Patents by Inventor Jimmy Rotolo

Jimmy Rotolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CERAMIDE ANTIBODIES
    Publication number: 20230416409
    Abstract: Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
    Type: Application
    Filed: August 15, 2022
    Publication date: December 28, 2023
    Inventors: Jimmy ROTOLO, Richard KOLESNICK
  • BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN
    Publication number: 20230277617
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphylococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Application
    Filed: November 11, 2022
    Publication date: September 7, 2023
    Inventors: Raymond SCHUCH, Robert C. NOWINSKI, Michael WITTEKIND, Babar KHAN, Jimmy ROTOLO
  • Biofilm prevention, disruption and treatment with bacteriophage lysin
    Patent number: 11524046
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: December 13, 2022
    Assignee: CONTRAFECT CORPORATION
    Inventors: Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Babar Khan, Jimmy Rotolo
  • Anti-ceramide antibodies
    Patent number: 11447572
    Abstract: Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: September 20, 2022
    Assignees: MEMORIAL SLOAN KETTERING CANCER CENTER, CERAMIDE THERAPEUTICS
    Inventors: Jimmy Rotolo, Richard Kolesnick
  • ANTI-CERAMIDE ANTIBODIES
    Publication number: 20190389970
    Abstract: Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
    Type: Application
    Filed: September 11, 2019
    Publication date: December 26, 2019
    Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, CERAMIDE THERAPEUTICS
    Inventors: Jimmy ROTOLO, Richard KOLESNICK
  • BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN
    Publication number: 20190387745
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Application
    Filed: April 22, 2019
    Publication date: December 26, 2019
    Inventors: Raymond SCHUCH, Robert C. NOWINSKI, Michael WITTEKIND, Babar KHAN, Jimmy ROTOLO
  • Anti-ceramide antibodies
    Patent number: 10450385
    Abstract: Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 22, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, Ceramide Therapeutics
    Inventors: Jimmy Rotolo, Richard Kolesnick
  • ANTI-CERAMIDE ANTIBODIES
    Publication number: 20170335014
    Abstract: Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
    Type: Application
    Filed: August 7, 2015
    Publication date: November 23, 2017
    Inventors: Jimmy ROTOLO, Richard KOLESNICK
  • BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN
    Publication number: 20170127683
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphylococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Application
    Filed: October 14, 2016
    Publication date: May 11, 2017
    Inventors: Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Babar Khan, Jimmy Rotolo
  • Biofilm prevention, disruption and treatment with bacteriophage lysin
    Patent number: 9499594
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: November 22, 2016
    Assignee: Contrafect Corporation
    Inventors: Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Babar Khan, Jimmy Rotolo
  • BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN
    Publication number: 20150111813
    Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
    Type: Application
    Filed: May 9, 2013
    Publication date: April 23, 2015
    Inventors: Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Babar Khan, Jimmy Rotolo