Abstract: The present invention relates to novel, selective, radiolabelled compound having monoacylglycerol lipase (MGL) affinity which are useful for imaging and quantifying MGL receptor expression, distribution and enzyme occupancy in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.

Abstract: A novel substrate-bound DNAzyme complex is provided comprising a DNAzyme bound to a nucleic acid-based substrate. The DNAzyme comprises a pair of binding arms which hybridize to binding regions on the substrate, and a catalytic domain between the binding arms. The nucleic acid-based substrate comprises a phosphorothioate-modified ribonucleotide cleavage site between the binding regions of the substrate. The catalytic domain of the DNAzyme catalyzes heavy metal-dependent cleavage of the substrate cleavage site. The DNAzyme complex is useful in a method of heavy metal sensing. A novel cadmium-selective DNAzyme is also described for cadmium sensing.

Abstract: A novel substrate-bound DNAzyme complex is provided comprising a DNAzyme bound to a nucleic acid-based substrate. The DNAzyme comprises a pair of binding arms which hybridize to binding regions on the substrate, and a catalytic domain between the binding arms. The nucleic acid-based substrate comprises a phosphorothioate-modified ribonucleotide cleavage site between the binding regions of the substrate. The catalytic domain of the DNAzyme catalyzes heavy metal-dependent cleavage of the substrate cleavage site. The DNAzyme complex is useful in a method of heavy metal sensing. A novel cadmium-selective DNAzyme is also described for cadmium sensing.

Abstract: In one embodiment, the methods and apparatuses detect a message; detect a message term within the message; search for a match between the message term and a stored term; and display a description based on the match wherein the description is utilized for describing the message term and the description corresponds with the stored term.

Abstract: In one embodiment, an original search input entered by a user is detected. An excluded term is deleted from the original search input to create a modified search input. The modified search input is matched against a plurality of stored terms. In response to there being a match between the modified search input and one or more of the plurality of stored terms, a suggestion of a search term to replace the original search input is displayed, based on the match between the modified search input and one or more stored terms. In response to there not being a match between the modified search input and one or more of the plurality of stored terms, a suggestion of a search term to replace the original search input is displayed, based on a match between the original search input and one or more of the plurality of stored terms.

Abstract: In one embodiment, an original search input entered is detected. A plurality of stored terms in a record are detected. The original search input is modified to remove an excluded term from the search input to form a modified search input. The modified search input is matched against the plurality of stored terms to form a first result that includes a number of the stored terms. The number of the stored terms in the first result is compared to a threshold value. In response to the number of the stored terms in the first result satisfying the threshold value, the stored terms of the first result are displayed. Otherwise, the original search input is matched against the plurality of stored terms to form a second result that includes a number of the stored terms, and the stored terms of the second result are displayed.

Abstract: In one embodiment, an original search input entered is detected. A plurality of stored terms in a record are detected. The original search input is modified to remove an excluded term from the search input to form a modified search input. The modified search input is matched against the plurality of stored terms to form a first result that includes a number of the stored terms. The number of the stored terms in the first result is compared to a threshold value. In response to the number of the stored terms in the first result satisfying the threshold value, the stored terms of the first result are displayed. Otherwise, the original search input is matched against the plurality of stored terms to form a second result that includes a number of the stored terms, and the stored terms of the second result are displayed.

Abstract: In one embodiment, the methods and apparatuses detect an original search input; detect an excluded term within the original search input; form a modified search input wherein the modified search input includes the original search input without the excluded term; match a plurality of stored terms against the modified search input and forming a modified matched result; and selectively display the modified matched result based on a number of terms within the modified matched result.

Abstract: In one embodiment, an original search input entered by a user is detected. An excluded term is deleted from the original search input to create a modified search input. The modified search input is matched against a plurality of stored terms. In response to there being a match between the modified search input and one or more of the plurality of stored terms, a suggestion of a search term to replace the original search input is displayed, based on the match between the modified search input and one or more stored terms. In response to there not being a match between the modified search input and one or more of the plurality of stored terms, a suggestion of a search term to replace the original search input is displayed, based on a match between the original search input and one or more of the plurality of stored terms.

Abstract: In one embodiment, the methods and apparatuses detect an original search input; detect an excluded term within the original search input; form a modified search input wherein the modified search input includes the original search input without the excluded term; match a plurality of stored terms against the modified search input and forming a modified matched result; and display a suggestion based on the modified matched result.

Abstract: In one embodiment, the methods and apparatuses detect a message; detect an original search term; search for a match between the original search term and a term within the message; and selectively modify the original search term based on a number of matches.

Abstract: In one embodiment, the methods and apparatuses detect a message; detect a message term within the message; search for a match between the message term and a stored term; and display a description based on the match wherein the description is utilized for describing the message term and the description corresponds with the stored term.

Abstract: In one embodiment, the methods and apparatuses detect an original search input; detect an excluded term within the original search input; form a modified search input wherein the modified search input includes the original search input without the excluded term; match a plurality of stored terms against the modified search input and forming a modified matched result; and selectively display the modified matched result based on a number of terms within the modified matched result.

Abstract: In one embodiment, the methods and apparatuses detect an original search input; detect an excluded term within the original search input; form a modified search input wherein the modified search input includes the original search input without the excluded term; match a plurality of stored terms against the modified search input and forming a modified matched result; and display a suggestion based on the modified matched result.

Abstract: In one embodiment, the methods and apparatuses detect a query; detect a plurality of available participants; search a plurality of electronic mail messages associated with the plurality of available participants based on the query; and identify a qualified participant from the plurality of available participants based on searching the plurality of electronic mail messages.

Abstract: A method of generating a protected standard delay format (SDF) file is disclosed. The interconnect delay descriptions of a SDF file are backwardly or forwardly integrated into the related cell delay descriptions according to their interconnection type to generate the protected SDF file. The total delay value of each signal path is the same as original, so that the simulation result generated by a simulator is not affected.

Abstract: A configuration of conductive bumps on a flip chip and a redistribution layer is disclosed. The configuration comprise: a plurality of power bumps and ground bumps disposed in hive-shaped arrangement on the core of a flip chip; a plurality of power lines slanted by 60-degree angle, relative to a horizontal line, for connecting power bumps; and a plurality of ground lines slanted by 60-degree angle, relative to a horizontal line, for connecting ground bumps. The conductive bumps of the second embodiment are disposed in a checkerboard arrangement. The conductive bumps of the third embodiment are disposed in a staggered arrangement, and the power bumps and the ground bumps are respectively connected by power lines and ground lines, which are slanted in 45-degree angle, relative to a horizontal line. The power lines and the ground lines are in the redistribution layer.

Abstract: A bump arrangement of a flip-chip is disclosed. The bump arrangement comprises: a conductive bumps array formed at a core region of the flip-chip, a first ring of conductive bumps surrounding the conductive bumps array, a second ring surrounding the first ring, a third ring surrounding the second ring, and a fourth ring surrounding the third ring. In the four rings of bumps, the bumps of the third ring and the fourth ring are staggered each other and most of them are provided for I/O signal terminal so as to reduce the length conductive traces for I/O signal connection. The bumps in the first and the second ring are provided for power connection or ground connection. The first ring, the second ring, the third ring, the fourth ring and the bump at the core region are connected to conductive traces of an interconnection layer through a redistribution layer. The redistribution layer is located in between a passivation layer and the interconnection layer.

Abstract: A configuration of conductive bumps on a flip chip and a redistribution layer is disclosed. The configuration comprise: a plurality of power bumps and ground bumps disposed in hive-shaped arrangement on the core of a flip chip; a plurality of power lines slanted by 60-degree angle, relative to a horizontal line, for connecting power bumps; and a plurality of ground lines slanted by 60-degree angle, relative to a horizontal line, for connecting ground bumps. The conductive bumps of the second embodiment are disposed in a checkerboard arrangement. The conductive bumps of the third embodiment are disposed in a staggered arrangement, and the power bumps and the ground bumps are respectively connected by power lines and ground lines, which are slanted in 45-degree angle, relative to a horizontal line. The power lines and the ground lines are in the redistribution layer.

Abstract: A bump arrangement of a flip-chip is disclosed. The bump arrangement comprises: a conductive bumps array formed at a core region of the flip-chip, a first ring of conductive bumps surrounding the conductive bumps array, a second ring surrounding the first ring, a third ring surrounding the second ring, and a fourth ring surrounding the third ring. In the four rings of bumps, the bumps of the third ring and the fourth ring are staggered each other and most of them are provided for I/O signal terminal so as to reduce the length conductive traces for I/O signal connection. The bumps in the first and the second ring are provided for power connection or ground connection. The first ring, the second ring, the third ring, the fourth ring and the bump at the core region are connected to conductive traces of an interconnection layer through a redistribution layer. The redistribution layer is located in between a passivation layer and the interconnection layer.