path is defined by a space between the feeding cable and the tubular member; and a coupling body (114). The coupling body comprises: a cavity (116) in which the applicator (102; 204) is at least partly encapsulated; a coupling interface (118) at which the coupling body (114) is coupled to the tubular member; and a pointed distal tip (H4a) adapted for piercing tissue.

Abstract: An ablation probe (100; 200) suitable for insertion through the working channel of an intraluminal delivery device comprises an applicator (102; 202) arranged to apply radiation to heat surrounding tissue. The probe also comprises a feeding cable (104; 204) arranged to supply electromagnetic energy to the applicator (102; 202). The probe further comprises a first coolant flow path (106). There is also a deformable member (110; 210) arranged to move between an insertion configuration in which insertion of the probe is facilitated and a deployed configuration. A second coolant path (108), via which coolant is able to flow, is provided by the deformable member (110; 210) when in the deployed configuration. The probe further comprises a tube arranged to house a distal portion of the feeding cable, and the deformable member surrounds at least part of the tube, and the tube is formed from an elastic material.

Abstract: An ablation probe (1; 100; 200), comprising: an applicator (2; 102; 202) arranged to apply radiation to heat surrounding tissue; a feeding cable (4; 104; 204) arranged to supply electromagnetic energy to the applicator. The feeding cable comprises a distal portion (2a, 202a) and a proximal portion (2b; 202b). The distal portion of the feeding cable has a distal cross sectional size and the proximal portion of the feeding cable has a proximal cross sectional size, wherein the distal cross sectional size is less that the proximal cross sectional size. The ablation probe further comprises a connector (24; 224) arranged to mechanically and electrically couple the distal portion (2a, 202a) of the feeding cable (2; 202) to the proximal portion (2b; 202b) of the feeding cable (2; 202).

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.

Abstract: A microwave ablation probe (200; 300; 400), comprising: an applicator (202; 302; 402) arranged to apply microwave radiation to heat surrounding tissue; a feeding cable (204; 304; 404) arranged to supply electromagnetic energy to the applicator; a coolant flow path (206) via which coolant is able to flow; and a choke arranged to reduce power reflected from the applicator (202; 302; 402) along the feeding cable (204; 304; 404). The choke comprises a choke member (208; 209; 308; 408) cooled by coolant flowing in the coolant flow path (206). The choke member (208; 209; 308; 408) extends between two points spaced apart in a direction having at least a component parallel to a longitudinal axis of the feeding cable. The choke member (208; 209; 308; 408) comprises one or more turns extending around the longitudinal axis of the feeding cable. The choke member may be a spiral member (208; 308; 408).

Abstract: A biopsy device (100), comprising: a cannula (102) comprising an elongate cannula body (106) extending between a cannula distal end (108) and a cannula proximal end (110) to define a lumen (112), wherein the cannula comprises a cutting portion at the cannula distal end (108); a stylet (104) comprising an elongate body (116) having a stylet distal end (118) and a stylet proximal end (120), the stylet (104) being slidably disposed within the lumen (112), wherein the stylet (104) comprises a tissue sampling portion (122); and an alignment means (126) arranged to maintain a preferred alignment between the stylet (104) and the cannula (102), wherein the alignment means (126) is arranged to align one or more of: i) relative rotation between the stylet distal end and the cannula distal end; ii) relative flexing between the stylet distal end and the cannula distal end; and iii) relative axial translation between the stylet distal end and the cannula distal end.

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port.