Abstract: A hybrid graft and method for implantation in a blood vessel of a patient is described. The hybrid graft may include a graft portion having proximal and distal ends and an expandable mesh secured to the distal end of the graft portion. The expandable mesh is configured to transition from an insertion to a deployed diameter. The hybrid graft may also include a tubular sleeve having a lumen configured to receive a part of the graft portion and the expandable mesh and a suture cuff positioned adjacent the expandable mesh. During deployment, the distal end of the hybrid graft is inserted through an opening in the blood vessel wall or an end of the vascular graft and expanded from the insertion to the deployed diameter to secure the hybrid graft within the blood vessel or vascular graft. The suture cuff is sutured to the blood vessel or vascular graft.

Abstract: A vascular graft may be configured to transition from an insertion state to a deployed state. The graft comprising a proximal end having an expandable mesh, a distal end having an expandable mesh, and at least one suture cuff positioned between the proximal and distal ends, wherein each suture cuff comprises additional material relative to the proximal and distal ends that is configured to form when the vascular graft transitions from the insertion state to the deployed state.

Abstract: A vascular graft deployment tool may include a grip, an elongated mandrel positioned distal of the grip, a vascular graft, at least part of which is disposed coaxially about the mandrel, a sheath configured to be withdrawn proximally that constrains the vascular graft against the mandrel in an insertion diameter and an actuator that is moveable relative to the grip and engages the sheath assembly. A first operation of the actuator causing withdrawal of the sheath to free at least a distal portion of the vascular graft and a repeated operation of the actuator causing further withdrawal of the sheath to free a proximal portion of the vascular graft.

Abstract: Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A retrieval sheath having an elongated shaft member with at least one region of modified flexibility that is configured compress the implant to a reduced profile for removal from the patient's body.

Abstract: A vascular graft deployment tool may include a grip, an elongated mandrel positioned distal of the grip, a vascular graft, at least part of which is disposed coaxially about the mandrel, a sheath assembly including a distal sheath portion and a proximal sheath potion, wherein the distal sheath portion and the proximal sheath portion are configured to constrain the vascular graft against the mandrel in an insertion diameter and a actuator that is moveable relative to the grip and engages the sheath assembly, wherein operation of the actuator causes at least one of the distal sheath portion and the proximal sheath portion to separate longitudinally to free at least a portion of the vascular graft. Further, a vascular graft is expandable from an insertion state to a deployed state and at least two suture cuffs are located between opposed ends of the vascular graft.

Abstract: A locking irrigation valve with is disclosed that features a valve body having a lumen, an irrigation port in fluid communication with the lumen, a connector configured couple to a cystoscope so that the lumen is aligned with a working channel of the cystoscope, a collet having a compressible inner bore and a lock configured to engage the collet and compress the inner bore.

Abstract: The invention is devices and methods to treat benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms infections (LUTS). The devices are intra-urethral implants placed in a patient in need thereof by minimally invasive procedures, preferably under local anesthesia in an office environment. The devices are sized and designed for atraumatic insertion and expansion within the urethra to engage and retract enlarged prostatic tissue proximate to the urethra that is leading to adverse symptoms associated with BPH. The methods include steps to deploy the implant devices of the invention using a delivery system of the invention and at target prostatic tissue that is visualized during the procedure and yields a reduction in the symptoms of BPH.

Abstract: An self-actuating grasping device and corresponding method of using the grasping device for retrieving a foreign object from a location in a patient's body. The grasping device has a handle with a self-actuating mechanism, an actuator on the handle coupled to an actuator wire, an elongated shaft member extending distally from the handle with the actuation wire coaxially disposed therein and opposing jaws at a distal end of the elongated shaft member that are coupled to the actuation wire and pivot between open and closed configurations. The self-actuating mechanism has a bias that imparts a closing force to the opposing jaws through the actuation wire. Actuation of the actuator is configured to impart an opening force to the opposing jaws through the actuation wire.

Abstract: Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A retrieval sheath having an elongated shaft member with at least one region of modified flexibility that is configured compress the implant to a reduced profile for removal from the patient's body.

Abstract: Devices and systems are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). An implant is maintained in a constrained configuration within a distal portion of an elongated sheath so that is may be deployed by driving the implant with a pusher coaxially disposed within the sheath. An implant engaging element helps maintain control of the implant during deployment.

Abstract: A vascular graft may be configured to transition from an insertion state to a deployed state. The graft comprising a proximal end having an expandable mesh, a distal end having an expandable mesh, and at least one suture cuff positioned between the proximal and distal ends, wherein each suture cuff comprises additional material relative to the proximal and distal ends that is configured to form when the vascular graft transitions from the insertion state to the deployed state.

Abstract: A vascular graft deployment tool may include a grip, an elongated mandrel positioned distal of the grip, a vascular graft, at least part of which is disposed coaxially about the mandrel, a sheath configured to be withdrawn proximally that constrains the vascular graft against the mandrel in an insertion diameter and an actuator that is moveable relative to the grip and engages the sheath assembly. A first operation of the actuator causing withdrawal of the sheath to free at least a distal portion of the vascular graft and a repeated operation of the actuator causing further withdrawal of the sheath to free a proximal portion of the vascular graft.

Abstract: A vascular graft deployment tool may include a grip, an elongated mandrel positioned distal of the grip, a vascular graft, at least part of which is disposed coaxially about the mandrel, a sheath assembly including a distal sheath portion and a proximal sheath potion, wherein the distal sheath portion and the proximal sheath portion are configured to constrain the vascular graft against the mandrel in an insertion diameter and a actuator that is moveable relative to the grip and engages the sheath assembly, wherein operation of the actuator causes at least one of the distal sheath portion and the proximal sheath portion to separate longitudinally to free at least a portion of the vascular graft. Further, a vascular graft is expandable from an insertion state to a deployed state and at least two suture cuffs are located between opposed ends of the vascular graft.

Abstract: An endovascular guide catheter includes a guide tube and a handle. The flexible guide tube has a distal end portion configured to deflect via actuation of a pull wire. The handle is coupled to the guide tube and comprises a steering assembly configured to actuate the pull wire to deflect the distal end portion of the guide tube. The steering assembly can comprise a stationary rack, a gear, a reel, and a slider. The gear engages the rack and the reel is coupled to and configured to rotate with the gear. The pull wire is coupled to the reel such that rotation of the reel causes the pull wire to wind or unwind around the reel. The slider is adapted for translation relative to the rack. Translation of the slider translates the reel relative to the rack and rotation of the gear along the rack rotates the reel.

Abstract: A hybrid graft and method for implantation in a blood vessel of a patient is described. The hybrid graft may include a graft portion having proximal and distal ends and an expandable mesh secured to the distal end of the graft portion. The expandable mesh is configured to transition from an insertion to a deployed diameter. The hybrid graft may also include a tubular sleeve having a lumen configured to receive a part of the graft portion and the expandable mesh and a suture cuff positioned adjacent the expandable mesh. During deployment, the distal end of the hybrid graft is inserted through an opening in the blood vessel wall or an end of the vascular graft and expanded from the insertion to the deployed diameter to secure the hybrid graft within the blood vessel or vascular graft. The suture cuff is sutured to the blood vessel or vascular graft.

Abstract: A method and deployment tool for implanting a graft in a blood vessel of a patient. The deployment tool may include a mandrel with a dilator tip at a distal end and an inner passage defined through the dilator tip. The tool may also include a graft having a first end and a second end, at least part of which is placed about the mandrel. A sheath may be wrapped about at least part of the graft so that the graft is compressed at least partially against the mandrel by the sheath to an insertion diameter. The graft may be implanted by advancing the deployment tool to insert the first end of the graft through an opening in a wall of the blood vessel, removing the sheath from the graft, and expanding at least the first end of the graft to secure the graft within the blood vessel.

Abstract: An assembly and method for implanting a graft in a blood vessel of a patient including a graft having proximal and distal ends, with an expandable mesh positioned adjacent one of the ends and a cover extending from the proximal to distal ends. The graft may have a proximal removable sheath disposed over a portion of the graft corresponding to the proximal end and a distal removable sheath disposed over a portion of the graft corresponding to the distal end. Each sheath may be configured to compress the graft to an insertion diameter relative to a deployed diameter. The graft may be deployed by inserting the distal end of the graft through an opening in a wall of the blood vessel, removing the distal sheath and expanding the distal end of the graft from the insertion diameter to the deployed diameter to secure the graft within the blood vessel.

Abstract: A graft and method for implantation of the graft in a blood vessel of a patient is described. The graft may have proximal and distal ends, with an expandable mesh positioned adjacent the distal end that is configured to transition from an insertion diameter relative to a deployed diameter. The graft may also include a cover configured to extend at least from the proximal end to the distal end and a suture cuff positioned adjacent the distal end. During deployment, the distal end of the graft may be inserted through an opening in a wall of the blood vessel or an end of the vascular graft. The distal end of the graft is expanded from the insertion diameter to the deployed diameter to secure the graft within the blood vessel or the vascular graft. The suture cuff of the graft is sutured to the blood vessel or the vascular graft.

Abstract: A containment structure for use with a workpiece vascular graft may include a sheath having two lateral edges; holes defined through the sheath in proximity to the lateral edges of the sheath, wherein longitudinally-adjacent holes are spaced longitudinally from one another; and a pull wire extending through the holes. A medical apparatus may include a vascular graft self-expandable from an insertion state to a deployed state; and a suture cuff located at one end of the vascular graft. A deployment tool may include a mandrel; a vascular graft placed about the mandrel, and a sheath wrapped about the vascular graft, wherein the sheath compresses the vascular graft to an insertion diameter. A hybrid graft may include a graft and a stent, where an end of the graft is affixed to an end of the stent.

Abstract: An endovascular guide catheter includes a guide tube and a handle. The flexible guide tube has a distal end portion configured to deflect via actuation of a pull wire. The handle is coupled to the guide tube and comprises a steering assembly configured to actuate the pull wire to deflect the distal end portion of the guide tube. The steering assembly can comprise a stationary rack, a gear, a reel, and a slider. The gear engages the rack and the reel is coupled to and configured to rotate with the gear. The pull wire is coupled to the reel such that rotation of the reel causes the pull wire to wind or unwind around the reel. The slider is adapted for translation relative to the rack. Translation of the slider translates the reel relative to the rack and rotation of the gear along the rack rotates the reel.