Abstract: A system and method for personalization, and replication of diagnosis and treatment processes, with instruction, observations, and diagnosis is disclosed. Patient interaction steps such as prompting diagnosis inquiries, requesting diagnosis responses, recording the responses, revising diagnosis inquiries and generation of diagnosis report text, which is also revisable, draw on information from a global database to guide a medical professional through diagnosis. Revisions to diagnosis inquiries and diagnosis report text are saved in personalized databases and replicated for use by other medical professionals. The system is utilized within a particular practice site, and the practice site is in communication with a network of additional practice sites, central processor, and central databases. Revised patient interactions which prove more successful are replicated to for use by other medical professionals within the same practice site and at other practice sites.